Molecular mechanism to construct the DNA repair related higher order nuclear structures
| Project/Area Number |
22310036
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
TASHIRO Satoshi 広島大学, 原爆放射線医科学研究所, 教授 (20243610)
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| Co-Investigator(Kenkyū-buntansha) |
SUN Jiying 広島大学, 原爆放射線医科学研究所, 講師 (80397926)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 放射線被ばく / ゲノム損傷 / 細胞核構造 / RAD51 / 構造関連蛋白質 / 細胞核構造変換 |
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| Research Abstract |
Reorganization of higher order nuclear structures has been thought to play an important role in DNA repair after ionizing radiation. However, the precise mechanism of radiation-induced reorganization of nuclear architecture is still unclear. In this study, we studied the molecular mechanisms involved in the formation of radiation induced higher order nuclear structures. We found that Matrin3 (MATR3), a nuclear structure-related protein, is involved in the regulation of the intra-nuclear dynamics of DNA repair protein RAD51. We also found that MATR3 plays a role in the regulation of the recombinational repair activity. These findings suggest the involvement of nuclear architecture in the regulation of DNA repair after ionizing radiation.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] A Modified System for Analyzing Ionizing Radiation-Induced Chromosome Abnormalitie2012
Author(s)
Shi L, Fujioka K, Sun J, Kinomura A, Inaba T, Ikura T, Ohtaki M, Yoshida M, Kodama Y, Livingston GK, Kamiya K, Tashiro S
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Journal Title
Radiat Res
Volume: 177(5)
Pages: 533-538
Related Report
Peer Reviewed
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[Journal Article] Regulation of homologous recombination by RNF20-dependent H2B ubiquitination2011
Author(s)
Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira DV, Shimada M, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K
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Journal Title
Mol Cell
Volume: 41(5)
Pages: 515-28
NAID
Related Report
Peer Reviewed
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[Journal Article] ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot2010
Author(s)
Sun, J., Oma, Y., Harata, M., Kono, K., Shima, H., Kinomura, A., Ikura, T., Mizutani, S., Kanaarm, R., Tashiro, S
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Journal Title
PLoS One
Volume: 5
Issue: 10
Pages: e13554-e13554
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration2010
Author(s)
Tazaki T, Sasaki T, Uto K, Yamasaki N, Tashiro S, Sakai R, Tanaka M, Oda H, Honda Z, Honda H
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Journal Title
Hepatology
Volume: 52(3)
Pages: 1089-1099
Related Report
Peer Reviewed
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[Journal Article] Involvement of ribonucleotide reductase-M1 in 5-fluorouracil-induced DNA damage in esophageal cancer cell lines
Author(s)
Aoki Y, Sakogawa K, Hihara J, Emi M, Hmamai Y, Kono K, Shi L, Sun J, Kitao H, Ikura T, Niida H, Nakanishi M, Okada M, Tashiro S
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] A functional deficiency of TERA/VCP/p97 contributes to impaired DNA damage repair in multiple polyglutamine diseases
Author(s)
Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Sishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H.
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Peer Reviewed
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[Presentation] A new system for analyzing ionizing radiation-induced chromosome abnormalities2011
Author(s)
時 林, 藤岡来実, 孫 継英, 木野村愛子, 稲葉俊哉, 井倉 毅, 大瀧 慈, 吉田 光 明 , 児 玉 吉 明 , Gordon K. Livingston, 神谷研二, 田代 聡
Organizer
第34回日本分子生物学会
Place of Presentation
横浜
Year and Date
2011-12-13
Related Report
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[Presentation] A new system for analyzing ionizing radiation-induced chromosome abnormalities2011
Author(s)
時 林, 藤岡来実, 孫 継英, 木野村愛子, 稲葉俊哉, 井倉 毅, 大瀧 慈, 吉田光明,児玉吉明, Gordon K. Livingston,神谷研二, 田代 聡
Organizer
日本放射線影響学会 第54回大会
Place of Presentation
神戸
Year and Date
2011-11-17
Related Report
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[Presentation] A new system for analyzing ionizing radiation-induced chromosome abnormalities.2011
Author(s)
時 林, 藤岡来実, 孫 継英, 木野村愛子, 稲葉俊哉, 井倉 毅, 大瀧 慈, 吉田 光 明 , 児 玉 吉 明 , Gordon K. Livingston, 神谷研二, 田代 聡
Organizer
第84回日本生化学会大会
Place of Presentation
京都
Year and Date
2011-09-21
Related Report
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[Presentation] Comparison of telomere-centromere metaphase FISH with Giemsa staining in analysis of chromosome aberrations2010
Author(s)
時 林, 藤岡来実, 孫 継英, 木野村愛子, 稲葉俊哉, 山内基弘, 鈴木啓司, 山下俊一, 井倉 毅, 大瀧 慈, 吉田光明, 児玉喜明, Gordon K. Livingston, 神谷研二, 田代 聡
Organizer
第33回分子生物学会
Place of Presentation
神戸
Year and Date
2010-12-07
Related Report
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[Presentation] 広島原爆2世の親の被曝線量について2010
Author(s)
田代 聡, 鎌田七男, 木村昭郎, 三原圭一朗, 大瀧 慈, 星 正治, 川上秀史, 神谷研二
Organizer
日本放射線影響学会第53回大会
Place of Presentation
京都
Year and Date
2010-10-20
Related Report
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