| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
NACC1 is a member of pluripotent transcription factor, and associates with malignant phenotypes of tumor cells. The present study investigated the molecular mechanisms of NACC1 in malignant tumors. We represented that NACC1 directly bound to HDAC6, and deacetylated tubulin and cortactin. This deacetylation introduced acceleration of motility and invasion of tumor cells. NACC1 also contributed to stabilization of ERBB2 protein expression through the deacetylation of HSP90. The SUMOlylation of NACC1 introduced the binding with PML protein. Our study demonstrated that overexpression of NACC1 protein contributes to motility, invasion, proliferation activities of tumor cells, and may be a good candidate for molecular target medicine in cancer therapy.
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