| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
Based on the gene expression analyses, we focused on thechemokine receptor CXCR3 and revealed that CXCR3 regulates the localization of CD8+ T cells within lymphoid tissues early after activation, which affects the formation of memoryCD8+ T cells. Memory CD8+ T cells up-regulated the expression of chemokine and cytokinegenes characteristic of CTLs, whereas down-regulated expression of ribosomal proteingenes associated with cell senescence. Furthermore, we found that 2nd memory up-regulated the NK cell specific genes as compared to 1st memory. Thus we would like to propose that these molecules might be a marker of senescent memory CTLs.
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