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Identification and analysis of regulatory sRNAs involved inthe pathogenicity of gas-gangrene related bacteria

Research Project

Project/Area Number 22390081
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionKanazawa University

Principal Investigator

SHIMIZU Tohru  金沢大学, 医学系, 教授 (80235655)

Co-Investigator(Renkei-kenkyūsha) OHTANI Kaori  金沢大学, 医学系, 講師 (30377410)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsウェルシュ菌 / 調節RNA分子 / ガス壊疽 / 食中毒 / 芽胞(胞子) / 転写調節RNA / ウェルシュ菌食中毒 / 芽胞 / 病原性 / 遺伝子発現調節 / 調節RNA / 遺伝子発現調
Research Abstract

Clostridium perfringens is a causative agent for gas gangrene and controls toxin production via complex regulatory networks. In this study, we identified many novel sRNAs in C. perfringens and showed that some of the sRNAs are also regulated by a major regulatory system for toxin production. Furthermore, we found that one of the sRNAs, virX is involved in the regulation of spore formation which turns into production of enterotoxin for food poisoning.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (5 results)

  • [Journal Article] Unique regulatory mechanism of sporulation and enterotoxin production in Clostridium perfringens2013

    • Author(s)
      Ohtani, K.
    • Journal Title

      Journal of Bacteriology

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complex transcriptional regulation of citrate metabolism in Clostridium perfringens2012

    • Author(s)
      Yuan, Y., Ohtani, K., Yoshizawa, S., Shimizu, T
    • Journal Title

      Anaerobe

      Volume: 18 Issue: 1 Pages: 48-54

    • DOI

      10.1016/j.anaerobe.2011.09.004

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global regulation of gene expression in response to cysteine availability in Clostridium perfringens2010

    • Author(s)
      Andre, G., Haudecoeur, E., Monot, M., Ohtani, K., Shimizu, T.,(他)
    • Journal Title

      BMC Microbiol

      Volume: 10 Issue: 1 Pages: 234-234

    • DOI

      10.1186/1471-2180-10-234

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a two-component VirR/Vir S regulon in Clostridium perfringens2010

    • Author(s)
      Ohtani, K., Hirakawa, H., Tashiro, K., Yoshizawa, S., Kuhara, S., Shimizu, T
    • Journal Title

      Anaerobe

      Volume: 16 Issue: 3 Pages: 258-264

    • DOI

      10.1016/j.anaerobe.2009.10.003

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a two-component VirR/VirS regulon in Clostridium perfringens2010

    • Author(s)
      Ohtani, et.al.
    • Journal Title

      Anaerobe

      Volume: 16 Pages: 258-264

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global regulation of gene expression in response to cysteine availability in Clostridium perfrineens2010

    • Author(s)
      Andre, et. al.
    • Journal Title

      BMC Microbiol

      Volume: 10 Pages: 234-240

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique regulatory mechanism of sporulation and enterotoxin production in Clostridium perfringens

    • Author(s)
      Ohtani, K., Hirakawa, H., Paredes-Sabja, D., Tashiro, K., Kuhara, S., Sarker, M., Shimizu, T
    • Journal Title

      J. Bacteriol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Novel regulatory mechanism for spore formation and enterotoxin production in Clostridium perfringens2013

    • Author(s)
      大谷 郁, Huyen Hoang, 清水 徹
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県)
    • Year and Date
      2013-03-18
    • Related Report
      2012 Final Research Report
  • [Presentation] ウェルシュ菌における芽胞形成およびエンテロトキシン産生調節機構の解析2013

    • Author(s)
      大谷 郁
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      千葉県千葉市幕張メッセ国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Subtilase cytotoxinはPERK依存的経路を介してストレス顆粒の形成を誘導する2013

    • Author(s)
      津々木博康
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      千葉県千葉市幕張メッセ国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel regulatory mechanism for spore formation and enterotoxin production in Clostridium perfringens2011

    • Author(s)
      Ohtani, K, et al.
    • Organizer
      7th International Conference of the Molecular Biology and Pathogenesis of the Clostridia
    • Place of Presentation
      アメリカ・アイオワ大学(招待講演)
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nove; regulatory mechanism for sopre formation and enterotoxin production in Clostridium perfringens2011

    • Author(s)
      Ohtani, K., Hirakawa, H., Paredes-Sabja, D., Tashiro, K., Kuhara, S., Sarker, M., Shimizu, T
    • Organizer
      7th International Conference on the Molecular Biology and Pathogenesis o the Clostridia
    • Place of Presentation
      Iowa State Center (Ames, Iowa, USA)
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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