| Project/Area Number |
22300243
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
|---|
Principal Investigator |
KIM Hunkyung 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (20282345)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Takao 国立長寿医療センター, 研究所, 所長 (30154545)
YOSHIDA Hideyo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (00242735)
SHIMADA Hiroyuki 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (00370974)
SAITO Kyoko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都建国長寿医療センター研究所, 研究員 (20507389)
FURUNA Taketo 札幌医科大学, 保健医療学部, 準教授 (20238687)
OBUCHI Shuichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50265740)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
|---|
| Keywords | 運動処方と運動療法 / サルコペニア / サルコぺニア / 包括的介入 / 追跡調査 / 後期高齢者 / 転倒 / 運動 / 必須アミノ酸 / プログラムの長期効果 / 老年症候群 / カテキン |
|---|
| Research Abstract |
The prevalence of sarcopenia was 22.1% in community-dwelling elderly women. The comparison of several variables between the sarcopenic and normal group shows that sarcopenic women had significantly lower calf girth, bone mineral density, BMI, and muscle mass, and were older. Additionally, sarcopenic women had a higher history of osteoporosis, falls, and fractures rates compared with normal subjects. To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass and strength in community-dwelling elderly sarcopenic women. One hundred fifty-five women aged 75 and older were defined as sarcopenic and randomly assigned to one of four groups : exercise and amino acid supplementation (exercise + AAS; n = 38), exercise (n = 39), amino acid supplementation (AAS; n = 39), or health education (HE; n = 39). The exercise group attended a 60-minute comprehensive training program twice a week, and the AAS group ingested 3 g of a leucine-rich essential amino acid mi
… More
xture twice a day for 3 months. Body composition was determined using bioelectrical impedance analysis. Data from interviews and functional fitness parameters such as muscle strength and walking ability were collected at baseline and after the 3-month intervention. A significant group × time interaction was seen in leg muscle mass (P = .007), usual walking speed (P = .007), and knee extension strength (P = .017). The within-group analysis showed that walking speed significantly increased in all three intervention groups, leg muscle mass in the exercise + AAS and exercise groups, and knee extension strength only in the exercise + AAS group (9.3% increase, P = .010). The odds ratio for leg muscle mass and knee extension strength improvement was more than four times as great in the exercise + AAS group (odds ratio = 4.89, 95% confidence interval = 1.89-11.27) as in the HE group. The data suggest that exercise and AAS together may be effective in enhancing not only muscle strength, but also combined variables of muscle mass and walking speed and of muscle mass and strength in sarcopenic women. Less
|
