Evaluatuion ofstress-inducedactivation of quercetinand its multifunctional dynamics

• Project/Area Number: 22380077
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: The University of Tokushima
• Principal Investigator: TERAO Junji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60093275)
• Co-Investigator(Kenkyū-buntansha): KAWAI Yoshichika 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50380027) ; MUKAI Rie 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90547978)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 食品 / ストレス / 発現制御 / 分析化学 / シグナル伝達、筋萎縮 / β-βグルクロニダーゼ / 炎症 / シグナル伝達 / 筋萎縮 / 筋委縮 / β-グルクロニダーゼ / 分析科学 / 潰瘍性大腸炎 / フラボノイド

Research Abstract

This study was aimed to evaluate the multifunctional mechanism of quercetin as a antioxidative ingredient derived from plant foods. Rodent experiments demonstrated that dietary quercetin protects the intestinal mucosa of digestive tract, blood vessel, central nervous system and muscle tissue from oxidative stress by promoting the antioxidant enzyme expression as well asdirect ROS-scavenging and suppression of oxidant enzymes. It is implied that de-conjugation reaction by macrophage participates in these multifunction of dietary quercetin.

Research Products

• [Journal Article] Plasma HDL reduces nonesterified fatty acid hydroperoxides originating from oxidized LDL: a mechanism for its antioxidant ability (2013)
  • Author(s): Kotosai M., Shimada S., Kanda M., Matsuda N., Sekido K., Shimizu Y., Tokumura A.,Nakamura T., Murota K., Kawai Y., TeraoJ.
  • Journal Title: Lipids Volume: 48 Issue: 6 Pages: 569-578
  • DOI: 10.1007/s11745-013-3779-1
  • Peer Reviewed
• [Journal Article] Evaluation of theinhibitory effects of quercetin-related flavonoids and catechins on themonoamine oxide-se-A reaction in mouse brain mitochondria Journal of Agricultural (2012)
  • Author(s): Bandaruk Y., Mukai R., Kawamura T., Nemoto H Terao J.
  • Journal Title: Food Chemistry Volume: 60 Issue: 41 Pages: 10270-10277
  • DOI: 10.1021/jf303055b
  • Peer Reviewed
• [Journal Article] Prevention of disusemuscle atrophy by dietary ingestion of 8-prenylnaringenin in denervated mice (2012)
  • Author(s): Mukai R., Horikawa H., Fujikura Y., Kawamura T., Nemoto H., Nikawa T.
  • Journal Title: PLoS ONE Volume: 9 Issue: 9 Pages: e45048-e45048
  • DOI: 10.1371/journal.pone.0045048
  • Peer Reviewed
• [Journal Article] Effect of quercetin and its glucuronide metabolites upon 6-hydroxydopamineinduced oxidative damage in neuro-2a cells (2012)
  • Author(s): Mukai R., Kawabata K., Otsuka S., Ishisaka A., Kawai Y., Ji Z-S., Tsuboi H., Terao J.
  • Journal Title: Free Radi-cal Research Volume: 8 Pages: 1019-1028
  • Peer Reviewed
• [Journal Article] Effect of quercetin and its glucuronide metabolites upon 6-hydroxydopamine-induced oxidative damage in neuor-"a cells (2012)
  • Author(s): Mukai r., Kawabata K., Otsuka S., Ishisaka A., Kawai y., Ji Z-S., Tsuboi H., Terao J.
  • Journal Title: Free Radical Research Volume: (Epub)
  • Peer Reviewed
• [Journal Article] Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats (2011)
  • Author(s): Ishisaka A, et al
  • Journal Title: Free Radic Biol Med Volume: 51(7) Issue: 7 Pages: 1329-1336
  • DOI: 10.1016/j.freeradbiomed.2011.06.017
  • Peer Reviewed
• [Journal Article] Effect of quercetin and glucuroni-de metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria. (2011)
  • Author(s): S. Yoshino, Hara A, Sakakibara H, Kawabata K, Tokumura A, Ishisaka A, Kawai Y, Terao J
  • Journal Title: Nutrition Volume: 27 Issue: 7-8 Pages: 7-8
  • DOI: 10.1016/j.nut.2010.09.002
  • Peer Reviewed
• [Journal Article] Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo (2011)
  • Author(s): Terao J. Murota K, Kawai Y
  • Journal Title: Food and Function Volume: 2 Issue: 1 Pages: 11-17
  • DOI: 10.1039/c0fo00106f
  • Peer Reviewed
• [Journal Article] Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria (2011)
  • Author(s): S.Yoshino
  • Journal Title: Nutrition Volume: (In press(Epub))
  • Peer Reviewed
• [Presentation] A role of dietary flavonoids on oxidative stress in the central nervous system: attenuation of monoamine oxidase-A activity (2012)
  • Author(s): Terao J
  • Organizer: The １st Internationla Conference on Pharma and Food
  • Place of Presentation: 日本平ホテル(静岡県）
  • Invited
• [Presentation] Effectof prenylation on the bioavailability of dietary flavonoids (2012)
  • Author(s): Terao J
  • Organizer: International Society for Nutraceuticals and Functional Foods Annual Conference
  • Place of Presentation: Kona Beach Hotel (米国）
  • Invited
• [Presentation] マウス大腸粘膜の脂質ヒドロペルオキシド消去作用とルチン摂食の効果 (2012)
  • Author(s): 寺尾純二
  • Organizer: 第66回日本栄養食糧学会総会
  • Place of Presentation: 東北大学川内キャンパス(宮城県）
• [Presentation] 筋管細胞における遊離脂肪酸ヒドロペルオキシド誘導ユビキチンリガーゼ発現に対するケルセチンの抑制作用 (2012)
  • Author(s): 寺尾純二
  • Organizer: 平成24年度日本栄養食糧学科中国・四国支部大会
  • Place of Presentation: 愛媛大学農学部(愛媛県）
• [Presentation] Central nervous system : a possible target of dietary flavonoids (2011)
  • Author(s): J.Terao, A.Ishisaka, Y.Kawai
  • Organizer: ICoFF (FOod Factors)
  • Place of Presentation: Taipei, TAIWAN
  • Year and Date: 2011-11-21
• [Presentation] Potential of dietary flavonoids for the prevention of muscle atrophy (2011)
  • Author(s): J.Terao
  • Organizer: ISNFF (Neutraceuticals and Funtional Foods)
  • Place of Presentation: 札幌ロイトンホテル
  • Year and Date: 2011-10-16
• [Presentation] Dietary flavonoids as antioxidants and beyond antioxidants in target tissues (2011)
  • Author(s): J.Terao
  • Organizer: Eurofood 2011
  • Place of Presentation: Gdansk, POAND
  • Year and Date: 2011-07-06
• [Presentation] Functional food factors for the prevention of muscle atrophy (2011)
  • Author(s): J.Terao
  • Organizer: 2^<nd> NAPA meeting
  • Place of Presentation: Gyeongyu, KOREA
  • Year and Date: 2011-02-17
• [Presentation] Multitargets of dietary flavonoids in modulation of oxidative stress (2011)
  • Author(s): J.Terao
  • Organizer: International Symposium on Free Radical Research
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2011-01-22
• [Presentation] Central nervous system as a possible target of dietary quercetin and its metabolites (2010)
  • Author(s): J.Terao
  • Organizer: International Conference on Neutraceuticals and Functional Foods
  • Place of Presentation: Bali, INDONESIA
  • Year and Date: 2010-10-14
• [Presentation] Processing and cooking effects on bioavailability and bioefficacy of dietary flavonoids (2010)
  • Author(s): J.Terao
  • Organizer: Korean Society of Nutrition International Symposium
  • Place of Presentation: Seoul、KOREA
  • Year and Date: 2010-06-03
• [Book] Bioavailability of Flavonols and Flavones (2012)
  • Author(s): PIskula MK., Murota K., Terao J.
  • Publisher: CRC
• [Book] lavonoid and related compounds (Chapter 4. Bioavailability of Flavonols and Falvones (2012)
  • Author(s): M. Piskula, K. Murota, J. Terao
  • Publisher: CRC
• [Book] Bioavailability of Flavonols and Flavones(in Flavonoidsa and Related Compounds) (2012)
  • Author(s): Piskula MK
  • Total Pages: 15
  • Publisher: CRC press
• [Book] フラボノイド （Ｆｕｎｃｔｉｏｎａｌ Ｆｏｏｄ第19号） (2012)
  • Author(s): 寺尾純二
  • Total Pages: 7
  • Publisher: フジメディカル出版
• [Book] Flavonoid and related compounds (Chapter 4. Bioavailability of Flavonols and Falvones) (2012)
  • Author(s): M.Piskula, K.Murota, j.Terao
  • Total Pages: 15
  • Publisher: CRC press
• [Book] フラボノイド (Functional Food第19号)
  • Author(s): 寺尾純二
  • Publisher: フジメディカル