Development of a biological dosimeter to detect the DNA damage induced by low dose radiation and carcinogenic risk evaluation
| Project/Area Number |
22310037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAMIYA Kenji 広島大学, 原爆放射線医科学研究所, 教授 (60116564)
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| Co-Investigator(Kenkyū-buntansha) |
SASATANI Megumi 広島大学, 原爆放射線医科学研究所, 助教 (80423052)
IIDUKA Daisuke 広島大学, 原爆放射線医科学研究所, 助教 (00455388)
MASUDA Yuji 名古屋大学, 環境医学研究所, 准教授 (30273866)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 低線量放射線 / REV1 / ゲノム障害 / ゲノム修復 / 損傷乗り越えDNA合成 / 放射線 / ポリメラーゼ / 突然変異 / 発がん / 損傷乗り換えDNA合成 |
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| Research Abstract |
It was explored the development of a biological dosimeter for low dose irradiation using our latest research data about mutagenesis. Rev1 Tg mice and Apc^Min/+mice, which are the model mice for human familial adenomatous polyposis coli, are used to generate Apc^Min/+; Rev1 Tg mice. The incidence of spontaneous and radiation-induced intestinal adenoma in Apc^Min/+; Rev1 Tg mice was significantly higher than that in Apc^Min/+; mice. Apc^Min/+; Rev1 Tg mouse is thought to be useful for the study of risk estimation of radiation-induced cancers.
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Report
(4 results)
Research Products
(96 results)
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[Journal Article] Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer2010
Author(s)
Huang QM, Tomida S, Masuda Y, Arima C, Cao K, Kasahara T, Osada H, Yatabe Y, Akashi T, Kamiya K, Takahashi T, Suzuki M
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Journal Title
Cancer Research
Volume: 70(21)
Pages: 8407-8411
Related Report
Peer Reviewed
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[Presentation] Function of RAD18 on radioresponse2013
Author(s)
Y. Xu, M. Sasatani, H. Kawai, K. Kamiya
Organizer
The 2nd International Symposium Phoenix Leader Education Program(Hiroshima Initiative) for Renaissance from Radiation Disaster -Suggestion for the Renaissance from Radiation Disaster-
Place of Presentation
Hiroshima
Year and Date
2013-02-10
Related Report
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[Presentation] 放射線発がんとゲノム不安定性2011
Author(s)
笹谷めぐみ, 徐 衍賓, 本田浩章, 濱崎幹也, 楠 洋一郎, 渡邊敦光, 増田雄司, 神谷研二
Organizer
日本放射線影響学会第54回大会
Place of Presentation
神戸市
Year and Date
2011-11-19
Related Report
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[Presentation] 被ばく医療とがん2011
Author(s)
神谷研二
Organizer
第49回日本癌治療学会学術集会
Place of Presentation
名古屋市(招待講演)
Year and Date
2011-10-27
Related Report
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[Presentation] 肺癌における POLD4 の関与2011
Author(s)
鈴木元, 冨田秀太, 有馬千夏, 増田雄司, 神谷研二, 長田啓隆, 谷田部恭, 高橋 隆
Organizer
第70回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
2011-10-03
Related Report
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[Presentation] 肺癌におけるPOLD4の関与2011
Author(s)
鈴木元, 冨田秀太, 有馬千夏, 増田雄司, 神谷研二, 長田啓隆, 谷田部恭, 高橋隆
Organizer
第70回日本癌学会学術総会
Place of Presentation
名古屋市
Year and Date
2011-10-03
Related Report
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