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Vertical transmission pattern of pathogens cause abortion of domestic animals

Research Project

Project/Area Number 22380158
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionGifu University

Principal Investigator

YASUHIRO TAKASHIMA  岐阜大学, 応用生物科学部, 准教授 (20333552)

Co-Investigator(Kenkyū-buntansha) OHYA Kenji  岐阜大学, 応用生物科学部, 准教授 (50402219)
高須 正規  岐阜大学, 応用生物科学部, 准教授 (00503327)
Co-Investigator(Renkei-kenkyūsha) TAKASU Masaki  岐阜大学, 応用生物科学部, 准教授 (00503327)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords胎盤 / 家畜 / トキソプラズマ / 垂直感染 / 潜伏感染 / 白血球 / 体内伝播
Research Abstract

In this study, the dissemination of intracellular pathogen from maternal blood flow to the placenta was revealed. Even in the case of pathogens, which preferencially infect to the placenta, drastical accumulation of the infected maternal leukocytes was not observed in the placenta. It may be because the lack of expression of molecules related with cell adhesion on the most surface layer of the placenta. Physical disruption of the layer must be important for vertical transmission of intracellular pathogens.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (3 results)

  • [Journal Article] CD44 mediated Hyaluronan adhesion of Toxoplasma gondii-infected leukocytes2014

    • Author(s)
      Hayashi T., Unno A., Baba M., Ohno T., Kitoh K. Takashima Y
    • Journal Title

      Parasitol. Int

      Volume: 63(2) Pages: 479-84

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD44 mediated hyaluronan adhesion of Toxoplasma gondii-infected leukocytes.2014

    • Author(s)
      Hayashi T, Unno A, Baba M, Ohno T, Kitoh K, Takashima Y.
    • Journal Title

      Parasitol Int.

      Volume: 63 Issue: 2 Pages: 479-84

    • DOI

      10.1016/j.parint.2013.10.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and dynamics of antibodies against NcSAG1 and NcGRA7 antigens of Neospora caninum in cattle during the gestation period2013

    • Author(s)
      Takashima Y., Takasu M., Yanagimoto I., Hattori N., Batanova T., Nishikawa Y., Kitoh K.
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 75(11) Pages: 1413-8

    • NAID

      120006342280

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii tachyzoite-infected peripheral blood mononuclear cells are enriched in mouse lungs and liver2013

    • Author(s)
      Unno A., Kachi S., Batanova T., Ohno T, Elhawary N., Kitoh K., Takashima Y
    • Journal Title

      Exp. Parasitol

      Volume: 134 Pages: 160-164

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii tachyzoite-infected peripheral blood mononuclear cells are enriched in mouse lungs and liver.2013

    • Author(s)
      Unno A, Kachi S, Batanova TA, Ohno T, Elhawary N, Kitoh K, Takashima Y.
    • Journal Title

      Exp Parasitol

      Volume: 134 Issue: 2 Pages: 160-164

    • DOI

      10.1016/j.exppara.2013.03.006

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and dynamics of antibodies against NcSAG1 and NcGRA7 antigens of Neospora caninum in cattle during the gestation period.2013

    • Author(s)
      Takashima Y, Takasu M, Yanagimoto I, Hattori N, Batanova T, Nishikawa Y, Kitoh K.
    • Journal Title

      J Vet Med Sci.

      Volume: 75 Pages: 1413-1418

    • NAID

      120006342280

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス胎盤におけるトキソプラズマ感染白血球の挙動2013

    • Author(s)
      高島康弘
    • Organizer
      日本寄生虫学会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Toxoplasma gondii 感染THP-1 細胞におけるCD44 発現パターンの比較2012

    • Author(s)
      林武志, 鬼頭克也, 高島康弘
    • Organizer
      第154回日本獣医学会
    • Place of Presentation
      岩手大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Toxoplasma gondii感染THP-1細胞におけるCD44発現パターンの比較2012

    • Author(s)
      林武志
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手大学
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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