Development of prevention methods for hepatitis C - related liver tumor focusing function of nuclear receptor PPAR

• Project/Area Number: 22390060
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Shinshu University
• Principal Investigator: AOYAMA Toshifumi 信州大学, 医学系研究科, 教授 (50231105)
• Co-Investigator(Kenkyū-buntansha): HARA Atsushi 信州大学, 医学系研究科, 准教授 (70126697)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 分子腫瘍学 / C 型肝炎 / 肝発癌 / PPAR / アンタゴニスト / 中性脂肪 / HCVコア蛋白 / C型肝炎 / HCC / 脂肪肝 / コア蛋白 / フィブレート / EPA / PPAR活性化 / ミトコンドリア障害 / フィブラート / 酸化ストレス

Research Abstract

Presentation of hepatitis C virus - related liver tumor was found that activation of nuclear receptor: PPAR exerts as an essential factor. In this study, several attempts to prevent occurrence of liver tumor by means of PPAR antagonist (MK886) etc. were done, using transgenic mice expressing hepatitis C virus core protein. Administration of high dose MK886 (40 mg/kg/day) was confirmed to completely prevent occurrence of liver tumor, however, MK886 could cause fatal toxicity in some mice.

Research Products

• [Journal Article] Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels. (2012)
  • Author(s): Kamijo Y, Wang LX, Matsumoto A,Nakajima T, Hashimoto K, Higuchi M, Kyogashima M, Aoyama T, Hara A
  • Journal Title: Clin Exp Nephrol Volume: 16 Issue: 6 Pages: 959-967
  • DOI: 10.1007/s10157-012-0634-2
  • NAID: 10031145928
  • Peer Reviewed
• [Journal Article] Attenuation of Kidney Injuries Maintains Serum Sulfatide Levels Dependent on Hepatic Synthetic Ability: A Possible Involvement of Oxidative Stress (2012)
  • Author(s): Sheng XN, Nakajima T, Wang LX, Zhang XW, Kamijo Y, Takahashi K, Tanaka N, Sugiyama E, Kyogashima M, Aoyama T, Hara A
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 227 Issue: 1 Pages: 1-12
  • DOI: 10.1620/tjem.227.1
  • NAID: 10030613055
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] PPARα activation protects against anti-Thy1 nephritis by suppressing glomerular NF-κB signaling (2012)
  • Author(s): Hashimoto K, Kamijo Y, Nakajima T, Harada M, Higuchi M, Ehara T, Shigematsu H, Aoyama T
  • Journal Title: PPAR Res Volume: 2012 Pages: 976089-976089
  • DOI: 10.1155/2012/976089
  • Peer Reviewed
• [Journal Article] Hepatic cerebroside sulfotransferase is induced by PPARα activation in mice (2012)
  • Author(s): Kimura T, Nakajima T, Kamijo Y, Tanaka N, Wang L, Hara A, Sugiyama E, Tanaka E, Gonzalez FJ, Aoyama T
  • Journal Title: PPAR Res Volume: 2012 Pages: 174932-174932
  • DOI: 10.1155/2012/174932
  • Peer Reviewed
• [Journal Article] Fatty acid accumulation and resulting PPARα activation in fibroblasts due to trifunctional protein deficiency (2012)
  • Author(s): Wakabayashi M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Tian YY, Kimura T, Aoyama T
  • Journal Title: PPAR Res Volume: 2012 Pages: 371691-371691
  • DOI: 10.1155/2012/371691
  • Peer Reviewed
• [Journal Article] Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARαin mice. (2012)
  • Author(s): Nakagawa T, Ramdhan DH, Tanaka N, Naito H, Tamada H, Ito Y, Li YF, Hayashi Y, Yamagishi N, Yanagiba Y, Aoyama T, Gonzalez FJ, Nakajima T
  • Journal Title: Arch Toxicol Volume: 86 Issue: 1 Pages: 63-74
  • DOI: 10.1007/s00204-011-0704-3
  • Peer Reviewed
• [Journal Article] PPARα is down-regulated following liver transplantation in mice. (2012)
  • Author(s): Nakagawa K, Tanaka N, Morita M, Sugioka A, Miyagawa S, Gonzalez FJ, Aoyama T
  • Journal Title: J Hepatol Volume: 56 Issue: 3 Pages: 586-594
  • DOI: 10.1016/j.jhep.2011.08.021
  • Peer Reviewed
• [Journal Article] Down-regulation of SREBP-lc is associated with the development of bur ned-out NASH (2010)
  • Author(s): 青山俊文
  • Journal Title: J Hepatology Volume: 53 Pages: 724-731
  • Peer Reviewed
• [Journal Article] Effect of bezafibrate on hepatic oxidative stress (2010)
  • Author(s): 青山俊文
  • Journal Title: Redox Report Volume: 15 Pages: 123-130
  • Peer Reviewed
• [Book] 目で見る解剖と生理・11巻消化系II (2010)
  • Author(s): 青山俊文
  • Total Pages: 35
  • Publisher: 医学映像教育センター