| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Research Abstract |
Elucidation of molecular mechanisms for development and maintenance of memory B cells is important for development of efficient vaccination and protective immunity. During immune responses, B cells that bind antigens with a high affinity are selected in the germinal centers of peripheral lymphoid tissues, develop into memory B cells, and maintained for a long time, mechanisms for which have largely been unknown. In this study, we utilized the induced germinal center B (iGB) cell culture system, and identified candidates for the factors involved in the development and maintenance of memory B cells.
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