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Expression mechanism of biocompatibility of polymer materials based on the state-change behavior of incorporated water molecules

Research Project

Project/Area Number 22350101
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Polymer/Textile materials
Research InstitutionUniversity of Toyama

Principal Investigator

KITANO Hiromi  富山大学, 理工学研究部(工学), 教授 (40115829)

Co-Investigator(Kenkyū-buntansha) GEMMEI Makoto  富山大学, 大学院・理工学研究部, 准教授 (70334711)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywords生体適合材料 / 水の構造 / 相転移 / 温度可変赤外分光法 / 低温結晶化水 / 生体適合性 / 吸着タンパク質 / 多重反射赤外分光法 / 高分子ブラシ / 両性高分子 / 和周波発生法 / O-H伸縮振動 / RAFT重合
Research Abstract

Using temperature-variable infrared spectroscopy, recrystallization phenomena (crystallization of water molecules during the heating process) observed for water molecules incorporated in blood-compatible polymer materials could be ascribed to state changes of monomeric or oligomeric water molecules and not to the transition of amorphous ice to crystal ice, which denied the presence of water molecules having a specific hydrogen-bonded network. Furthermore, the infrared measurements of water molecules incorporated in several kinds of polymer materials without blood compatibility indicated the presence of recrystallization phenomena, too. Comparing the glass transition temperature with the composition of elements in the polymers indicated that the recrystallization phenomena are strongly related to the mobility of polymer chains and the electrostatic interaction between water molecules and the polymers.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (52 results)

All 2014 2013 2012 2011 2010

All Journal Article (41 results) (of which Peer Reviewed: 18 results) Presentation (5 results) Book (5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Structure of water at zwitterionic copolymer film-liquid water interfaces as examined by the sum frequency generation method2014

    • Author(s)
      Kondo, T.; Nomura, K.; Gemmei-Ide, M.; Kitano, H.;Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 113 Pages: 361-367

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sum-frequency Generation Analyses on the Structure of Water at Amphoteric SAM-Liquid Water Interfaces2014

    • Author(s)
      Nomura, K.; Nakaji- Hirabayashi, T.; Gemmei-Ide, M.; Kitano, H.; Noguchi, H.; Uosaki, K.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sum-frequency Generation Analyses on the Structure of Water at Amphoteric SAM-Liquid Water Interfaces.2014

    • Author(s)
      Kouji Nomura, Tadashi Nakaji-Hirabayashi, Makoto Gemmei-Ide, Hiromi Kitano, Hidenori Noguchi, Kohei Uosaki
    • Journal Title

      Colloids Surfaces B: Biointerfaces

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of water at zwitterionic copolymer film-liquid water interfaces as examined by the sum frequency generation method.2014

    • Author(s)
      Kondo, T.; Nomura, K.; Gemmei-Ide, M.; Kitano, H.; Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B: Biointerfaces

      Volume: 113 Pages: 361-367

    • DOI

      10.1016/j.colsurfb.2013.08.051

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable microparticles for strictly regulating the release of neurotrophic factors2013

    • Author(s)
      Gujral, C.; Minagawa, Y.; Fujimoto, K.; Kitano, H.; Nakaji-Hirabayashi, T.
    • Journal Title

      J. Control. Release

      Volume: 168 Pages: 307-316

    • Related Report
      2013 Final Research Report
  • [Journal Article] Two-Step Recrystallization of Water in Concentrated Aqueous Solution of Poly(ethylene glycol)2013

    • Author(s)
      Gemmei-Ide, M.; Kasai, R.; Motonaga, T.; Kitano, H.
    • Journal Title

      J. Phys. Chem. B.

      Volume: 117 Pages: 2688-2694

    • NAID

      120006395335

    • Related Report
      2013 Final Research Report
  • [Journal Article] Self-association of zwitterionic polymer-lipid conjugates in water as examined by scattering measurements2013

    • Author(s)
      Murou, M.; Kitano, H.; Fujita, M.; Maeda, M.; Saruwatari, Y.
    • Journal Title

      J. Colloid Interface Sci.

      Volume: 390 Pages: 47-53

    • Related Report
      2013 Final Research Report
  • [Journal Article] Biodegradable microparticles for strictly regulating the release of neurotrophic factors.2013

    • Author(s)
      Gujral, C.; Minagawa, Y.; Fujimoto, K.; Kitano, H.; Nakaji-Hirabayashi, T.
    • Journal Title

      J. Control. Release

      Volume: 168 Issue: 3 Pages: 307-316

    • DOI

      10.1016/j.jconrel.2013.03.031

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-association of zwitterionic polymer-lipid conjugates in water as examined by scattering measurements.2013

    • Author(s)
      Murou, M.; Kitano, H.; Fujita, M.; Maeda, M.; Saruwatari, Y.
    • Journal Title

      J. Colloid Interface Sci.

      Volume: 390 Issue: 1 Pages: 47-53

    • DOI

      10.1016/j.jcis.2012.09.035

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-Step Recrystallization of Water in Concentrated Aqueous Solution of Poly(ethylene glycol).2013

    • Author(s)
      Gemmei-Ide, M.; Motonaga, T.; Kasai, R.; Kitano, H.
    • Journal Title

      J. Phys. Chem. B.

      Volume: 117 Issue: 7 Pages: 2188-2194

    • DOI

      10.1021/jp3102628

    • NAID

      120006395335

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymer brush with pendent glucosylurea groups constructed on a glass substrate2012

    • Author(s)
      Kitano, H.; Liu, T.; Tokuwa, K.; Li, L.; Iwanaga, S.; Nakamura, M.; Kanayama, N.; Ohno, K.; Saruwatari, Y.
    • Journal Title

      Eur. Polym. J.

      Volume: 48 Pages: 1875-1882

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structure of water in the vicinity of a zwitterionic polymer brush as examined by sum frequency generation method2012

    • Author(s)
      Kondo, T.; Nomura, K.; Murou, M.; Gemmei-Ide, M.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 100 Pages: 126-132

    • Related Report
      2013 Final Research Report
  • [Journal Article] Carboxymethylbetaine copolymer layer covalently fixed to a glass substrate2012

    • Author(s)
      Suzuki, H.; Li, L.; Nakaji, T.; Kitano, H.; Ohno, K.; Matsuoka. K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 94 Pages: 107-113

    • Related Report
      2013 Final Research Report
  • [Journal Article] Recrystallization of Water in Non-Water- Soluble (Meth)Acrylate Polymers is Not Rare and is Not Devitrification2012

    • Author(s)
      Gemmei-Ide, M.; Ohya, A.; Kitano, H.
    • Journal Title

      J. Phys. Chem. B.

      Volume: 116 Pages: 1850-1857

    • NAID

      120006395334

    • Related Report
      2013 Final Research Report
  • [Journal Article] Binding of β-amyloid to sulfated sugar residues in a polymer brush2012

    • Author(s)
      Kitano, H.; Saito, D.; Kamada, T.; Gemmei-Ide, M.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 93 Pages: 219-225

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] Sum frequency generation study on the structure of water in the vicinity of an amphoteric polymer brush2012

    • Author(s)
      Kondo, T.; Gemmei-Ide, M.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.
    • Journal Title

      Colloids Surfaces B. Biointerfaces

      Volume: 91 Pages: 215-218

    • Related Report
      2013 Final Research Report
  • [Journal Article] 固体高分子中の水の結晶化挙動と生体適合性の相関2012

    • Author(s)
      源明 誠, 北野博巳
    • Journal Title

      表面科学

      Volume: Vol.33 Pages: 15-20

    • NAID

      10030442907

    • Related Report
      2013 Final Research Report
  • [Journal Article] Polymer Brush with Pendent Glucosylurea Groups Constructed on a Glass Substrate by RAFT Polymerization2012

    • Author(s)
      Kitano H, Suzuki H, Kondo T, Sasaki K, Iwanaga S, Nakamura M, Ohno K, Saruwatari Y,
    • Journal Title

      European Polymer Journal

      Volume: 48(11) Issue: 11 Pages: 1875-1882

    • DOI

      10.1016/j.eurpolymj.2012.08.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of water in the vicinity of a zwitterionic polymer brush as examined by sum frequency generation method.2012

    • Author(s)
      Kondo, T.; Nomura, K.; Murou, M.; Gemmei-Ide, M.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B: Biointerfaces,

      Volume: 100 Pages: 126-132

    • DOI

      10.1016/j.colsurfb.2012.05.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carboxymethylbetaine copolymer layer covalently fixed to a glass substrate.2012

    • Author(s)
      Suzuki, H.; Li, L.; Nakaji-Hirabayashi, T.; Kitano, H.; Ohno, K.; Matsuoka. K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B: Biointerfaces

      Volume: 94 Pages: 107-113

    • DOI

      10.1016/j.colsurfb.2012.01.038

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding of β-amyloid to sulfated sugar residues in a polymer brush.2012

    • Author(s)
      Kitano, H.; Saito, D.; Kamada, T.; Gemmei-Ide, M.
    • Journal Title

      Colloids Surfaces B: Biointerfaces

      Volume: 93 Pages: 219-225

    • DOI

      10.1016/j.colsurfb.2012.01.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sum frequency generation study on the structure of water in the vicinity of an amphoteric polymer brush.2012

    • Author(s)
      Kondo, T.; Gemmei-Ide, T.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.
    • Journal Title

      Colloids Surfaces B. Biointerfaces

      Volume: 91 Pages: 215-218

    • DOI

      10.1016/j.colsurfb.2011.11.012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carboxymethylbetaine copolymer layer covalently flxed to a glass substrate2012

    • Author(s)
      Suzuki, H.; Li, L.; Nakaji, T.; Kitano, H.; Ohno, K.; Saruwatari, Y.; Matsuoka. K.
    • Journal Title

      Colloids Surfaces B ; Biointerfaces

      Volume: 94 Pages: 107-113

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sum frequency generation study on the structure of water in the vicinity of an amphoteric polymer brush2012

    • Author(s)
      Kondo, T.; Gemmei-Ide, M.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.
    • Journal Title

      Colloids Surfaces B.Biointerfaces

      Volume: 91 Pages: 215-218

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-biofouling properties of amphoteric polymer brush constructed on a glass substrate2011

    • Author(s)
      Kitano, H.; Kondo, T.; Iwanaga, S.; Nakamura, M.; Ohno, K.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 88 Pages: 455-462

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] Silica particles coated with zwitterionic polymer brush : Formation of colloidal crystals and anti-biofouling properties in aqueous medium2011

    • Author(s)
      Suzuki, H.; Murou, M.; Kitano, H.;Ohno, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B : Biointerfacse

      Volume: 84 Pages: 111-116

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] Image Printing on the Surface of Anti-biofouling Zwitterionic Polymer Brush by Ion Beam Irradiation2011

    • Author(s)
      Kitano, H.; Suzuki, H.; Kondo, T.; Sasaki, K.; Iwanaga, S.; Nakamura, M.; Ohno, K.; Saruwatari, Y.
    • Journal Title

      Macromol. Biosci.

      Volume: 11 Pages: 557-564

    • Related Report
      2013 Final Research Report
  • [Journal Article] 界面科学の基礎2011

    • Author(s)
      北野博巳
    • Journal Title

      CSJカレントレビュー04, 新しい局面を迎えた界面の分子科学-機能デザインと計測技術の展開, 日本化学会編

      Pages: 10-16

    • Related Report
      2013 Final Research Report
  • [Journal Article] 高分子材料近傍の水の構造と機能との相関2011

    • Author(s)
      源明誠, 北野博巳
    • Journal Title

      未来材料

      Volume: Vol.11, No.10 Pages: 40-46

    • Related Report
      2013 Final Research Report
  • [Journal Article] Recrystallization of Water in Non-Water-Soluble (Meth) Acrylate Polymers is Not Rare and is Not Devitrification2011

    • Author(s)
      Gemmei-Ide, M.; Ohya, A.; Kitano, H.
    • Journal Title

      J.Phys.Chem.B.

      Volume: 116 Issue: 6 Pages: 1850-1857

    • DOI

      10.1021/jp211473p

    • NAID

      120006395334

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Image Printing on the Surface of Anti-biofouling Zwitterionic Polymer Brush by Ion Beam Irradiation2011

    • Author(s)
      Kitano, H.; Suzuki, H.; Kondo, T.; Sasaki, K.; Iwanaga, S.; Nakamura, M.; Ohno, K.; Saruwatari, Y.
    • Journal Title

      Macromol.Biosci.

      Volume: 11 Issue: 4 Pages: 557-564

    • DOI

      10.1002/mabi.201000437

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperature-responsive Polymer Brush Constructed on a Glass Surface by Atom Transfer Radical Polymerization2010

    • Author(s)
      Kitaon, H.; Kondo, T.; Suzuki, H.; Ohno, K.
    • Journal Title

      J. Colloid Interface Sci.

      Volume: 345 Pages: 3250-331

    • Related Report
      2013 Final Research Report
  • [Journal Article] Molecular Recognition at the Exterior Surface of Zwitterionic Telomer Brush2010

    • Author(s)
      Kitano, H.; Suzuki, H.; Matsuura, K.; Ohno, K.
    • Journal Title

      Langmuir

      Volume: 26 Pages: 6767-6774

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Journal Article] Thermally Latent Water in a Polymer Matrix2010

    • Author(s)
      Gemmei-Ide, M.; Ohya, A.; Kitano, H.
    • Journal Title

      J. Phys. Chem. B

      Volume: 114 Pages: 4310-4312

    • NAID

      120006395333

    • Related Report
      2013 Final Research Report
  • [Journal Article] Direct Spectroscopic Observation of Binding of Sugars to Polymers Having Phenylboronic Acids Substituted with an ortho-Phenylazo group2010

    • Author(s)
      Okasaka, Y.; Kitano, H.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 79 Pages: 434-439

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Journal Article] Drying Dissipative Structures of Colloidal Crystals of Silica Spheres Coated with Polym er Brushes of Poly(carboxymethyl betaine)2010

    • Author(s)
      O kubo, T.; Suzuki, H.; Kitano, H.; Ohno, K.; Mizutani, M.; Tsuchida, A.
    • Journal Title

      Colloid Polymer Sci.

      Volume: 287 Pages: 115-1165

    • Related Report
      2013 Final Research Report
  • [Journal Article] Suitability of Synthetic Copolymer Membranes as a Human Skin Alternative for In Vitro Skin Permeation Testing2010

    • Author(s)
      Kiki, R.; Kimura, S.; Ueda, H.; Shimamura, T.; Numajiri, S.; Seki, T.; Juni, K.; Kitano, H.; Morimoto, Y.
    • Journal Title

      Alternative for In Vitro Skin Permeation Testing

      Volume: 15 Pages: 14-27

    • NAID

      10029747524

    • Related Report
      2013 Final Research Report
  • [Journal Article] Temperature-responsive Polymer Brush Constructed on a Glass Surface by Atom Transfer Radical Polymerization2010

    • Author(s)
      H.Kitano, T.Kondo, et al.
    • Journal Title

      J.Colloid Interface Sci.

      Volume: 345 Pages: 325-331

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermally Latent Water in a Polymer Matrix2010

    • Author(s)
      M.Gemmei-Ide, A.Ohya, H.Kitano
    • Journal Title

      J.Phys.Chem.B

      Volume: 114 Pages: 4310-4312

    • NAID

      120006395333

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drying Dissipative Structures of Colloidal Crystals of Silica Spheres Coated with Polymer Brushes of Poly(carboxymethyl betaine)2010

    • Author(s)
      T.Okubo, H.Suzuki, H.Kitano, K.Ohno, M.Mizutani, A.Tsuchida
    • Journal Title

      Colloid Polymer Sci.

      Volume: 287 Pages: 1155-1165

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suitability of Synthetic Copolymer Membranes as a Human Skin Alternative for In Vitro Skin Permeation Testing2010

    • Author(s)
      R.Kiki, S.Kimura, H.Ueda, T.Shimamura, S.Numajiri, T.Seki, K.Juni, H.Kitano, Y.Morimoto
    • Journal Title

      Alternatives to Animal Testing and Experimentation

      Volume: 15 Pages: 14-27

    • NAID

      10029747524

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 和周波発生法で観た高分子ブラ近傍の水の構造2011

    • Author(s)
      北野博巳・近藤卓也・室生賢伸・野村浩二・源明誠・野口秀典・魚崎浩平・大野工司・猿渡欣幸
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学津島キャンパス
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ポリ(メタ)アクリレートブラシ表面へのタンパク質吸着と線維芽細胞の付着特性の相関2011

    • Author(s)
      上條典昭・源明誠・北野博巳
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] スルホベタインポリマーの電荷間距離と生?適合性との相関2011

    • Author(s)
      斉藤翔・石原和幸・源明誠・北野博巳
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 硫酸化糖担持高分子ブラシ表面におけるベータアミロイドの挙動解析2011

    • Author(s)
      鎌田知宏・斉藤大輔・源明誠, 北野博巳
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular Recognition at the Exterior Surface of Polymer Brush2010

    • Author(s)
      H.Kitano, H.Suzuki, et al.
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Book] 高い抗血栓性を持つ材料の開発2014

    • Author(s)
      源明 誠, 北野博巳
    • Publisher
      株式会社技術情報協会
    • Related Report
      2013 Final Research Report
  • [Book] 温度可変赤外分光法による固体高分子中の水の相転移挙動の評価「IR分析テクニック事例集」2013

    • Author(s)
      源明 誠, 北野博巳
    • Publisher
      株式会社技術情報協会
    • Related Report
      2013 Final Research Report
  • [Book] 「IR分析に関する技術資料」 9章 24節:温度可変赤外分光法による固体高分子中の水の相転移挙動の評価2013

    • Author(s)
      源明 誠・北野博巳(分担執筆)
    • Total Pages
      785
    • Publisher
      株式会社 技術情報協会
    • Related Report
      2013 Annual Research Report
  • [Book] 双性イオン型高分子シランカップリング剤とその応用2012

    • Author(s)
      北野博巳, 李黎夫, 中路正
    • Publisher
      サイエンス&テクノロジー株式会社
    • Related Report
      2013 Final Research Report
  • [Book] シランカップリング剤の効果と使用方法2012

    • Author(s)
      北野博巳,李黎夫,中路正
    • Total Pages
      15
    • Publisher
      サイエンス&テクノロジー株式会社
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 光分解性材料、基板およびそのパターニング方法2012

    • Inventor(s)
      北野博巳、中路正、源明誠、岸岡高広、木村茂雄、広井佳臣、臼井友輝
    • Industrial Property Rights Holder
      国立大学法人富山大学、日産化学株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-10-11
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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