| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Research Abstract |
Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using nanoparticles and nanostructured surfaces, as compared to matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using organic matrices, affords low-noise background (<500 Da). In this study, new atmospheric pressure(AP)-SALDI-MS was developed to achieve easily high-throughput analysis for low molecular weight compounds such as pollutants in environment, pharmaceutical products, and industry materials. Novel nanostructured surfaces and nanoparticle aggregates were designed to study effectiveness on AP-SALDI. The ionization mechanism of AP-SALDI is elucidated, compared with vacuum-SALDI. We could propose three new MS applications; 1) a complementary analytical methodology combining localized surface plasmon resonance (LSPR) sensing with SALDI-MS, 2) affinity SALDI-MS using magnetic nanoparticle, and 3) platinum vapor deposition SALD-MS imaging for small molecules.
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