Creation of small molecular resources with high function based on comprehensive natural products chemistry
| Project/Area Number |
22310133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAI A. Midori 千葉大学, 大学院・薬学研究院, 准教授 (40373261)
TOUME Kazufumi 千葉大学, 大学院・薬学研究院, 助教 (80563981)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 天然物化学 / 薬学 / 有機化学 / シグナル伝達 / 生理活性 / 植物 / 天然物 / スクリーニング |
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| Research Abstract |
In this study, we performed screening studies targeting TRAIL, Wnt, and Hedgehog signaling pathways which are related to mainly cancer diseases from the extracts of various natural resources as well as synthetic compounds library constructed in our group. As a result, we have isolated a number of bioactive natural products having effects on these signaling pathways and the molecular mechanisms of these active compounds were also investigated in this study.
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Report
(4 results)
Research Products
(84 results)
