Pathophysiological significance of the factor which enhances the action of oxidized LDL, platelets, and leukocytes on vascular wall.
Project/Area Number |
22390051
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
SAWAMURA Tatsuya 独立行政法人国立循環器病研究センター, 研究所, 部長 (30243033)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
Keywords | 酸化 / LDL / LOX-1 / 血小板 / 血栓 / 酸化LDL受容体 / 動脈硬化 / 炎症 / 酸化LDL / 受容体 |
Research Abstract |
We have identified a co-factor which enhances the binding of oxidized LDL and platelets to LOX-1, an oxidized LDL receptor, promoting blood coagulating reaction in LOX-1 dependent manner. The interaction between LOX-1 and the co-factor might be a key reaction to determine the onset and progression of atherothrombotic diseases.
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Report
(4 results)
Research Products
(96 results)
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[Journal Article] Davidge, S.T. and Kenny, L.C. : Lectin-like oxidized low-density lipoprotein l(LOX-l) receptor inhibition protects against pre-elamspsia plasma mediated vascular dysfunction.2013
Author(s)
English, F.A., McCarthy, F.P., McSweeney, C.L., Quon, A.L., Morton, J.S., Sawamura, T.
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Journal Title
Am J Hypertens
Volume: 26
Pages: 279-286
DOI
Related Report
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[Journal Article] Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort : The Suita study.2013
Author(s)
Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.
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Journal Title
J Atheroscler Thromb
Volume: 20
Pages: 195-203
DOI
Related Report
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[Journal Article] Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries : Therapeutic effects of ezetimibe.2012
Author(s)
Sato, K., Nakano, K., Katsuki, S., Matoba, T., Osada, K., Sawamura, T., Sunagawa, K. and Egashira, K.
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Journal Title
J Atheroscler Thromb
Volume: 19
Pages: 986-998
DOI
Related Report
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[Journal Article] Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia.2012
Author(s)
Morton, J.S., Abdalvand, A., Jiang, Y., Sawamura, T., Uwiera, R.R. and Davidge, S.T.
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Journal Title
Hypertension
Volume: 59
Pages: 1014-1020
DOI
Related Report
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[Journal Article] Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.2012
Author(s)
Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.
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Journal Title
Arthritis Rheum
Volume: 64
Pages: 1024-1034
DOI
Related Report
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[Journal Article] Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis2012
Author(s)
Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T., Nakamura, T.
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Journal Title
Arthritis Rheum
Volume: 64
Pages: 1024-1034
DOI
Related Report
Peer Reviewed
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[Journal Article] Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.2011
Author(s)
Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.
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Journal Title
Clin Chem
Volume: 57
Pages: 1398-1405
DOI
Related Report
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[Journal Article] An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB)-utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.2011
Author(s)
Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.
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Journal Title
J Atheroscler Thromb
Volume: 18
Pages: 818-828
DOI
Related Report
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[Journal Article] LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model.2011
Author(s)
Wu, Z., Sawamura, T., Kurdowska, A.K., Ji, H.L., Idell, S. and Fu, J.
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Journal Title
Infect Immun
Volume: 79
Pages: 2865-2870
DOI
Related Report
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[Journal Article] Procyanidins are potent inhibitors of LOX-1 : a new player in the French Paradox.2011
Author(s)
Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.
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Journal Title
Proc Jpn Acad Ser B Phys Biol Sci
Volume: 87
Pages: 104-113
DOI
Related Report
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[Journal Article] Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation2011
Author(s)
Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R., Sawamura, T.
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Journal Title
Clin Chem
Volume: 57
Pages: 1398-1405
DOI
Related Report
Peer Reviewed
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[Journal Article] An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB)-utilization of anti-LOX-1 single-chain antibody fused to apoB fragment2011
Author(s)
Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R., Sawamura, T.
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Journal Title
J Atheroscler Thromb
Volume: 18
Pages: 818-828
DOI
Related Report
Peer Reviewed
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[Journal Article] LOX-1 deletion improves neutrophil responses, enhances bacterial clearance and reduces lung injury in a murine polymicrobial sepsis model2011
Author(s)
Wu, Z., Sawamura, T., Kurdowska, A.K., Ji, H.L., Idell, S., Fu, J.
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Journal Title
Infect Immun
Volume: 79
Pages: 2865-2870
DOI
Related Report
Peer Reviewed
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[Journal Article] LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.2010
Author(s)
Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.
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Journal Title
Clin Chem
Volume: 56
Pages: 550-558
DOI
Related Report
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[Journal Article] Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.2010
Author(s)
Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.
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Journal Title
Lipids
Volume: 45
Pages: 329-335
DOI
Related Report
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[Journal Article] LOX-1 mediates vascular lipid retention under hypertensive state.2010
Author(s)
Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H., Sawamura, T.
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Journal Title
J Hypertens
Volume: 28
Pages: 1273-1280
Related Report
Peer Reviewed
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[Journal Article] Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress.2010
Author(s)
Kishimoto, H., Akagi, M., Zushi, S., Teramura, T., Onodera, Y., Sawamura, T., Hamanishi, C.
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Journal Title
Osteoarthritis Cartilage
Volume: 18
Pages: 1284-1290
Related Report
Peer Reviewed
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[Journal Article] Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development.2010
Author(s)
Qiu, Y., Yanase, T., Hu, H., Tanaka, T., Nishi, Y., Liu, M., Sueishi, K., Sawamura, T., Nawata, H.
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Journal Title
Endocrinology
Volume: 151
Pages: 3307-3316
Related Report
Peer Reviewed
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[Journal Article] Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice.2010
Author(s)
Takanabe-Mori, R., Ono, K., Sowa, N., Wada, H., Takaya, T., Horie, T., Satoh-Asahara, N., Shimatsu, A., Fujita, M., Sawamura, T., Hasegawa, K.
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Journal Title
Biochem Biophys Res Commun
Volume: 398
Pages: 576-580
Related Report
Peer Reviewed
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[Presentation] Serum level of LOX-1 ligand containing apoB (LAB) was associated with an increased risk of subclinical atherosclerosis in us white and Japanese men2012
Author(s)
Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki,T., Kim Sutton-Tyrrell, Daniel Edmundowicz, Murakami, Y., Miura, K., Lewis H Kuller,Ueshima,H.
Organizer
XVI International Symposium on Atherosclerosis
Place of Presentation
シドニー
Year and Date
20120325-29
Related Report
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[Presentation] Serium level of LOX-1 ligand containing apoB (LAB) was associated with an increased risk of subclinical atherosclerosis in us white and Japanese men2012
Author(s)
Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Tyrrell, K.S., Edmundowicz, D., Murakami, Y., Miura, K., L.Kuller, L.H., Ueshima, H
Organizer
XVI International Symposium on Atherosclerosis
Place of Presentation
シドニー
Year and Date
20120325-20120329
Related Report
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[Presentation] C-Reactive protein binds to LOX-1 and causes vascular dysfunction via complement activation2010
Author(s)
Fujita, Y., Otsui, K., Kakino, A.,Yamaguchi, S.,Sato, Y., Yoshimoto, R., SawamuraX
Organizer
第14回国際SHRシンポジウム
Place of Presentation
モントリオール
Year and Date
20100922-27
Related Report
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[Presentation] C-Reactive protein binds to LOX-1 and causes vascular dysfunction via complement activation.2010
Author(s)
Fujita, Y., Otsui, K., Kakino, A., Yamaguchi, S., Sato, Y., Yoshimoto, R., Sawamura, T.
Organizer
第14回国際SHRシンポジウム
Place of Presentation
Montreal,Canada
Year and Date
20100922-20100927
Related Report
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[Presentation] LOX-1 is involved in the complement activation by endogenous C-Reactive protein and myocardial reperfusion injury2010
Author(s)
Fujita, Y., Otsui, K., Kakino, A.,Yamaguchi, S., Sato,Y., Yoshimoto, R.,Sawamura,T.
Organizer
15th World Cogress on Heart Disease
Place of Presentation
バンクーバー
Year and Date
20100724-28
Related Report
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[Presentation] LOX-1 is involved in the complement activation by endogenous C-Reactive protein and myocardial reperfusion injury.2010
Author(s)
Fujita, Y., Otsui, K., Kakino, A., Yamaguchi, S., Sato,Y., Yoshimoto, R., Sawamura, T.
Organizer
15th World Cogress on Heart Disease
Place of Presentation
Vancouver, Canada
Year and Date
20100724-20100728
Related Report
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[Presentation] The effect of LOX-1 and LOX-1 ligands containing ApoB on the incidence of coronary heart disease and stroke in an 11-year population-based cohort study : The Suita study.2010
Author(s)
Okamura, T., Inoue, N., Kokubo, Y., Fujita, Y., Sato, Y., Watanabe, M., Sawamura, T.
Organizer
第42回日本動脈硬化学会
Place of Presentation
岐阜
Year and Date
20100715-20100716
Related Report
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[Presentation] The effect of LOX-1 and LOX-1 ligands containing ApoB on the incidence of coronary heart disease and stroke in an 11-year population-based cohort study: The Suita study2010
Author(s)
Okamura, T., Inoue, N., Kokubo, Y, Fujita, Y, Sato, Y., Watanabe, M。Sawamura,T.
Organizer
第42回日本動脈硬化学会
Place of Presentation
岐阜
Year and Date
20100715-16
Related Report
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