Elucidation of the metalloprotease-dependent onset of bloodcirculation
| Project/Area Number |
22370076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
SEHARA Atsuko 京都大学, 再生医科学研究所, 教授 (60209038)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | メタロプロテアーゼ / ADAM8 / 造血 / 血液循環 / 赤芽球 / 血管 / ゼブラフィッシュ / 細胞間接着 / 血管形成 / ノックアウトマウス / 筋再生 / インテグリン |
|---|
| Research Abstract |
We succeeded to observe the onset of erythrocyte circulation in livingzebrafish embryos. We could show that the start of blood circulation requires detachment oferythrocytes from blood vessels, in which process ADAM8 expressed in erythrocytes participate.Moreover, erythrocytes-blood vessel detachment dependent on ADAM8 was involved in the bloodvessel development. ADAM8 is expressed in inflammatory cells such as neutrophils and monocytesduring muscle regeneration in mice, and this protease is required for the removal of injuredmuscle.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Activity-dependent proteolytic cleavage of neuroligin-12012
Author(s)
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T.
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Journal Title
Neuron
Volume: 76(2)
Issue: 2
Pages: 410-422
DOI
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Peer Reviewed
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[Presentation] A Role of ADAM8 inthe Onset of Blood Circulation2011
Author(s)
Atsuo Iida, Kazuya Sakaguchi, AnnaTomozawa, Daigo Nishimura, Atsuo Kawahara,Atsuko Sehara-Fujisawa
Organizer
KEY Forum inDevelopmental Biology and RegenerativeMedicine-Supported by Global COE and IMEG
Place of Presentation
Kumamoto University熊本県
Year and Date
2011-09-09
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[Presentation] Metalloprotease-Dependent Onset of BloodCirculation In Zebrafish2010
Author(s)
Atsuo Iida, Kazuya Sakaguchi, Kiyoaki Sato,Hidetoshi Sakurai, Daigo Nishimura, Aya Iwaki,Makoto Kobayashi, Shigenobu Yonemura, AtsuoKawahara, and Atsuko Sehara-Fujisawa
Organizer
2nd Joint Meeting ofthe French and Japanese Societies forDevelopmental Biology
Place of Presentation
Paris, France
Year and Date
2010-05-16
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[Presentation] ENGRAFTMENT OF MOUSE FETAL MYOGENIC PROGENITORS INTO DYSTROPHIC MUSCLES
Author(s)
Sakai, Hiroshi, Sato, Takahiko, Sakurai, Hidetoshi, Hanaoka,Kazunori, Montarras, Didier, Buckingham, Margaret, Sehara-Fujisawa, Atsuko
Organizer
International Society for Stem Cell Research 10th Annual Meeting
Place of Presentation
神奈川県
Related Report
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[Presentation] ROLES OF ADAM8 FOR SKELETAL MUSCLE REGENERATION
Author(s)
Nishimura, Daigo, Sakai, Hiroshi, Sato, Takahiko, Iida, Atsuo, Sato, Fuminori, Bartsch, Jörg W., Sehara-Fujisawa, Atsuko
Organizer
International Society for Stem Cell Research 10th Annual Meeting
Place of Presentation
神奈川県
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