Development of multi-lateral cancer gene therapy by enhancing anti-tumor activity of inactivated Sendai virus particle
| Project/Area Number |
22300339
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | Osaka University |
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Principal Investigator |
KANEDA Yasufumi 大阪大学, 大学院・医学系研究科, 教授 (10177537)
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| Co-Investigator(Kenkyū-buntansha) |
TANEMURA Atsushi 大阪大学, 大学院・医学系研究科, 助教 (50457016)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | HVJ / 癌 / 抗腫瘍免疫 / アポトーシス / 遺伝子解析 / 遺伝子治療 / 核酸医薬 |
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| Research Abstract |
We have reported that UV-inactivated Sendai virus particles (hemagglutinating virus of Japan envelope; HVJ-E) have multiple anti-tumor activities. Clinical application of HVJ-E has been started to evaluate the safety and efficacy of the particle in cancer patients. To enhance the anti-tumor activities, we attempted to incorporate therapeutic molecules into HVJ-E. As a result, HVJ-E containing IL2 or IL-12 gene enhanced anti-tumor immunity. HVJ-E having IL-12 polypeptide on the surface was developed and was more effective for the treatment of melanoma than original HVJ-E alone. Rad51 siRNA incorporated into HVJ-E augmented the effect of cancer treatment when combined with anti-tumor reagent, dacarbazine.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Immunogene therapy using immunomodulating HVJ-E vector augments anti-tumor effects in murine malignant glioma.2011
Author(s)
Matsuda, M., Nimura, K., Shimbo, T., Hamasaki, T., Yamamoto, T., Matsumura, A. and Kaneda, Y
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Journal Title
J. Neuro-Oncology
Volume: 103
Pages: 19-31
Related Report
Peer Reviewed
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[Journal Article] Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus2011
Author(s)
Fujita, H., Tamai, K., Kawachi, M., Saga, K., Yamasaki, T., Kaneda Y.
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Journal Title
Archives of Virology
Volume: 156
Pages: 995-1005
Related Report
Peer Reviewed
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[Journal Article] Immunogene therapy using immunomodulating HVJ-E vector augments and-tumor effects in murine malignant glioma.2011
Author(s)
Matsuda, M., Nimura, K., Shimbo, T., Hamasaki, T., Yamamoto, T., Matsumura, A., Kaneda, Y.
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Journal Title
J.Neuro-Oncology
Volume: (In press)
Related Report
Peer Reviewed
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