|Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Diacylglycerol (DG) kinase has ten isozymes. We have recently found that DGK isozymes play pivotal roles in a wide variety of signal transduction pathways and are involved in pathogenesis of refractory diseases. Thus, we planed to reveal the mechanisms of regulation of signal transduction pathways by DGK isozymes and their novel patho-physiological functions. To this end, we first established several new analytical methods. Moreover, we obtained interesting results concerning the patho-physiological functions and the activity regulation of DGKα, γ, δ and η.