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Development of real time SPECT system for BNCT

Research Project

Project/Area Number 22360405
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nuclear engineering
Research InstitutionOsaka University

Principal Investigator

MURATA Isao  大阪大学, 工学(系)研究科(研究院), 教授 (30273600)

Co-Investigator(Kenkyū-buntansha) MIYAMARU Hiroyuki  大阪府立大学, 地域連携研究機構, 准教授 (80243187)
KATO Itsuro  大阪大学, 大学院歯学研究科, 助教 (60314390)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
KeywordsBNCT / SPECT / CdTe / 478keV / 治療効果 / リアルタイム / ホウ素 / 3次元イメージ / アレー型 / 10B(n,α)反応 / ホウ素中性子補足療法 / CdTe検出器 / ガンマ線 / ホウ素中性子捕捉療法
Outline of Final Research Achievements

Boron Neutron Capture Therapy (BNCT) is a new cancer therapy. Now it is in a phase of clinical test. Though this is a very much promising cancer treatment, there are some unsolved problems. One of them is that the treatment effect cannot be known in real time. In this study, a CdTe semiconductor detector was used to realize a SPECT system for BNCT. By measuring emitted gamma-rays via boron neutron capture reaction in real time, a three dimensional image of BNCT treatment can be obtained by using a SPECT technology. Basic theoretical studies for it were carried out and basic requirements were made clear. And basic performance of one and two CdTe element devices was examined to confirm the validity of the CdTe detector system. In future, an array-type CdTe detector for BNCT-SPECT would be expected.

Report

(5 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2015 2014 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Study on Measuring Device Arrangement of Array-type CdTe Detector for BNCT-SPECT2015

    • Author(s)
      Masanobu Manabe, Soichiro Nakamura, Isao Murata
    • Journal Title

      Reports of Practical Oncology and Radiotherapy

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization Measurement of A Thick CdTe Detector for BNCT-SPECT - Detection Efficiency and Energy Resolution -2014

    • Author(s)
      I. Murata, S. Nakamura, M. Manabe, H. Miyamaru, I. Kato
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 88 Pages: 129-133

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Precise Numerical Simulation of Gamma-ray Pulse Height Spectrum Measured with a CdTe Detector Designed for BNCT-SPECT2012

    • Author(s)
      Soichiro NAKAMURA, Taiki MUKAI, Masanobu MANABE, Isao MURATA
    • Journal Title

      Progress in Nucl. Sci. Technol.

      Volume: 3 Pages: 52-55

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of A Thick CdTe Detector for BNCT-SPECT2011

    • Author(s)
      I.Murata, et al
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1706-1709

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility Study on BNCT-SPECT Using A CdTe Detector2011

    • Author(s)
      I.Murata, et al
    • Journal Title

      Progress in Nuclear Science and Technology

      Volume: 1 Pages: 267-270

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of CdTe Detector for BNCT-SPECT2010

    • Author(s)
      T.Mukai, I.Murata, et al
    • Journal Title

      JAEA-Conf 2010-005

      Volume: 005 Pages: 75-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cross Talk Experiment of Array-type CdTe Detector for BNCT-SPECT -Experimental design -2014

    • Author(s)
      Masanobu Manabe*, Fuminobu Sato, Isao Murata
    • Organizer
      2014 Symposium on Nuclear Data
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] BNCT-SPECT用2素子CdTe検出器の基本特性及び非同時計測の可能性2014

    • Author(s)
      真鍋 正伸、佐藤 文信、村田 勲
    • Organizer
      第11回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      大阪大学
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2013 Annual Research Report
  • [Presentation] Basic property of array-type CdTe detector for BNCT-SPECT -Measurement and analysis of anti-coincidence event-2014

    • Author(s)
      Masanobu Manabe*, Fuminobu Sato, Isao Murata
    • Organizer
      16th International Conference on Neutron Capture Therapy
    • Place of Presentation
      ヘルシンキ、フィンランド
    • Year and Date
      2014-06-15 – 2014-06-20
    • Related Report
      2013 Annual Research Report
  • [Presentation] Study on Measuring Device Arrangement of Array-type CdTe Detector for BNCT-SPECT2013

    • Author(s)
      Masanobu Manabe, Soichiro Nakamura, Isao Murata
    • Organizer
      7th Young Researchers' Boron Neutron Capture Therapy Meeting
    • Place of Presentation
      Granada, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] Separate measurement of 478keV and annihilation gamma-rays by CdTe detector for BNCT-SPECT2013

    • Author(s)
      Masanobu Manabe, Soichiro Nakamura, Isao Murata
    • Organizer
      7th International Symposium on Radiation Safety and Detection Technology
    • Place of Presentation
      Sanya, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Present Status of BNCT-SPECT Development with CdTe Detector2013

    • Author(s)
      Masanobu Manabe, Soichiro Nakamura, Isao Murata
    • Organizer
      The 2013 Symposium on Nulcear Data
    • Place of Presentation
      Tsuruga, Fukui, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization Test of CdTe Detector Element Designed and Developed for BNCT-SPECT2011

    • Author(s)
      S.Nakamura, et al
    • Organizer
      2011 Symposium on Nuclear Data
    • Place of Presentation
      Tokai-mura, Ibaraki-ken
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of A Thick CdTe Detector for BNCT-SPECT2010

    • Author(s)
      I.Murata, et al
    • Organizer
      14^<th> International Congress on Neutron Capture Therapy
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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