Glucose and lipid metabolism regulated by the endoplasmic reticulum signaling
| Project/Area Number |
22390061
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OYADOMARI Seiichi 徳島大学, 疾患プロテオゲノム研究センター, 教授 (90502534)
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| Co-Investigator(Kenkyū-buntansha) |
HOSODA Akira 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (50379559)
OYADOMARI Miho 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (00596158)
MIYAKE Masato 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (30588976)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 小胞体 / ストレス / PERK / eIF2α / 代謝 / 骨格筋 / 褐色脂肪細胞 / 糖代謝 / 脂質代謝 / 体内時計 / 糖尿病 / eIF2αリン酸化 / トランスジェニックマウス / 膵β細胞 / 骨格筋細胞 / 脂肪細胞 |
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| Research Abstract |
The unfolded protein response (UPR) signal is involved in metabolic regulation. However, the significance of the protein kinase R-like endoplasmic reticulum kinase (PERK) signaling pathway in metabolism remains to be clarified. Our study showthat skeletal muscle-specific PERK activation promotes energy consumption in brown adipose tissue (BAT) and suppresses diet-induced obesity. We reveal that when eIF2αis phosphorylated by PERK, it acts through activating transcription factor 4 (ATF4) to stimulate energy consumption by inducing secretion of the myokine FGF21.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses2011
Author(s)
Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, HasegawaY, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H
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Journal Title
Circulation
Volume: 124
Issue: 7
Pages: 830-839
DOI
Related Report
Peer Reviewed
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