| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
It was explored the development of a biological dosimeter for low dose irradiation using our latest research data about mutagenesis. Rev1 Tg mice and Apc^Min/+mice, which are the model mice for human familial adenomatous polyposis coli, are used to generate Apc^Min/+; Rev1 Tg mice. The incidence of spontaneous and radiation-induced intestinal adenoma in Apc^Min/+; Rev1 Tg mice was significantly higher than that in Apc^Min/+; mice. Apc^Min/+; Rev1 Tg mouse is thought to be useful for the study of risk estimation of radiation-induced cancers.
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