| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Research Abstract |
Homologous recombination functions in DNA double strand break repair and meiotic recombination. Several proteins that are involved in the homologous recombination have been identified. However, missing recombination factors still exist in the homologous-recombination pathway. In this study, in humans, GEMIN2, EVL, and PSF, have been identified as novel homologous recombination proteins. Biochemical analyses with purified proteins revealed their functions in homologous recombination in vitro. In addition, we also found that FANCD2, an essential recombination protein, is robustly monoubiquitinated in the presence of DNA and FANCI.
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