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Study on new approach to effective acquirement and the maintaining mechanisms of prostate cancer stem cell.

Research Project

Project/Area Number 22390070
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNara Medical University

Principal Investigator

KONISHI Noboru  奈良県立医科大学, 医学部, 教授 (20145832)

Co-Investigator(Kenkyū-buntansha) SHIMADA Keiji  奈良県立医科大学, 医学部, 講師 (90336850)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords前立腺 / 癌幹細胞 / 癌化 / CD133 / CD44 / syndecan-1 / 前立腺癌 / quiecence / Syndecan-1 / 抗癌剤ストレス
Research Abstract

Increasing evidence suggests that tumor-initiating cells (TIC) contribute to the development of prostate cancer. We identify syndecan-1 as a key molecule for maintaining the stability of prostate cancer TIC. Holoclones harboring biological properties of stemness overexpressed syndecan-1, but showed reduced expression of NADPH oxidase and synthesis of hydrogen peroxide and oxygen radicals. In the transgenic adenocarcinoma of the mouse prostate (TRAMP) model of prostate cancer, early intervention with a syndecan-1 inhibitor (OGT2115) or syndecan-1 RNAi reduced the cancer incidence and the number of c-kit+/CD44+ cells. Syndecan-1 immunopositivity in prostate cancer cells was significantly associated with biochemical recurrence after radical prostatectomy. Taken together, syndecan-1 contributes to prostatic carcinogenesis by maintaining TIC, and might be a novel target molecule for effective cancer therapy.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (49 results)

All 2012 2011 2010

All Journal Article (28 results) (of which Peer Reviewed: 25 results) Presentation (18 results) Book (3 results)

  • [Journal Article] Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in patients Who Underwent Retropubic Radical Prostatectomy2012

    • Author(s)
      Tanaka, N., Fujimoto, K., Hirayama, A., Nakai, Y., Chihara, Y., Anai, S., Tomioka, A., Shimada, K., Konishi, N., Hirao, Y
    • Journal Title

      Advance in Urology

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phyllodes tumor of the prostate2012

    • Author(s)
      Fujii, T., Shimada, K., Tanaka, N., Fujimoto, K., Konishi, N
    • Journal Title

      Pathol Int

      Volume: 62(3) Pages: 204-208

    • NAID

      10031185190

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012

    • Author(s)
      Asai, O., Nakatani, K., Konishi, N.
    • Journal Title

      Kidney Int

      Volume: 81 Pages: 539-547

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD138 を介する前立腺癌進展メカニズムの解析-tumor initiating cellsへの影響-2012

    • Author(s)
      島田啓司、藤井智美、穴井智、藤本清秀、小西 登
    • Journal Title

      泌尿器外科

      Volume: 25 Pages: 1597-1600

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calculated tumor volume is an independent predictor of biochemical recurrence in patients who underwent retropubic radical prostatectomy.2012

    • Author(s)
      Tanaka, N., Fujimoto, K., Hirayama, A., Nakai, Y., Chihara, Y., Anai, S., Tomioka, A., Shimada, K., Konishi, N., Hirao, Y.
    • Journal Title

      Advance in Urology

      Volume: 2012 Pages: 7-7

    • DOI

      10.1155/2012/204215

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phyllodes tumor of the prostate.2012

    • Author(s)
      Fujii, T., Shimada, K., Tanaka, N., Fujimoto, K., Konishi, N.
    • Journal Title

      Pathol Int

      Volume: 62 Issue: 3 Pages: 204-208

    • DOI

      10.1111/j.1440-1827.2012.02796.x

    • NAID

      10031185190

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased renalα-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012

    • Author(s)
      Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
    • Journal Title

      Kidney Int

      Volume: 81(6) Issue: 6 Pages: 539-47

    • DOI

      10.1038/ki.2011.423

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD138を介する前立腺癌進展メカニズムの解析 -tumor initiating cellsへの影響-2012

    • Author(s)
      島田啓司、藤井智美、穴井智、藤本清秀、小西 登
    • Journal Title

      泌尿器外科

      Volume: 25 Pages: 1597-1600

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury2011

    • Author(s)
      Hotta, K., Sho, M., Yamato, I., Shimada, K., Harada, H., Akahori, T., Nakamura, S., Konishi, N., Yagita, H., Nonomura, K., Nakajima, Y
    • Journal Title

      Kidney Int

      Volume: 79 Pages: 151-153

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌-基礎・臨床研究のアップデート- I .基礎 前立腺癌の病理 TNM 分類と取扱い規約の諸問題2011

    • Author(s)
      島田啓司,小西 登
    • Journal Title

      日本臨牀

      Volume: 69 Pages: 31-35

    • Related Report
      2012 Final Research Report
  • [Journal Article] ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer2011

    • Author(s)
      Tasaki. M., Shimada. K., Kimura. H., Tsujikawa. K., Konishi. N
    • Journal Title

      Br J Cancer

      Volume: 104 Pages: 700-706

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線抵抗性前立腺癌に対する分子標的治療の試み2011

    • Author(s)
      穴井 智, 井上剛志, 池田朋博, 三宅牧人, 千原良友, 田中宣道, 藤本清秀, 平尾佳彦, 島田啓司, 小西 登
    • Journal Title

      泌尿器外科

      Volume: 24 Pages: 1263-1265

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of minocycline on hind-limb motor function and gray and white matter injury after spinal cord ischemia in rats2011

    • Author(s)
      Takeda, M., Kawaguchi, M., Kumatoriya, T., Horiuchi, T., Watanabe, K., Inoue, S., Konishi, N., Furuya, H
    • Journal Title

      Spine

      Volume: 36 Pages: 1919-1924

    • NAID

      10030901085

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk-stratified survival rates and predictors of biochemical recurrence after radical prostatectomy in a Nara, Japan, cohort study2011

    • Author(s)
      Tanaka, N., Fujimoto, K., Hirayama, A., Torimoto, K., Okajima, E., Tanaka, M., Miyake, M., Shimada, K., Konishi, N., Hirao, Y
    • Journal Title

      Int J Clin Oncol

      Volume: 16 Pages: 553-559

    • NAID

      10030246925

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma2011

    • Author(s)
      Hotta, K., Sho, M., Fujimoto, K., Shimada, K., Yamato, I., Anai, S., Konishi, N., Hirao, Y., Nonomura, K., Nakajima, Y
    • Journal Title

      Br J Cancer

      Volume: 105 Pages: 1191-1196

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2alpha contributes to human bladder cancer cell survival2011

    • Author(s)
      Shimada, K., Anai, S., Marco DA, Fujimoto, K., Konishi, N
    • Journal Title

      BMC Urol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk-stratified survival rates and predictors of biochemical recurrence after radical prostatectomy in a Nara, Japan, cohort study2011

    • Author(s)
      Tanaka, N., Fujimoto, K., Konishi, N., et al
    • Journal Title

      Int J Clin Oncol

      Volume: 16巻 Pages: 553-559

    • NAID

      10030246925

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2alpha contributes to human bladder cancer cell survival2011

    • Author(s)
      Shimada, K., Konishi, N., et al
    • Journal Title

      BMC Urol

      Volume: VOL.11 Pages: 8-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌(第2版)-基礎・臨床研究のアップデート-I.基礎前立腺癌の病理TNM分類と取扱い規約の諸問題2011

    • Author(s)
      島田啓司, 小西登
    • Journal Title

      日本臨牀

      Volume: 69巻 Pages: 31-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma2010

    • Author(s)
      Shimada, K., Nakamura, M., De Velasco MA, Tanaka, M., Ouji, Y., Miyake, M., Fujimoto, K., Hirao, K., Konishi, N
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 155-160

    • NAID

      10027199949

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Posttreatment but not pretreatment with selective beta-adrenoreceptor 1 antagonists provides neuroprotection in the hippocampus in rats subjected to transient forebrain ischemia2010

    • Author(s)
      Iwata, M., Inoue, S., Kawaguchi, M., Nakamura, M., Konishi, N., Furuya, H
    • Journal Title

      Anesth Analg

      Volume: 110 Pages: 1126-1132

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 第11 章 尿管・膀胱・尿道 乳頭腫2010

    • Author(s)
      島田啓司, 小西 登
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 210-211

    • Related Report
      2012 Final Research Report
  • [Journal Article] 第12 章 男性生殖器 神経周囲浸潤2010

    • Author(s)
      小西 登
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 236-237

    • Related Report
      2012 Final Research Report
  • [Journal Article] Syndecan-1(CD138)を介した前立腺癌進展メカニズム2010

    • Author(s)
      島田啓司, 小西 登
    • Journal Title

      泌尿器外科

      Volume: 23 Pages: 1011-1014

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ステージC前立腺癌症例における根治的前立腺全摘除術、外部照射放射線治療およびホルモン治療の治療成績2010

    • Author(s)
      田中宣道, 冨岡厚志, 仲川嘉紀, 林美樹, 百瀬均, 三馬省二, 岡島英二郎, 藤本清秀, 平尾佳彦, 浅川勇雄, 玉本哲郎, 長谷川正俊, 小西 登
    • Journal Title

      泌尿器外科

      Volume: 23 Pages: 1079-1082

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Snail1 is stabilized byO-GlcNAc modification in hyperglycaemic condition2010

    • Author(s)
      Park SY, Kim HS, Konishi, N.
    • Journal Title

      EMBO J

      Volume: 29 Pages: 3787-3796

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variations in health-related quality of life in Japanese men who underwent iodine-125 permanent brachytherapy for localized prostate cancer2010

    • Author(s)
      Tanaka, N., Fujimoto, K., Asakawa, I., Hirayama, A., Yoneda, T., Yoshida, K., Hirao, Y., Hasegawa M., Konishi, N
    • Journal Title

      Brachytherapy

      Volume: 9 Pages: 300-306

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma2010

    • Author(s)
      Shimada, K, Konishi, N., et al
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 155-160

    • NAID

      10027199949

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 前立腺の良性腺管、前癌病変および癌に浸潤する炎症細胞の免疫組織化学的解析2012

    • Author(s)
      藤井智美、島田啓司、井筒千賀、田中宣道、藤本清秀、平尾和也、小西 登
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺炎に関わる炎症細胞の免疫組織化学的解析2012

    • Author(s)
      藤井智美, 島田啓司, 中谷公彦, 小西 登
    • Organizer
      第101回病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-27
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 前立腺癌小線源治療後の排尿障害に対するα-1 ブロッカーの硬化-ナフトピジル・シロドシン対照試験2012

    • Author(s)
      田中宣道, 堀 俊太, 森澤洋介, 篠原雅岳, 喜馬啓介, 穴井 智, 鳥本一匡, 平山暁秀, 藤本清秀, 浅川勇雄, 長谷川正俊, 小西 登, 平尾佳彦
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺疾患の発生・進展における間質リモデリングの役割2012

    • Author(s)
      穴井 智、井上剛志、三宅牧人、池田朋博、松村善昭、田中宣道、平尾佳彦、島田啓司、小西 登、藤本清秀
    • Organizer
      第28回前立腺シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 年齢・体積別生検本数ノモグラムを用いた前立腺生検における至適生検本数の検討2012

    • Author(s)
      田中宣道、飯田孝太、大西健太、橋村正哉、辰巳佳弘、桑田真臣、穴井 智、松村善昭、山本雅司、 島田啓司、 小西 登、平尾佳彦、藤本清秀
    • Organizer
      第28回前立腺シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 前癌病変および癌に浸潤する炎症細胞の免疫組織化学的解析2012

    • Author(s)
      藤井智美、島田啓司、井筒千賀、田中宣道、藤本清秀、平尾和也、小西 登
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 前立腺癌小線源治療後の排尿障害に対するα-1ブロッカーの硬化-ナフトピジル・シロドシン対照試験2012

    • Author(s)
      田中宣道, 堀 俊太, 森澤洋介, 篠原雅岳, 喜馬啓介, 穴井 智, 鳥本一匡, 平山暁秀, 藤本清秀, 浅川勇雄, 長谷川正俊, 小西 登,平尾佳彦
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 植村天受、PTEN 遺伝子改変マウスを用いた酢酸クロルマジノンによる前立腺癌発癌抑制効果2011

    • Author(s)
      小池浩之, デベラスコ マルコ, 山本 豊, 畑中祐二, ワン イー, 島田啓司, 吉川和宏, 荒尾徳三, 西尾和人, 小西 登
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-23
    • Related Report
      2012 Final Research Report
  • [Presentation] PTEN遺伝子改変マウスを用いた酢酸クロルマジノンによる前立腺癌発癌抑制効果2011

    • Author(s)
      小池浩之, 島田啓司, 小西登, 植村天受, 他
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] CD138(Syndecan-1)を介した前立腺癌進展メカニズムの解析2011

    • Author(s)
      島田啓司、藤井智美、穴井智、藤本清秀、平尾佳彦、小西登
    • Organizer
      第27回前立腺シンポジウム
    • Place of Presentation
      東京コンファレンスセンター(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前立腺癌初期 staging における骨シンチの有用性2010

    • Author(s)
      田中宣道,大塚憲司, 富岡厚志,穴井 智,三宅牧人, 井上剛志, 池田朋博,松村善昭,山本雅司, 藤本清秀,平尾佳彦, 小西 登
    • Organizer
      第26回前立腺シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 放射線抵抗性前立腺癌に対する分子標的治療の試み2010

    • Author(s)
      穴井 智,井上剛志, 池田朋博,三宅牧人, 千原良友, 田中宣道,藤本清秀,平尾佳彦,島田啓司,小西 登
    • Organizer
      第26回前立腺シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel signal associated with reactive oxygen species for maintenance of prostate cancer stem cell-like population2010

    • Author(s)
      Shimada, K., Anai, S., Fujimoto, K., Hirao, Y., Tasaki, M., Konishi, N
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Pre-clinical chemopreventive efficacy of chlormadinone acetate against prostate cancer2010

    • Author(s)
      Koike, H., Marco A. De Velasco, Shimada, K., Yoshikawa, K., Arao, T., Nishio, K., Konishi, N., Uemura, H
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] The phosphorylation status of FADD in biopsy specimens is associated with biochemical recurrence after prostatectomy2010

    • Author(s)
      Marco A. De Velasco, Koike, H., Shimada, K., Yoshikawa, K., Konishi, N., Arao, T., Nishio, K., Uemura, H
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Gleason 分類とハイリスク前立腺癌2010

    • Author(s)
      小西 登, 島田啓司, 池田朋博, 田中宣道
    • Organizer
      第37回尿路悪性腫瘍研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] CD138 を介したホルモン不応性前立腺癌進展メカニズムの解析と病理学的意義について2010

    • Author(s)
      島田啓司,Marco A. De Velasco, 植村天受,田崎正人,小西 登
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺全摘標本における Molecular Profileによる再発予測2010

    • Author(s)
      穴井 智,井上剛志, 三宅牧人,池田朋博,富岡厚志,桑田真臣,松村善昭,谷 善啓,田中宣道,藤本清秀,平尾佳彦,島田啓司,小西 登
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-27
    • Related Report
      2012 Final Research Report
  • [Book] 最新医学 第67巻/第3号 特集 がんの分子病理診断 -免疫染色と遺伝子診断の進歩-2012

    • Author(s)
      小西 登、島田啓司
    • Publisher
      最新医学社
    • Related Report
      2012 Final Research Report
  • [Book] 最新医学 第67巻/第3号 特集 がんの分子病理診断 -免疫染色と遺伝子診断の進歩-2012

    • Author(s)
      小西 登、島田啓司
    • Publisher
      最新医学社
    • Related Report
      2012 Annual Research Report
  • [Book] 病理と臨床(第28巻、12章 男性生殖器、神経周囲浸潤)2010

    • Author(s)
      小西登
    • Total Pages
      2
    • Publisher
      文光堂
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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