Creation of polymeric contrast agent systems possessing multiple imaging modalities
| Project/Area Number |
22300170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRAISHI Kouichi 東京慈恵会医科大学, 医学部, 講師 (40426284)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 薬物送達システム / 画像診断 / 合成高分子 / 造影剤 / モダリティー / 高分子ミセル / エマルション / DDS / MRI / 超音波画像診断 |
|---|
| Research Abstract |
In this study, we have designed polymer-based contrast agent carrier systems that can be applied in multiple imaging modalities;MRI, PET, SPECT, and ultrasound. Using a polymeric micelle MRI contrast agent, we succeeded in targeting to murine solid tumors and obtained substantial enhancementsof image contrast at the tumor sites. Additionally, this polymeric micelle contrast agent did not show any ABC phenomenon. Since the ABC phenomenon is seriously detrimental to multiple doses of contrast agents, this fact indicates a very high value of the polymeric micelle contrast agent in clinical use.
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Report
(4 results)
Research Products
(100 results)
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[Journal Article] Hydrophobic Molecules Infiltrating into the PEG Domain of the Core/Shell Interface of a Polymeric Micelle: Evidence Obtained with Anomalous Small-Angle X-ray Scattering2013
Author(s)
Sanada, Y.; Akiba, I.; Sakurai, K. Shiraishi, K.; Yokoyama, M.;Mylonas, E.; Ohta, N.; Yagi, N.; Shinohara, Y.; Amemiya, Y
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Journal Title
Journal of the American Chemical Society
Volume: 135(7)
Pages: 2574-82
Related Report
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[Journal Article] Hydrophobic Molecules Infiltrating into the PEG Domain of the Core/Shell Interface of a Polymeric Micelle: Evidence Obtained with Anomalous Small-Angle X-ray Scattering.2013
Author(s)
Sanada, Yusuke; Akiba, Isamu; Sakurai, Kazuo; Shiraishi, Kouichi; Yokoyama, Masayuki; Mylonas, Efstratios; Ohta, Noboru; Yagi, Naoto; Shinohara, Yuya; Amemiya, Yoshiyuki
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Journal Title
Journal of the American Chemical Society
Volume: 135
Issue: 7
Pages: 2574-82
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy of Cancers2013
Author(s)
Hayato Koganei, Manabu Ueno, Shoji Tachikawa, Lisa Tasaki, Hyun Seung Ban, Minoru Suzuki, Kouichi Shiraishi, Kumi Kawano, Masayuki Yokoyama, Yoshie Maitani, Koji Ono, and Hiroyuki Nakamura
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Journal Title
Bioconjugate Chemistry
Volume: 24
Issue: 1
Pages: 124-132
DOI
Related Report
Peer Reviewed
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[Journal Article] A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors2011
Author(s)
K. Shiraishi, R. Endoh, H. Furuhata, M. Nishihara, R. Suzuki, K. Maruyama, Y. Oda, J. Jo, Y. Tabata, J. Yamamoto, M. Yokoyama
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Journal Title
International J. of Pharmaceutics
Volume: 421
Pages: 379-87
Related Report
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[Journal Article] Encapsulation of a Hydrophobic Drug into a Polymer-Micelle Core Explored with Synchrotron SAXS.2010
Author(s)
Isamu Akiba, Naotaka Terada, Satoshi Hashida, Kazuo Sakurai, Taku Sato, Kouichi Shiraishi, Masayoshi, Yokoyama, Hiroyasu Masunaga, Hiroki Ogawa, Naoto Yagi
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Journal Title
Langmuir
Volume: 26
Pages: 7544-7551
Related Report
Peer Reviewed
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[Journal Article] Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts.2010
Author(s)
Michiko Yokosawa, Yukihiko Sonoda, Shin-ichiro Sugiyama, Ryuta Saito, Yoji Yamashita, Masamichi Nishihara, Taku Satoh, Toshihiro Kumabe, Masayuki Yokoyama, Teiji Tominaga
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Journal Title
Tohoku J.Exp.Med.
Volume: 221
Pages: 257-64
NAID
Related Report
Peer Reviewed
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