• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Drug development targeting for regeneration of neurovascular units in neurodegenerative disorders

Research Project

Project/Area Number 22390109
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionTohoku University

Principal Investigator

FUKUNAGA Kohji  東北大学, 大学院・薬学研究科, 教授 (90136721)

Co-Investigator(Kenkyū-buntansha) IWABUCHI Yoshiharu  東北大学, 大学院・薬学研究科, 教授 (20211766)
ITO Yoshihisa  日本大学, 薬学部, 教授 (50151551)
MORIGUCHI Shigaki  東北大学, 大学院・薬学研究科, 講師 (70374949)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords薬物治療学 / ST101 / T型カルシウムチャネル / アルツハイマー病治療薬 / アミロイド前駆タンパク質 / 神経血管ユニット / 神経変性疾患 / 血管再生 / 神経再生 / CaMKII / バナジウム有機錯体 / 心肥大 / ジストロフィン / eNOS / カルモデュリン
Research Abstract

ST101 stimulates memory molecule, Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the hippocampus. In the present study, we investigated whether chronic administration of the neurovascular regenerative compound, ST101 elicits long lasting ameliorating effects on brain functions and defined the molecular mechanism underlying their therapeutic effects in the neurodegenerative disorders. ST101 was now under investigation in Phase II clinical trial of U.S.A. We defined T type voltage-gated calcium channel as molecular target of ST101. We next introduced novel and potent derivative, SAK3 by using neuro2A cells overexpressing T type voltage-gated calcium channel. This is the first discovery of activators of T type voltage-gated calcium channel in the world. The most promising evidence in our studies is that T type calcium channel is novel therapeutic target of Alzheimer therapy to restore the neural networks in the neurodegenerative disorders.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (230 results)

All 2013 2012 2011 2010 Other

All Journal Article (110 results) (of which Peer Reviewed: 109 results) Presentation (118 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Stimulation of σ(1)-receptor restores abnormal mitochondrial Ca(2+) mobilization and ATP production following cardiac hypertrophy.2013

    • Author(s)
      Hideaki Tagashira
    • Journal Title

      Biochimica et Biophysica Acta- General Subjects

      Volume: 1830(4) Issue: 4 Pages: 3082-3094

    • DOI

      10.1016/j.bbagen.2012.12.029

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on socioemotional behaviors in offspring rats.2013

    • Author(s)
      Nguyen AT, Nishijo M, Hori E, Nguyen NM, Pham TT, Fukunaga K, Nakagawa H, Tran AH, Nishijo H.
    • Journal Title

      Environ Health Insights

      Volume: 7 Pages: 1-14

    • DOI

      10.4137/ehi.s10346

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus.2013

    • Author(s)
      Liao MH, Xiang YC, Huang JY, Tao RR, Tian Y, Ye WF, Zhang GS, Lu YM, Ahmed MM, Liu ZR, Fukunaga K, Han F.
    • Journal Title

      CNS Neurosci Ther.

      Volume: - Issue: 5 Pages: 329-36

    • DOI

      10.1111/cns.12084

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation.2013

    • Author(s)
      Yamamoto Y, Shioda N, Han F, Moriguchi S, Fukunaga K.
    • Journal Title

      J Pharmacol Sci.

      Volume: 121(3) Pages: 212-226

    • NAID

      10031165466

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial interactions between selective serotonin uptake inhibitors and sigma-1 receptor in heart failure.2013

    • Author(s)
      Bhuiyan S, Tagashira H, Fukunaga K.
    • Journal Title

      J Pharmacol Sci.

      Volume: 121(3) Pages: 177-184

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice.2013

    • Author(s)
      Moriguchi S, Tanaka T, Tagashira H, Narahashi T, Fukunaga K.
    • Journal Title

      Behav Brain Res.

      Volume: 242 Pages: 150-157

    • DOI

      10.1016/j.bbr.2012.12.054

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The γ-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia.2013

    • Author(s)
      Zhang GS, Tian Y, Huang JY, Tao RR, Liao MH, Lu YM, Ye WF, Wang R, Fukunaga K, Lou YJ, Han F.
    • Journal Title

      CNS Neurosci Ther.

      Volume: 19(1) Issue: 1 Pages: 53-60

    • DOI

      10.1111/cns.12032

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tao RR, Huang JY, Shao XJ, Ye WF, Tian Y, Liao MH, Fukunaga K, Lou YJ, Han F, Lu YM. Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin.2013

    • Author(s)
      Tao RR, Huang JY, Shao XJ, Ye WF, Tian Y, Liao MH, Fukunaga K, Lou YJ, Han F, Lu YM.
    • Journal Title

      J Pineal Res.

      Volume: 54(3) Issue: 3 Pages: 271-281

    • DOI

      10.1111/jpi.12009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites2012

    • Author(s)
      Shinoda Y, Fujita K, Saito S, Matsui H, Kanto Y, Nagaura Y, Fukunaga K, Tamura S, Kobayashi T
    • Journal Title

      FEBS Lett

      Volume: 586(19) Pages: 3024-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] P2X(7) signaling promotes microsphere embolism-triggered microglia activation bymaintaining elevation of Fas ligand2012

    • Author(s)
      Lu YM, Tao RR, Huang JY, Li LT, Liao MH, Li XM, Fukunaga K, Hong ZH, Han F
    • Journal Title

      J Neuroinflammation

      Volume: 9 Issue: 1 Pages: 172-172

    • DOI

      10.1186/1742-2094-9-172

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a truncated form of the endoplasmic reticulum chaperone protein, sigma-1 receptor, promotes mitochondrial energy depletion and apoptosis.2012

    • Author(s)
      Norifumi Shioda
    • Journal Title

      J Biol Chem.

      Volume: 287(28) Issue: 28 Pages: 23318-23331

    • DOI

      10.1074/jbc.m112.349142

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The T-type voltage-gated calcium channel as a molecular target of the novel cognitive enhancer ST101 : Enhancement of long-term potentiation and CaMKll autophosphorylation in rat cortical slices.2012

    • Author(s)
      Shigeki Moriguchi
    • Journal Title

      J Neurochem.

      Volume: 121(1) Issue: 1 Pages: 44-53

    • DOI

      10.1111/j.1471-4159.2012.07667.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice2012

    • Author(s)
      Moriguchi S, Yabuki Y, Fukunaga K
    • Journal Title

      J Neurochem

      Volume: 120(4) Issue: 4 Pages: 541-51

    • DOI

      10.1111/j.1471-4159.2011.07608.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant hippocampal spine morphology and impaired memory formation in neuronal platelet-derived growth factor beta-receptor lacking mice.2012

    • Author(s)
      Shioda N, Moriguchi S, Oya T, Ishii T, Shen J, Matsushima T, Nishijo H, Sasahara M, Fukunaga K.
    • Journal Title

      Hippocampus

      Volume: 22(6) Issue: 6 Pages: 1371-1378

    • DOI

      10.1002/hipo.20973

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel dopamine D2 receptor signaling through proteins interacting with the third cytoplasmic loop2012

    • Author(s)
      Fukunaga K, Shioda N
    • Journal Title

      Mol Neurobiol

      Volume: 45(1) Pages: 144-52

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effect of fluvoxamine, sigma-1 receptor high affinity agonist2012

    • Author(s)
      Tagashira H, Fukunaga K
    • Journal Title

      Yakugaku Zasshi

      Volume: 132(2) Pages: 167-72

    • NAID

      130001872003

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal dendritic spine morphology and its signal transduction mechanisms in mental retardation2012

    • Author(s)
      Shioda N, Fukunaga K
    • Journal Title

      Seikagaku

      Volume: 83(12) Pages: 1113-7

    • NAID

      10030345941

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Benefit of vanadium compound in therapy for cardiovascular diseases2012

    • Author(s)
      Fukunaga K
    • Journal Title

      Yakugaku Zasshi

      Volume: 132(3) Pages: 279-84

    • NAID

      130001872021

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites.2012

    • Author(s)
      Shinoda Y, Fujita K, Saito S, Matsui H, Kanto Y, Nagaura Y, Fukunaga K, Tamura S, Kobayashi T.
    • Journal Title

      FEBS Lett.

      Volume: 586(19) Pages: 3024-3029

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benefit of vanadium compound in therapy for cardiovascular diseases.2012

    • Author(s)
      Fukunaga K.
    • Journal Title

      Yakugaku Zasshi.

      Volume: 132(3) Pages: 279-284

    • NAID

      130001872021

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effect of fluvoxamine, sigma-1 receptor high affinity agonist.2012

    • Author(s)
      Tagashira H, Fukunaga K.
    • Journal Title

      Yakugaku Zasshi.

      Volume: 132(2) Pages: 167-172

    • NAID

      130001872003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The T-type voltage-gated calcium channel as a molecular target of the novel cognitive enhancer ST101 : enhancement of long-term potentiation and CaMKII autophosphorylation in rat cortical slices2012

    • Author(s)
      Moriguchi S, Shioda N, Yamamoto Y, Tagashira H, Fukunaga K
    • Journal Title

      J Neurochem.

      Volume: 121 Pages: 44-53

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice2012

    • Author(s)
      Moriguchi S, Yabuki Y, Fukunaga K
    • Journal Title

      J.Neurochem.

      Volume: 120 Pages: 541-551

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel dopamine D2 receptor signaling through proteins interacting with the third cytoplasmic loop2012

    • Author(s)
      Fukunaga K, Shioda N
    • Journal Title

      Mol Neurobiol.

      Volume: 45 Pages: 144-152

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benefit of vanadium compound in therapy for cardiovascular diseases2012

    • Author(s)
      Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 132 Pages: 279-284

    • NAID

      130001872021

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effect of fluvoxamine, sigma-1 receptor high affinity agonist2012

    • Author(s)
      Tagashira H, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 132 Pages: 167-172

    • NAID

      130001872003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The establishment of "evidence based medicine" for the treatment of cerebral stroke-bridgingbasic and clinical sciences-2011

    • Author(s)
      Tokuyama S, Fukunaga K
    • Journal Title

      YakugakuZasshi

      Volume: 131 Pages: 503-504

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Dopaminergic Neuronal Activity by Heart-type Fatty Acid Binding Protein in the Brain2011

    • Author(s)
      Yamamoto Y, Shioda N, Owada Y, Fukunaga K
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 497-501

    • NAID

      130000678828

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior2011

    • Author(s)
      Shioda N, Yamamoto Y, Han F, Moriguchi S, Fukunaga K
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 505-511

    • NAID

      130000678830

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional roles of constitutively active calcineurin in delayed neuronal death after brain ischemia2011

    • Author(s)
      Shioda N, Fukunaga K
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 13-20

    • NAID

      130000451520

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine D2 receptor as a novel target molecule for heart-type fatty acid binding protein2011

    • Author(s)
      Shioda N, Yamamoto Y, Owada Y, Fukunaga K
    • Journal Title

      Nihon Shinkei Seishin Yakurigaku Zasshi

      Volume: 31(3) Pages: 125-30

    • NAID

      10029094334

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotection2011

    • Author(s)
      Bhuiyan MS, Fukunaga K
    • Journal Title

      Expert Opin Ther Targets

      Volume: 15 Pages: 145-155

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drug development targeting for tyrosine phosphatase2011

    • Author(s)
      Fukunaga K
    • Journal Title

      Cell Tecnology

      Volume: 30 Pages: 631-636

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological study on Alzheimer's drugs targeting for calcium/calmodulin-dependent protein kinase II2011

    • Author(s)
      Moriguchi S
    • Journal Title

      J. Pharmacol. Sci

      Volume: 117 Pages: 6-11

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain2011

    • Author(s)
      Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K
    • Journal Title

      J Neurosci

      Volume: 31 Pages: 346-358

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca(2+)/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy2011

    • Author(s)
      Moriguchi S, Oomura Y, Shioda N, Han F, Hori N, Aou S, Fukunaga K
    • Journal Title

      Mol Cell Neurosci

      Volume: 46 Pages: 101-107

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells2011

    • Author(s)
      Han F, Tao RR, Zhang GS, Lu YM, Liu LL, Chen YX, Lou YJ, Fukunaga K, Hong ZH
    • Journal Title

      J Pineal Res

      Volume: 50 Pages: 281-291

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells2011

    • Author(s)
      Han F, Chen YX, Lu YM, Huang JY, Zhang GS, Tao RR, Ji YL, Liao MH, Fukunaga K, Qin ZH
    • Journal Title

      J Pineal Res

      Volume: 51(1) Issue: 1 Pages: 124-35

    • DOI

      10.1111/j.1600-079x.2011.00869.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice2011

    • Author(s)
      Moriguchi S, Yamamoto Y, Ikuno T, Fukunaga K
    • Journal Title

      J Neurochem

      Volume: 117(5) Issue: 5 Pages: 879-91

    • DOI

      10.1111/j.1471-4159.2011.07256.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct cardioprotective effects of 17beta-estradiol and dehydroepiandrosterone on pressure overload-induced hypertrophy in ovariectomized female rats2011

    • Author(s)
      Tagashira H, Bhuiyan MS, Shioda N, Fukunaga K
    • Journal Title

      Menopause

      Volume: 18(12) Pages: 1317-26

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice2011

    • Author(s)
      Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
    • Journal Title

      Hippocampus

      Volume: 21 Pages: 678-687

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation2011

    • Author(s)
      Oyagi A, Moriguchi S, Nitta A, Murata K, Oida Y, Tsuruma K, Shimazawa M, Fukunaga K, Hara H
    • Journal Title

      Brain Res

      Volume: 1419 Pages: 97-104

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CaMK IIδB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart2011

    • Author(s)
      Lu YM, Huang J, Shioda N, Fukunaga K, Shirasaki Y, Li XM, Han F
    • Journal Title

      PLos One

      Volume: 6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting nitrosative stress for neurovascular protection: new implications in brain diseases2011

    • Author(s)
      Tao RR, Ji YL, Lu YM, Fukunaga K, Han F
    • Journal Title

      Curr Drug Targets

      Volume: 13(2) Pages: 272-84

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting nitrosative stress for neurovascular protection : New implications in brain diseases2011

    • Author(s)
      Tao RR, Ji YL, Lu YM, Fukunaga K, Han F
    • Journal Title

      Curr.Drug Targets.

      Volume: 13 Pages: 272-284

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation2011

    • Author(s)
      Oyagi A, Moriguchi S, Nitta A, Murata K, Oida Y, Tsuruma K, Shimazawa M, Fukunaga K, Hara H
    • Journal Title

      Brain Res.

      Volume: 24 Pages: 97-104

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CaMKIIδB Mediates Aberrant NCX1 Expression and the Imbalance of NCX1/SERCA in Transverse Aortic Constriction-Induced Failing Heart2011

    • Author(s)
      Lu YM, Huang J, Shioda N, Fukunaga K, Shirasaki Y, Li XM, Han F
    • Journal Title

      PLoS One.

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct cardioprotective effects of 17β-estradiol and dehydroepiandrosterone on pressure overload-induced hypertrophy in ovariectomized female rats2011

    • Author(s)
      Tagashira H, Bhuiyan S, Shioda N, Fukunaga K
    • Journal Title

      Menopause.

      Volume: 18 Pages: 1317-1326

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice2011

    • Author(s)
      Moriguchi S, Yamamoto Y, Ikuno T, Fukunaga K
    • Journal Title

      J.Neurochem.

      Volume: 117 Pages: 879-891

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells2011

    • Author(s)
      Han F, Chen YX, Lu YM, Huang JY, Zhang GS, Tao RR, Ji YL, Liao MH, Fukunaga K, Qin ZH
    • Journal Title

      J.Pineal.Res.

      Volume: 51 Pages: 124-135

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain2011

    • Author(s)
      Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K
    • Journal Title

      J.Neurosci.

      Volume: 31 Pages: 346-358

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding2011

    • Author(s)
      Bhuiyan MS, Tagashira H, Fukunaga K
    • Journal Title

      Eur.J.Pharmacol.

      Volume: 650 Pages: 621-628

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca(2+)/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy2011

    • Author(s)
      Moriguchi S, Oomura Y, Shioda N, Han F, Hori N, Aou S, Fukunaga K
    • Journal Title

      Mol.Cell Neurosci.

      Volume: 46 Pages: 101-107

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin ameliorates ischemic-like injury-evoked nitrosative stress : Involvement of HtrA2/PED pathways in endothelial cells2011

    • Author(s)
      Han F, Tao RR, Zhang GS, Lu YM, Liu LL, Chen YX, Lou YJ, Fukunaga K, Hong ZH
    • Journal Title

      J.Pineal.Res.

      Volume: 50 Pages: 281-291

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal dendritic spine morphology and its signal transduction mechanisms in mental retardation2011

    • Author(s)
      Shioda N, Fukunaga K
    • Journal Title

      Seikagaku

      Volume: 83 Pages: 1113-1117

    • NAID

      10030345941

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine D2 receptor as a novel target molecule for heart-type fatty acid binding protein2011

    • Author(s)
      Shioda N, Yamamoto Y, Owada Y, Fukunaga K
    • Journal Title

      Nihon Shinkei Seishin Yakurigaku Zasshi.

      Volume: 31 Pages: 125-130

    • NAID

      10029094334

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior2011

    • Author(s)
      Shioda N, Yamamoto Y, Han F, Moriguchi S, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 505-511

    • NAID

      130000678830

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of "evidence based medicine" for the treatment of cerebral stroke--bridging basic and clinical sciences2011

    • Author(s)
      Tokuyama S, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 503-504

    • NAID

      130000678829

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of dopaminergic neuronal activity by heart-type fatty acid binding protein in the brain2011

    • Author(s)
      Yamamoto Y, Shioda N, Owada Y, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 497-501

    • NAID

      130000678828

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug Development Targeting for Tyrosine Phosphatase2011

    • Author(s)
      Fukunaga K
    • Journal Title

      Cell Technology

      Volume: 30 Pages: 631-636

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional roles of constitutively active calcineurin in delayed neuronal death after brain ischemia2011

    • Author(s)
      Shioda N, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 13-20

    • NAID

      130000451520

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotection2011

    • Author(s)
      Bhuiyan MS, Fukunaga K
    • Journal Title

      Expert Opin.Ther.Targets.

      Volume: 15 Pages: 145-155

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice.2011

    • Author(s)
      Moriguchi S, Yamamoto Y, Ikuno T, Fukunaga K.
    • Journal Title

      J Neurochem.

      Volume: (未定)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells.2011

    • Author(s)
      Han F, Chen YX, Lu YM, Huang JY, Zhang GS, Tao RR, Ji YL, Liao MH, Fukunaga K, Qin ZH.
    • Journal Title

      J Pineal Res.

      Volume: (未定)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting sigma-1 receptor signaling by endogenous ligands for cardio protection.2011

    • Author(s)
      Bhuiyan MS, Fukunaga K.
    • Journal Title

      Expert Opin Ther Targets.

      Volume: (未定)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin ameliorates ischemic-like injury-evoked nitrosative stress : In volvement of HtrA2/PED pathways in endothelial cells.2011

    • Author(s)
      Han F, Tao RR, Zhang GS, Lu YM, Liu LL, Chen YX, Lou YJ, Fukunaga K, Hong ZH.
    • Journal Title

      J Pineal Res.

      Volume: 50 Pages: 281-291

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding.2011

    • Author(s)
      Bhuiyan MS, Tagashira H, Fukunaga K
    • Journal Title

      Eur J Pharmacol.

      Volume: 650 Pages: 621-628

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) aciivity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.2011

    • Author(s)
      Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K
    • Journal Title

      J Neurosci.

      Volume: 31 Pages: 346-358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting sigma-1 receptor signaling by endogenous ligands for cardio protection.2011

    • Author(s)
      Moriguchi S, Oomura Y, Shioda N, Han F, Hori N, Aou S, Fukunaga K
    • Journal Title

      Mol Cell Neurosci.

      Volume: 46 Pages: 101-107

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [Functional roles of constitutively active calcineurin in delayed neuron al death after brain ischemia].2011

    • Author(s)
      Shioda N, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 13-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior.2011

    • Author(s)
      Shioda N, Yamamoto Y, Han F, Moriguchi S, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 505-511

    • NAID

      130000678830

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Dopaminergic Neuronal Activity by Heart-type Fatty Acid Binding Protein in the Brain.2011

    • Author(s)
      Yamamoto Y, Shioda N, Owada Y, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 497-501

    • NAID

      130000678828

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The establishment of "evidence based medicine" for the treatment of cerebral stroke-bridaine basic and clinical sciences2011

    • Author(s)
      Tokuyama S, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 503-504

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Expression profiling of Ca(2+)/calmodulin-dependent signaling molecues in the rat dorsal and ventral hippocampus after acute lead exposuie.2011

    • Author(s)
      Zhang GS, Ye WF, Tao RR, Lu YM, Shen GF, Fukunaga K, Huang JY, Ji YL, Han F
    • Journal Title

      Exp Toxicol Pathol.

      Volume: (未定)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncouplingaccounts for cytoprotection by3-[2-[4-(3-chloro-2-methylphenyl)-1-piperaz inyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylm ethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice2010

    • Author(s)
      Han F, Lu YM, Hasegawa H, Kanai H, Hachimura E, Shirasaki Y, Fukunaga K
    • Journal Title

      J. Pharmacol. Exp. Ther

      Volume: 332 Pages: 421-428

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice2010

    • Author(s)
      Shioda N, Yamamoto Y, Han F, Moriguchi S, Yamaguchi Y, Hino M, Fukunaga K
    • Journal Title

      J. Pharmacol. Exp. Ther

      Volume: 333 Pages: 43-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative measurement of In Vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE2010

    • Author(s)
      Hosokawa T, Saito T, Asada A, Fukunaga K, Hisanaga SI
    • Journal Title

      Mol. Cell Proteomics

      Volume: 9 Pages: 1133-1143

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heart-type fatty acid binding protein regulates dopamine D2 receptor function in mouse brain2010

    • Author(s)
      Shioda N, Yamamoto Y, Watanabe M, Binas B, Owada Y, Fukunaga K
    • Journal Title

      J Neurosci

      Volume: 30 Pages: 3146-3155

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons2010

    • Author(s)
      Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H
    • Journal Title

      Neurosci. Res

      Volume: 67 Pages: 126-136

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes2010

    • Author(s)
      Lu YM, Shioda N, Yamamoto Y, Han F, Fukunaga K
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1799 Pages: 429-441

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice2010

    • Author(s)
      Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of Sigma-1 receptor by dehydroepiandrosterone ameliorates hypertension-induced kidney hypertrophy in ovariectomized rats2010

    • Author(s)
      Bhuiyan MS, Fukunaga K
    • Journal Title

      Exp BiolMed

      Volume: 235 Pages: 356-364

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dehydroepiandrosterone-Mediated Stimulation of Sigma-1 Receptor Activates Akt-eNOS Signaling in the Thoracic Aorta of Ovariectomized Rats with Abdominal Aortic Banding2010

    • Author(s)
      Bhuiyan MS, Tagashira H, Fukunaga K
    • Journal Title

      Cardiovasc Ther

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function2010

    • Author(s)
      Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Morita SY, Shimazawa M, Fukunaga K, Takeda J, Saito N, Hara H
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions2010

    • Author(s)
      Bhuiyan MS, Tagashira H, Shioda N, Fukunaga K
    • Journal Title

      Expert Opin Ther Targets

      Volume: 14 Pages: 1009-1022

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation with fluvoxamine ameliorates transverse aortic constriction-induced myocardial hypertrophy and dysfunctions in mice2010

    • Author(s)
      Tagashira H, Bhuiyan MS, Shioda N, Hasegawa H, Kanai H, Fukunaga K
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 299

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells2010

    • Author(s)
      Kajihara R, Fukushige S, Shioda N, Tanabe K, Fukunaga K, Inui S
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 401 Pages: 350-355

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of Ca(2+)/calmodulin-dependent signaling molecules in the rat dorsal and ventral hippocampus after acute lead exposure2010

    • Author(s)
      Zhang GS, Ye WF, Tao RR, Lu YM, Shen GF, Fukunaga K, Huang JY, Ji YL, Han F
    • Journal Title

      Exp Toxicol Pathol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of an animal model of postmenopausal cardiac hypertrophy and novel mechanisms responsible for cardiac decompensation using ovariectomized pressure-overloaded rats2010

    • Author(s)
      Bhuiyan MS, Fukunaga K
    • Journal Title

      Menopause

      Volume: 17 Pages: 213-221

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prandial increase of leptin in the brain activates spatial learning and memory2010

    • Author(s)
      Oomura Y, Aou S, Fukunaga K
    • Journal Title

      Pathophysiology

      Volume: 17 Pages: 119-127

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders:Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D(2) and D(3) Receptors2010

    • Author(s)
      Shioda N, Takeuchi Y, Fukunaga K
    • Journal Title

      J Pharmacol Sci

      Volume: 114 Pages: 25-31

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil-induced neuroprotection of acetylcholinergic neurons in olfactory bulbectomized mice2010

    • Author(s)
      Yamamoto Y, Shioda N, Han F, Moriguchi S, Fukunaga K
    • Journal Title

      Yakugaku Zasshi

      Volume: 130 Pages: 717-721

    • NAID

      130000259461

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor causes hippocampal dysfunction in mice.2010

    • Author(s)
      Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
    • Journal Title

      Hippocampus.

      Volume: (未定)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CaMKII phosphorylates serine 10 of p27 and confers apoptosis resista nee to HeLa cells.2010

    • Author(s)
      Kajihara R, Fukushige S, Shioda N, Tanabe K, Fukunaga K, Inui S
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 401 Pages: 350-355

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation with fluvoxamine ameliorates transverse aortic constriction-induced myocardial hypertrophy and dysfunctions in mice.2010

    • Author(s)
      Tagashira H, Bhuiyan MS, Shioda N, Hasegawa H, Kanai H, Fukunaga K
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 299 Pages: 1535-1545

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-over load-induced hynertronhy and dysfunctions.2010

    • Author(s)
      Bhuiyan MS, Tagashira H, Shioda N, Fukunaga K
    • Journal Title

      Expert Opin Ther Targets.

      Volume: 14 Pages: 1009-1022

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKb eta in neurite spine formation, contributing to cognitive function.2010

    • Author(s)
      Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Morita SY, Shimazawa M, Fukunaga K, Takeda J, Saito N, Hara H
    • Journal Title

      PLoS One.

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dehydroepiandrosterone-Mediated Stimulation of Sigma-1 Receptor Activates Akt-eNOS Signaling in the Thoracic Aorta of Ovariectomized Rats with Abdominal Aortic Banding.2010

    • Author(s)
      Bhuiyan MS, Tagashira H, Fukunaga K
    • Journal Title

      Cardiovasc Ther.

      Volume: (未定)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of Sigma-1 receptor by dehydroepiandrosterone ameliorates hynertension-induced kidney hynertronhy in ovariectomized rats.2010

    • Author(s)
      Bhuiyan MS, Fukunaga K
    • Journal Title

      Exp Biol Med.

      Volume: 235 Pages: 356-364

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.2010

    • Author(s)
      Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T
    • Journal Title

      PLoS One.

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes.2010

    • Author(s)
      Lu YM, Shioda N, Yamamoto Y, Han F, Fukunaga K
    • Journal Title

      Biochim.Biophys.Acta.

      Volume: 1799 Pages: 429-441

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons.2010

    • Author(s)
      Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H
    • Journal Title

      Neurosci.Res.

      Volume: 67 Pages: 126-136

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart-type fatty acid binding protein regulates dopamine D2 receptor function in mouse brain.2010

    • Author(s)
      Shioda N, Yamamoto Y, Watanabe M, Binas B, Owada Y, Fukunaga K
    • Journal Title

      J Neurosci.

      Volume: 30 Pages: 3146-3155

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative measurement of In Vivo phosphorylation states of CdkS activator p35 by Phos-tag SDS-PAGE.2010

    • Author(s)
      Hosokawa T, Saito T, Asada A, Fukunaga K, Hisanaga SI
    • Journal Title

      Mol.Cell Proteomics.

      Volume: 9 Pages: 1133-1143

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hip pocampal CA1 region.2010

    • Author(s)
      Moriguchi S, Shioda N, Yamamoto Y, Fukunaga K
    • Journal Title

      Neuroscience.

      Volume: 166 Pages: 1158-1166

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Cognitive Enhancer, ZSET1446/ST10I, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice.2010

    • Author(s)
      Shioda N, Yamamoto Y, Ban F, Moriguchi S, Yamaguchi Y, Hino M, Fukunaga K
    • Journal Title

      J.Pharmacol.Exp.Ther.

      Volume: 333 Pages: 43-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-meth ylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-l-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular by nertroohied Mice.2010

    • Author(s)
      Han F, Lu YM, Hasegawa H, Kanai H, Hachimura E, Shirasaki Y, Fukunaga K
    • Journal Title

      J.Pharmacol.Exp.Ther.

      Volume: 332 Pages: 421-428

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of an animal model of postmenopausal cardiac hypert rophy and novel mechanisms responsible for cardiac decompensation using ovariectomized pressure-overloaded rats.2010

    • Author(s)
      Bhuiyan MS, Fukunaga K
    • Journal Title

      Menopause

      Volume: 17 Pages: 213-221

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders : Proteins Interacting With the Third C ytoplasmic Loop of Dopamine D(2) and D(3) Receptors.2010

    • Author(s)
      Shioda N, Takeuchi Y, Fukunaga K
    • Journal Title

      J Pharmacol Sci.

      Volume: 114 Pages: 25-31

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [Donepezil-induced neuroprotection of acetylcholinergic neurons in olfactory bulbectomized mice]2010

    • Author(s)
      Yamamoto Y, Shioda N, Han F, Moriguchi S, Fukunaga K
    • Journal Title

      Yakugaku Zasshi.

      Volume: 130 Pages: 717-721

    • NAID

      130000259461

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経変性疾患治療におけるsigma-1受容体リガンドの臨床的意義2013

    • Author(s)
      福永浩司
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] ノビレチンはパーキンソン病モデルマウスの認知障害を改善する2013

    • Author(s)
      福永浩司、矢吹悌、大泉康
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 大動脈狭窄モデルにおける選択的 sigma-1 受容体アゴニスト SA4503 の心筋保護作用2013

    • Author(s)
      平野光河、田頭秀章、福永浩司
    • Organizer
      日本薬学会 第132年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経変性疾患治療における sigma-1 受容体リガンドの臨床的意義2013

    • Author(s)
      福永浩司
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海馬歯状回におけるDHEAによるsigma-1受容体の賦活化と抗うつ作用2013

    • Author(s)
      森口茂樹、山本由似、佐々木譲、宮嶋晃輔、田頭秀章、福永浩司
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心筋細胞におけるSigma-1 受容体を介するミトコンドリアATP 産生の制御2013

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] ドパミンD2受容体を介したCaMKIIδ3核内移行制御機構2013

    • Author(s)
      塩田倫史、澤井優広、福永浩司
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 認知機能改善薬 ST101 は統合失調症モデルラットの認知機能を改善する2013

    • Author(s)
      矢吹悌、中川西修、丹野孝一、福永浩司
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス脳虚血におけるL-シトルリン経口投与による脳血管保護作用2013

    • Author(s)
      志賀野美幸、矢吹悌、塩田倫史、熊谷弘太、森田匡彦、福永浩司
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sigma-1受容体の構造と心臓機能2012

    • Author(s)
      福永浩司、田頭秀章、塩田倫史
    • Organizer
      生体機能と創薬シンポジウム2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] The mitochondrial Ca2+ transport and ATP production though sigma-1 receptor in heart2012

    • Author(s)
      Fukunaga K, Tagashira H
    • Organizer
      Basic Cardiovascular Sciences 2012 Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel Alzheimer's therapeutics, ST101 enhances acetylcholine release through T-type voltage-gated calcium channel2012

    • Author(s)
      Fukunaga K, Yamamoto Y and Moriguchi S
    • Organizer
      Alzheimer's Association of International Conference
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経変性疾患におけるニコチン受容体を介するニューロン死の抑制制御2012

    • Author(s)
      福永浩司
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質によるドパミンD2受容体の機能調節2012

    • Author(s)
      福永浩司、塩田倫史
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Drug Development of Novel Cognitive Enhancer for Alzheimer Disease Therapy2012

    • Author(s)
      Fukunaga K
    • Organizer
      New Perspectives in the Neuroscience of Psychiatric and Neurological Disorders
    • Place of Presentation
      Soul, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規アルツハイマー治療候補薬 ST101 による認知機能改善のメカニズム2012

    • Author(s)
      福永浩司、山本由似
    • Organizer
      第42回日本神経精神薬理学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] T型カルシウムチャネル賦活化と認知機能調節2012

    • Author(s)
      森口茂樹、塩田倫史、田頭秀章、福永浩司
    • Organizer
      第42回日本神経精神薬理学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質FABP 欠損マウスにおける不安様行動とシグナル伝達異常2012

    • Author(s)
      山本由似、塩田倫史、大和田裕二、福永浩司
    • Organizer
      第42回日本神経精神薬理学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新生仔期腹側海馬損傷ラットの統合失調症様認知機能障害モデル動物としての有用性2012

    • Author(s)
      矢吹悌、森口茂樹、塩田倫史、中川西修、小野木弘志、丹野孝一、只野武、福永浩司
    • Organizer
      第42回日本神経精神薬理学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経細胞死における新規シグマ-1 受容体スプライスバリアントの機能的役割2012

    • Author(s)
      塩田倫史、福永浩司
    • Organizer
      第39 回 日本脳科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cognitive deficit via imbalance of CaM kinase II and calcineurin activities in Na+/Ca2+ exchanger type-2 knockout mice.2012

    • Author(s)
      Shigeki Moriguchi, Satomi Kita, Issei Komuro. Takahiro Iwamoto and Kohji Fukunaga
    • Organizer
      Neuroscience 2012 第 35 回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロテインホスファターゼ1 は CaMKIIdelta3 の核内移行を制御する2012

    • Author(s)
      塩田倫史、澤井優広、福永浩司
    • Organizer
      Neuroscience 2012 第 35 回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 黒質ドパミン神経細胞におけるプロテインホスファターゼ1によるCaMKIIδ3 核内移行制御機構の解明2012

    • Author(s)
      澤井優広、塩田倫史、福永浩司
    • Organizer
      第11回 次世代を担う若手ファーマ・バイオフォーラム2012
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] NCX2欠損マウスにおける認知機能障害とCaMキナーゼIIおよびカルシニューリンの活性異常2012

    • Author(s)
      森口茂樹、喜多紗斗美、岩本隆宏、福永浩司
    • Organizer
      第14回応用薬理シンポジウム
    • Place of Presentation
      山梨
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sigma-1 受容体の構造と心臓機能2012

    • Author(s)
      福永浩司、田頭秀章、塩田倫史
    • Organizer
      生体機能と創薬シンポジウム 2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] MPTP 誘発性運動機能障害及び認知機能障害に対する nobiletin の改善効果2012

    • Author(s)
      矢吹悌、森口茂樹、塩田倫史、大泉康、福永浩司
    • Organizer
      生体機能と創薬シンポジウム 2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 黒質ドパミン神経変性への脂肪酸結合タンパク質の関与2012

    • Author(s)
      小林由佳、塩田倫史、大和田祐二、福永浩司
    • Organizer
      生体機能と創薬シンポジウム 2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心臓圧負荷モデルにおける高親和性 sigma-1 受容体アゴニストSA4503 の心筋保護作用2012

    • Author(s)
      平野光河、田頭秀章、福永浩司
    • Organizer
      第23回 霧島神経薬理フォーラム
    • Place of Presentation
      熊本
    • Related Report
      2012 Annual Research Report
  • [Presentation] Abnormal fear-related memory via enhancement of CaM kinase II and IV activities in Na+/Ca2+ exchanger type-1 deficit mice.2012

    • Author(s)
      Shigeki Moriguchi, Shun Ishikawa, Satomi Kita, Issei Komuro, Takahiro Iwamoto and Kohji Fukunaga
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sigma-1 receptor agonist ameliorates mitochondrial ATP production and apoptosis in cardiac myocytes.2012

    • Author(s)
      Tagashira H, Shioda N, Bhyuiyan MS, Fukunaga K
    • Organizer
      Basic Cardiovascular Sciences 2012 Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] The mitochondrial Ca2+ transport and ATP production though sigma-1 receptor in heart.2012

    • Author(s)
      Fukunaga K, Tagashira H
    • Organizer
      Basic Cardiovascular Sciences 2012 Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] T-type voltage-gated calcium channel activated by ST101 is a novel molecular target as cognitive enhancer.2012

    • Author(s)
      Shigeki Moriguchi and Kohji Fukunaga
    • Organizer
      Alzheimer’s Association of International Conference
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel Alzheimer’s therapeutics, ST101 enhances acetylcholine release through T-type voltage-gated calcium channel.2012

    • Author(s)
      Kohji Fukunaga, Yui Yamamoto and Shigeki Moriguchi
    • Organizer
      Alzheimer’s Association of International Conference
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心筋障害におけるエストロゲンおよびデヒドロエピアンドロステロンの異なるeNOS 調節機構2012

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      第12回日本NO学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新生仔期腹側海馬(NVH)損傷ラットにおける認知機能障害のメカニズム2012

    • Author(s)
      矢吹悌、森口茂樹、塩田倫史、中川西修、小野木弘志、丹野孝一、只野武、福永浩司
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fluvoxamineはsigma-1受容体を介してミトコンドリアATP産生を促進する2012

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質によるドパミンD2受容体の機能調節2012

    • Author(s)
      福永浩司、塩田倫史
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋小胞体-ミトコンドリアカルシウムシグナルにおけるsigma-1受容体の役割2012

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規アルツハイマー病治療薬候補化合物ST101はT型カルシウムチャネルを活性化して大脳皮質LTPを促進する2012

    • Author(s)
      森口茂樹、塩田倫史、山本由似、田頭秀章、福永浩司
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規シグマ1受容体によるミトコンドリア機能調節と神経細胞死2012

    • Author(s)
      塩田倫史、石川潔、福永浩司
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規アルツハイマー病治療薬候補化合物ST101は海馬内アセチルコリン遊離を促進して認知機能を改善する2012

    • Author(s)
      山本由似、塩田倫史、韓峰、森口茂樹、福永浩司
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肥大心筋細胞におけるSigma-1受容体による細胞内カルシウム制御2011

    • Author(s)
      福永浩司
    • Organizer
      第21回日本循環薬理学会
    • Place of Presentation
      岡山
    • Year and Date
      2011-12-02
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 心筋細胞ミトコンドリアカルシウム輸送におけるsigma-1受容体の役割2011

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      第21回日本循環薬理学会
    • Place of Presentation
      岡山
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規認知機能改善薬sunifiramの作用機序に関する研究2011

    • Author(s)
      田中智哉、森口茂樹、福永浩司
    • Organizer
      第50回記念日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新生仔期腹側海馬(NVH)損傷ラットにおける認知機能障害とCaMKII活性低下の関連性2011

    • Author(s)
      矢吹悌、森口茂樹、塩田倫史、中川西修、小野木弘志、丹野孝一、只野武、福永浩司
    • Organizer
      第50回記念日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心臓型脂肪酸結合蛋白質欠損マウスにおける不安様行動の神経機序2011

    • Author(s)
      山本由似、塩田倫史、大和田祐二、福永浩司
    • Organizer
      第33回生物学的精神医学会若手研究者育成プログラム
    • Place of Presentation
      東京
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] eNOSの発現とリン酸化反応を介したフルボキサミンの心機能改善作用2011

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      第11回日本NO学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新生仔期腹側海馬(NVH)損傷ラット前脳におけるCaKII機能低下と行動異常2011

    • Author(s)
      矢吹悌、森口茂樹、中川西修、小野木弘志、只野武、塩田倫史、福永浩司
    • Organizer
      第20回神経行動薬理若手研究者の集い
    • Place of Presentation
      東京
    • Year and Date
      2011-03-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stimulation of sigma-1 receptor improves cognitive functions through CaMKII activation2011

    • Author(s)
      Fukunaga K, Moriguchi S, Yamamoto Y, Shioda N
    • Organizer
      Society for neuroscience, Neuroscience meeting 2011
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] ATRX変異精神遅滞マウスにおけるスパイン形態異常2011

    • Author(s)
      福永浩司、塩田倫史、別府秀幸、北島勲
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      石川
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] バナジウム化合物の心臓保護薬としての有用性2011

    • Author(s)
      福永浩司、Md. Shenuarin
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 圧負荷による血管障害に対するフルボキサミンのシグマ1受容体を介する血管保護作用2011

    • Author(s)
      福永浩司、田頭秀章、Md. Shenuarin Bhuiyan
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 心臓型脂肪酸結合蛋白質欠損マウスにおける不安様行動の神経機序2011

    • Author(s)
      山本由似、塩田倫史、大和田祐二、福永浩司
    • Organizer
      第33回生物学的精神医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心臓型脂肪酸結合蛋白質欠損マウスの不安様行動の神経機序2011

    • Author(s)
      山本由似、塩田倫史、大和田祐二、福永浩司
    • Organizer
      第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] MPTP処置パーキンソン病モデルマウスにおける認知機能障害とCaMキナーゼII活性低下の関連性2011

    • Author(s)
      森口茂樹、矢吹悌、福永浩司
    • Organizer
      第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳内sigma-1受容体の新規スプライスバリアントsigma-1 short受容体の発現と機能2011

    • Author(s)
      石川潔、塩田倫史、福永浩司
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      石川
    • Related Report
      2011 Annual Research Report
  • [Presentation] 嗅球摘出マウスにおけるシグマ1受容体活性化による認知機能障害の改善2011

    • Author(s)
      森口茂樹、山本由似、福永浩司
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      石川
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質欠損マウスにおける不安様行動の脳内機構2011

    • Author(s)
      山本由似、塩田倫史、大和田祐二、福永浩司
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規sigma-1受容体スプライスバリアントによるミトコンドリア内カルシウム濃度の制御2011

    • Author(s)
      石川潔、塩田倫史、福永浩司
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋小胞体-ミトコンドリアのカルシウム連関におけるsigma-1受容体の役割2011

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stimulation of sigma-1 receptor improves cognitive functions through Ca MKII activation2011

    • Author(s)
      K.Fukunaga, S.Moriguchi, Y.Yamamoto, N.Shioda
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of novel Alzheimer's therapeutic, ST101 in brain functions2011

    • Author(s)
      Y.Yamamoto, N.Shioda, S.Moriguchi, K.Fukunaga
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification and characterization of a novel sigma-1 receptor splicing variant in mouse brain2011

    • Author(s)
      N.Shioda, K.Ishikawa, K.Fukunaga
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質欠損マウスの不安様行動の神経化学的機序2011

    • Author(s)
      山本由似、塩田倫史、大和田祐二、福永浩司
    • Organizer
      第39回薬物活性シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心臓におけるsigma-1受容体の役割とsigma-1受容体アゴニストの心筋保護作用2011

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      第22回霧島神経薬理フォーラム
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Non genomic cardioprotective effect of DHEA on cardiac hypertrophy. Comparison with 17beta-estradiol-induced cardioprotection2011

    • Author(s)
      Tagashira H, Bhyuiyan MS, Shioda N, Fukunaga K.
    • Organizer
      Basic Cardiovascular Sciences 2011 Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] エストロゲンおよびデヒドロエピアンドロステロンの異なる心臓保護作用2011

    • Author(s)
      田頭秀章、福永浩司
    • Organizer
      第12回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      富山
    • Related Report
      2011 Annual Research Report
  • [Presentation]2011

    • Author(s)
      田頭秀章、Md.Shenuarin Bhuiyan、塩田倫史、福永浩司
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] DHEA処置によるシグマ1受容体の活性化は嗅球摘出マウスにおける認知機能障害をCaMKII、PKC、ERKの活性化を介して改善する2011

    • Author(s)
      森口茂樹、山本由似、生野達也、福永浩司
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳内Sigma-1受容体の新しいスプライスバリアントSigma-1 short受容体の発現とその機能2011

    • Author(s)
      塩田倫史、石川潔、福永浩司
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心肥大と機能障害に対するフルボキサミンとパロキセチンの異なる薬理作用2011

    • Author(s)
      田頭秀章、Md.Shenuarin Bhuiyan、塩田倫史、福永浩司
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニューロステロイドであるDHEAはシグマ1受容体を刺激して虚血に伴う神経細胞死を抑制する2011

    • Author(s)
      生野達也、塩田倫史、福永浩司
    • Organizer
      第84回薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sigma-1受容体作用薬は大動脈狭窄に伴う心肥大と心機能障害を抑制する2010

    • Author(s)
      田頭秀章、Md.Shenuarin,Bhuiyan、塩田倫史、福永浩司
    • Organizer
      第49回日本薬学会支部会
    • Place of Presentation
      福島
    • Year and Date
      2010-12-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経ステロイドはSigma-1受容体を介して虚血性神経細胞死を抑制する2010

    • Author(s)
      生野達也、塩田倫史、福永浩司
    • Organizer
      第49回日本薬学会支部会
    • Place of Presentation
      福島
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ドパミンD2受容体に対する脂肪酸結合蛋白質の機能的役割2010

    • Author(s)
      塩田倫史、山本由似、大和田祐二、福永浩司
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] SSRIによるSigma-1受容体の活性化と心筋保護作用2010

    • Author(s)
      田頭秀章、Md.Shenuarin Bhuiyan、塩田倫史、福永浩可
    • Organizer
      次世代を担う創薬・医藤理シ麻ジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Na+/Ca2+交換体(NCX)欠損マウスにおけるカルシウム/カルモデュリン依存性プロテインキナーゼIIの機能低下と認知機能障害2010

    • Author(s)
      森口茂樹、喜多紗斗美、岩本隆宏、福永浩司
    • Organizer
      第61回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生仔期腹側海馬損傷ラットの前頭前皮質における興奮性神経伝達機能低下と統合失調症様行動評価2010

    • Author(s)
      矢吹悌、森口茂樹、中川西修、小野木弘志、只野武、福永浩司
    • Organizer
      第61回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] AD/HDモデルラットにおける前頭前皮質の機能障害とそのメカニズム2010

    • Author(s)
      前田智美、塩田倫史、松本真知子、平出幸子、富樫廣子、福永浩司
    • Organizer
      第61回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生仔期腹側海馬損傷ラット前頭前皮質と海馬における機能低下2010

    • Author(s)
      矢吹悌、森口茂樹、中川西修、小野木弘志、只野武、福永浩司
    • Organizer
      第14回活性アミンに関するワークショップ
    • Place of Presentation
      仙台
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 精神遅滞モデルマウスのスパイン形態異常とそのメカニズム2010

    • Author(s)
      塩田倫史、別府秀幸、北島勲、福永浩司
    • Organizer
      日本生化学会東北支部第76回例会・シンポジウム
    • Place of Presentation
      福島
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dysregulation of PP1 and CaMKII activities accounts for abnrmal dendritic spine formation in ATRX mental retardation mice2010

    • Author(s)
      Fukunaga K, Shioda N, Beppu H, Kitajima I
    • Organizer
      第33回 日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Downregulation of cardiac sigma-1 receptor in transverse aortic constriction (TAC)-induced cardiac hypertrophy2010

    • Author(s)
      Fukunaga K, Tagashira H
    • Organizer
      The 9th Japan-Korea jointSymposium on Brain Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Final Research Report
  • [Presentation] 薬剤誘導による脳虚血耐性機構2010

    • Author(s)
      福永浩司、塩田倫史
    • Organizer
      第38回薬物活性シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質欠損マウスにおけるアラキドン酸代謝と情動行動異常2010

    • Author(s)
      福永浩司、山本由似、塩田倫史、大和田祐二
    • Organizer
      第12回応用薬理シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質の新しい標的分子としてのドパミンD2受容体2010

    • Author(s)
      福永浩司、竹内有輔、塩田倫史
    • Organizer
      第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Stimulation of Akt/eNOS signaling through Sigma-1 receptor ameliorates pressure overload-induced cardiac hypertrophy in ovariectomized rats2010

    • Author(s)
      Fukunaga K, Shioda N, Tagashira H, Bhyuiyan MS
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel cognitive enhancer, Spino[Imidazo[1,2-A]Pyridine-3,2-Indan]-2(3H)-One (ZSET1446), promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice2010

    • Author(s)
      Fukunaga K, Yamamoto Y, Moriguchi S and Shioda N
    • Organizer
      InternationalConference on Alzheimer's Disease
    • Place of Presentation
      Hawaii
    • Related Report
      2012 Final Research Report
  • [Presentation] Aberrant CaMKII activity is associated with abnormal dendritic spine formation in ATRX metal retardation model mice2010

    • Author(s)
      Fukunaga K, Shioda N, Beppu H, Li E, Kitajima I
    • Organizer
      Francis Crick Symposium on Neuroscience
    • Place of Presentation
      Suzhou, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Dysregulation of PP1 and CaMKII activities accounts for abnrmal dendritic spine formation in ATRX mental retardation mice2010

    • Author(s)
      Kohji Fukunaga, Norifumi Shioda, Hideyuki Beppu, Isao Kitajima
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Downregulation of cardiac sigma-1 receptor in transverse aortic constriction (TAC)-induced cardiac hypertrophy2010

    • Author(s)
      Kohji Fukunaga, Hideaki Tagashira
    • Organizer
      The 9th Japan-Korea joint Symposium on Bra in Sciences, and Cardiac and Smooth MuscleS
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impairment of the higher brain function induced by orexin released during food intake2010

    • Author(s)
      Yutaka Oomura, Shuji Aou, Kohji Fukunaga, Kazuo Sasaki
    • Organizer
      The 9th Japan-Korea joint Symposium on Bra in Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] SSRIによる心筋保護作用とそのメカニズム2010

    • Author(s)
      田頭秀章、Md.Shenuarin, Bhuiyan、塩田倫史、福永浩司
    • Organizer
      第20回日本循環薬理学会
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] NCX3欠損マウスにおける自発運動量の充進と細胞内カルシウム恒常性の異常2010

    • Author(s)
      森口茂樹、喜多紗斗美、岩本隆宏、福永浩司
    • Organizer
      第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report
  • [Presentation] ドパミンD2L受容体の細胞内シグナル伝達機構と脂肪酸結合蛋白質の関与2010

    • Author(s)
      塩田倫史、石川潔、福永浩司
    • Organizer
      第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質欠損マウスにおけるハロペリドール誘導カタレプシー亢進の神経機序2010

    • Author(s)
      山本由似、塩田倫史、大和田祐二、福永浩司
    • Organizer
      第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report
  • [Presentation] ADHDモデルラットにおける前頭前野領域の機能障害とそのメカニズム2010

    • Author(s)
      前田智美、塩田倫史、松本真知子、平出幸子、富樫廣子、福永浩司
    • Organizer
      第20回日本臨床精神神経薬理学会第40回日本祥経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質によるドパミンD2受容体の機能調節2010

    • Author(s)
      塩田倫史、山本由似、大和田拓二、福永浩司
    • Organizer
      生体機能と創薬シンポジウム2010
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗うつ薬FluvoxamineによるSigma-1受容体を介する心筋保護効果2010

    • Author(s)
      田頭秀章、Md.Shenuarin Bhuiyan、塩田倫史、福永浩司
    • Organizer
      生体機能と創薬シンポジヴム2010
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] メタンフヱタミン誘発行動逆耐性の機能不全にはCaMキナーゼII活性異常が関与する2010

    • Author(s)
      森口茂樹、竹島浩、福永浩司
    • Organizer
      日本神経化学会(Neuro2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質によるドパミンD2受容体の制御機構2010

    • Author(s)
      塩田倫史、山本由似、渡辺雅彦、大和田祐二、福永浩司
    • Organizer
      日本神経化学会(Neuro2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] セロトニンによるCaMKIVとERKを介したCREBリン酸化反応2010

    • Author(s)
      笠原二郎、大村幸司、安達みなみ、福永浩司
    • Organizer
      日本神経化学会(Neuro2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 内因性空腹物質オレキシンは空間学習の可塑性を障害する2010

    • Author(s)
      大村裕、粟生修司、福永浩司、佐々木和男
    • Organizer
      日本神経化学会(Neuro2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impairment of cognitive function via decreased calcium/cakmo dulin-dependent protein kinase II activity in Na^+/Ca^2+ exchanger type-2 deficit mice.2010

    • Author(s)
      Shigeki Moriguchi, Satomi Kita, Takahiro Iwamoto, Kohji Fukunaga
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stimulation of Akt/eNOS signaling through Sigma-1 receptor a meliorates pressure overload-induced cardiac hypertrophy in ovariectomized rats.2010

    • Author(s)
      Kohji Fukunaga, Norifumi Shioda, Hideaki Tagashira, Shenuarin Md Bhuiyan
    • Organizer
      The 6th International Conference on the Bielegy, Chemistry, and Therapeutic Applicat ions of Nitric Oxide
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel cognitive enhancer, Spino[Imidazo[1,2-A]Pyridine-3,2-Indan]-2(3H)-One (ZSET1446), promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbect omized mice.2010

    • Author(s)
      Kohji Fukunaga, Yui Yamamoto, Shigeki Moriguchi, Norifumi Shioda
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      ホノルル、USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Memantine ameliorates the impairment of hippocampal long-term potentiation in olfactory bulbectomized mice.2010

    • Author(s)
      Shigeki Moriguchi, Yui Yamamote, Norifumi Shioda, Kohji Fukunaga
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      ホノルル、USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット脳虚血モデルにおけるバナジウム化合物VO(OPT)末梢投与による虚血耐性誘導と血管保護作用2010

    • Author(s)
      塩田倫史、鈴木寿栄、福永浩司
    • Organizer
      第11回Pharmaco-Hematology Symposium
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Aberrant CaMKII activity is associated with abnormal dendritic spine formation in ATRX metal retardation model mice.2010

    • Author(s)
      Kohji Fukunaga, Norifumi Shioda, Hideyuki Beppu, En Li, Isao Kitajima
    • Organizer
      Francis Crick Symposium on Neuroscience
    • Place of Presentation
      Suzhou, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sigma-1受容体賦活化による認知機能障害およびうつ様症状の改善効果

    • Author(s)
      森口茂樹、福永浩司
    • Organizer
      第22回神経行動薬理若手研究者の集い
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心筋sigma-1 受容体によるミトコンドリアカルシウム調節と心機能改善作用

    • Author(s)
      田頭秀章、長谷川英之、金井浩、福永浩司
    • Organizer
      第22回日本循環器薬理学会
    • Place of Presentation
      富山
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルツハイマー型認知症治療薬memantineの抗うつ作用のメカニズム

    • Author(s)
      杉村好彦、森口茂樹、塩田倫史、田頭秀章、福永浩司
    • Organizer
      第51回日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Related Report
      2012 Annual Research Report
  • [Presentation] PP2Cε依存的なセラミド輸送におけるGCP60の機能の検討

    • Author(s)
      篠田康晴、藤田宏介、永浦裕子、小林孝安、田村眞理、福永浩司
    • Organizer
      第63回日本薬理学会北部会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心圧負荷モデルにおける SA4503 の心筋保護作用

    • Author(s)
      平野光河、田頭秀章、福永浩司
    • Organizer
      第63回日本薬理学会北部会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症モデル、新生仔期腹側海馬損傷ラットの認知機能障害メカニズム

    • Author(s)
      矢吹悌、森口茂樹、塩田倫史、中川西修、小野木弘志、丹野孝一、只野武、福永浩司
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム 2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロテインホスファターゼ 1 による CaMKIIδ3 の核内移行制御とその機能的役割

    • Author(s)
      澤井優広、塩田倫史、福永浩司
    • Organizer
      日本生化学会 東北支部 第78回 例会・シンポジウム
    • Place of Presentation
      山形
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心筋細胞におけるsigma-1 受容体を介したATP 産生機構

    • Author(s)
      田頭秀章、塩田倫史、福永浩司
    • Organizer
      日本生化学会 東北支部 第78回 例会・シンポジウム
    • Place of Presentation
      山形
    • Related Report
      2012 Annual Research Report
  • [Presentation] 注意欠陥/多動性障害モデルラットにおける前頭前皮質領域の機能障害

    • Author(s)
      前田智美、塩田倫史、松本真知子、平出幸子、富樫廣子、福永浩司
    • Organizer
      第21回霧島神経薬理フォーラム
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.tohoku.ae.jp/~yakuri/yakuri_top.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳機能改善薬2012

    • Inventor(s)
      福永浩司
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2012-01-25
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi