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Molecular mechanisms for affinity-based selection, development and maintenance of memory B cells.

Research Project

Project/Area Number 22390097
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionTokyo University of Science

Principal Investigator

KITAMURA Daisuke  東京理科大学, 生命医科学研究所, 教授 (70204914)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
KeywordsB 細胞 / 免疫応答 / 免疫学的記憶 / 胚中心 / 親和性成熟 / 免疫学 / B細胞 / 記憶B細胞 / 細胞分化 / 胚中印
Research Abstract

Elucidation of molecular mechanisms for development and maintenance of memory B cells is important for development of efficient vaccination and protective immunity. During immune responses, B cells that bind antigens with a high affinity are selected in the germinal centers of peripheral lymphoid tissues, develop into memory B cells, and maintained for a long time, mechanisms for which have largely been unknown. In this study, we utilized the induced germinal center B (iGB) cell culture system, and identified candidates for the factors involved in the development and maintenance of memory B cells.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (31 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (13 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Identification of CMTM7 as a Transmembrane Linker of BLNK and the B-cell Receptor2012

    • Author(s)
      北村大介, 宮崎敦子, 典後沢里美, 他
    • Journal Title

      PLoS One

      Volume: 7 Issue: 2 Pages: e31829-e31829

    • DOI

      10.1371/journal.pone.0031829

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosomal-associated protein transmembrane 5.2012

    • Author(s)
      Yohei Kawano
    • Journal Title

      Molecular and Cellular Biology

      Volume: 32 Issue: 21 Pages: 4462-4471

    • DOI

      10.1128/mcb.00531-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.2012

    • Author(s)
      Shinya Hidano
    • Journal Title

      International Immunology

      Volume: 24 Issue: 11 Pages: 719-727

    • DOI

      10.1093/intimm/dxs072

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis.2012

    • Author(s)
      Naoko Ozaki
    • Journal Title

      International Immunology

      Volume: 24 Issue: 9 Pages: 539-550

    • DOI

      10.1093/intimm/dxs078

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin | locus.2012

    • Author(s)
      Sakamoto, S., ffakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Miyazaki, K., Romanow, W. J., Ikawa, T., Kitamura, D., Yanagihira, I., Minato, N., Murre, C., Agata, Y
    • Journal Title

      J. Immunol

      Volume: 188 Issue: 11 Pages: 5547-5560

    • DOI

      10.4049/jimmunol.1002346

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-vitro derived germinal centre B ceils differentially generate memory B or plasma cells in vivo2011

    • Author(s)
      北村大介, 野嶋卓也, 羽生田圭, 他
    • Journal Title

      Nature Communications

      Volume: 2 Issue: 1 Pages: 465-465

    • DOI

      10.1038/ncomms1475

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tolerance induction of IgG+memory B cells by T-cell independent type II antigens.2011

    • Author(s)
      Haniuda, K., Nojima, T., Ohyama, K. and Kitamura, D.
    • Journal Title

      J. Immunol.

      Volume: 186 Pages: 5620-5628

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tolerance induction of IgG+ memory B cells by T-cell independent type II antigens2011

    • Author(s)
      北村大介, 羽生田圭, 野嶋卓也, 大山亨介
    • Journal Title

      The Journal of Immunology

      Volume: 186 Pages: 5620-5628

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HS1 has a central role in the trafficking and homing of leukemic B cells.2010

    • Author(s)
      Scielzo, C.
    • Journal Title

      Blood

      Volume: 116 Pages: 3537-3546

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3.2010

    • Author(s)
      Kim, B.-H.
    • Journal Title

      Mol.Cancer

      Volume: 9 Pages: 36-36

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プレB細胞レセプターシグナルによるL鎖遺伝子再構成の誘導機構2010

    • Author(s)
      北村大介
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 1-8

    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulatory mechanisms for memory B cell development and function.2013

    • Author(s)
      Daisuke Kitamura
    • Organizer
      The 1st Symposium of International Immunological Memory and Vaccine Forum.
    • Place of Presentation
      東京
    • Year and Date
      2013-01-29
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel regulatory mechanism for T-dependent immune responses through gp49B.2012

    • Author(s)
      Saori Fukao, Kei Haniuda, Toshiyuki Takai, Daisuke Kitamura
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 誘導性胚中心B細胞を用いた免疫応答機構の解明とその応用2012

    • Author(s)
      北村大介
    • Organizer
      筑波大学・東京理科大学生命医科学研究所合同シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-10-19
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] B細胞免疫応答のin vitro解析とその臨床応用の可能性2012

    • Author(s)
      北村大介
    • Organizer
      Renal Transplantation Forum 2012
    • Place of Presentation
      東京
    • Year and Date
      2012-09-01
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] gp49B regulates antibody production from marginal zone and memory B cells in the immune responses.2011

    • Author(s)
      Saori Fukao, Kei Haniuda, Toshiyuki Takai, Daisuke Kitamura
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] gp49B regulates antibody production from margmal zone and memory B cells in the immune responses2011

    • Author(s)
      北村大介, 深尾紗央里, 羽生田生, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] B-cell memory generation in induced germinal center B cells.2010

    • Author(s)
      北村大介
    • Organizer
      The 2nd Synthetic Immunology Workshop.
    • Place of Presentation
      京都
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] B-cell memory generation in induced germinal center B cells2010

    • Author(s)
      Daisuke Kitamura
    • Organizer
      The 2nd Synthetic Immunology Workshop.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] The germinal center-like B cell culture system revealed that IL-21 reversibly inhibits memory-B-cell generation in vitro.2010

    • Author(s)
      Takuya Nojima, Kei Haniuda, Tatsuya Moutai, Ikuo Shiratori, Daisuke Kitamura
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Year and Date
      2010-08-26
    • Related Report
      2012 Final Research Report
  • [Presentation] T-cell dependent IgG1 B-cell memory is not activated, but tolerized, on binding eith T-cell independent type II antigen.2010

    • Author(s)
      Kei Haniuda, Takuya Nojima, Daisuke Kitamura
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Year and Date
      2010-08-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of the novel transmembrane protein CMTM7 in BCR signal transduction and endocytosis.2010

    • Author(s)
      Atsuko Miyazaki, Satomi Yogosawa, Daisuke Kitamura
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Year and Date
      2010-08-23
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel regulatory mechanism for T-dependent immune responses through gp49B.

    • Author(s)
      深尾紗央里
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulatory mechanisms for memory B cell development and function.

    • Author(s)
      北村大介
    • Organizer
      The 1st Symposium of International Immunological Memory and Vaccine Forum.
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] 岩波生物学辞典 第5版2013

    • Author(s)
      北村大介(分担)
    • Total Pages
      2192
    • Publisher
      岩波書店
    • Related Report
      2012 Annual Research Report
  • [Book] 分子細胞生物学事典2013

    • Author(s)
      北村大介(分担)
    • Total Pages
      580
    • Publisher
      医学評論社
    • Related Report
      2012 Annual Research Report
  • [Book] II 型 T細胞非依存性抗原による記憶 B 細胞の自己寛容誘導.臨床免疫・アレルギー科2012

    • Author(s)
      羽生田圭、北村大介
    • Publisher
      科学評論社
    • Related Report
      2012 Final Research Report
  • [Book] 生物学辞典2010

    • Author(s)
      石川統
    • Total Pages
      1634
    • Publisher
      東京化学同人
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.rs.noda.tus.ac.jp/~ribsjm/kitamuralab/indexj.html

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 抗原特異的 B 細胞集団の製造方法2010

    • Inventor(s)
      北村大介
    • Industrial Property Rights Holder
      東京理科大学
    • Filing Date
      2010-10-25
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗原特異的B細胞集団の製造方法2010

    • Inventor(s)
      北村大介
    • Industrial Property Rights Holder
      東京理科大学
    • Filing Date
      2010-10-25
    • Related Report
      2011 Annual Research Report
    • Overseas

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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