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RNA Biology for Stress Assessment and Prediction of Major Depression

Research Project

Project/Area Number 22390146
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionThe University of Tokushima

Principal Investigator

ROKUTAN Kazuhito  徳島大学, 大学院・へルスバイオサイエンス研究部, 教授 (10230898)

Co-Investigator(Kenkyū-buntansha) KUWANO Yuki  徳島大学, 大学院・へルスバイオサイエンス研究部, 助教 (00563454)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywordsストレス / うつ病 / 遺伝子発現 / RNAマーカー / マイクロRNA
Research Abstract

This research project was designed to identify novel RNA markers for stress assessment and prediction of major depressive disorders. We reported acute stress-specific alternative splicing of SMG-1in peripheral blood (Neurosci Lett 2010) and chronic stress-specific reduction of a GR-beta isoform (Stress 2011). We also investigated stress-responsive microRNAs (miRNAs) in peripheral blood. We reported miR-16, miR-144, and miR144* as acute stress-responsive miRNAs (nuerosci Lett 2012).We also identified 7 miRNAs as chronic stress-responsive miRNAs.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(37 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Remarks

  • [Journal Article] Down-regulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells2014

    • Author(s)
      Kurokawa K, Akaike Y, Masuda K, Kuwano Y, Nishida K, Yamagishi N, Kajita K, Tanahashi T, Rokutan K.
    • Journal Title

      J Gastroenterol.

      Volume: 33 Pages: 1407-1417

    • DOI

      10.1038/onc.2013.86

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells2013

    • Author(s)
      Kurokawa K, Akaike Y, Masuda K, Kuwano Y, Nishida K, Yamagishi N, Kajita K, Tanahashi T, Rokutan K
    • Journal Title

      Oncogene

      Volume: 86

    • Related Report
      2012 Final Research Report
  • [Journal Article] Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells2013

    • Author(s)
      Yamagishi N, Teshima-Kondo S, Masuda K, Nishida K, Kuwano Y, Dang DT, Dang LH, Nikawa T, Rokutan K.
    • Journal Title

      BMC Cancer.

      Volume: 13 Pages: 1-11

    • DOI

      10.1186/1471-2407-13-229

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ets1 and heat shock factor 1 regulate transcription of the Transformer 2beta gene in human colon cancer cell2013

    • Author(s)
      Kajita K, Kuwano Y, Kitamura N, Satake Y, Nishida K, Kurokawa K, Akaike Y, Honda M, Masuda K, Rokutan K
    • Journal Title

      J Gastroenterol

    • URL

      http://link.springer.com/article/10.1007%2Fs00535-012-0745-2

    • Related Report
      2012 Final Research Report
  • [Journal Article] Molecular features of triple negative breast cancers by genome-wide gene expression profiling analysis2013

    • Author(s)
      Komatsu M, Yoshimaru T, Matsuo T, Kiyotani K, Miyoshi Y, Tanahashi T, Rokutan K, Yamaguchi R, Saito A, Imoto S, Miyano S, Nakamura Y, Sasa M, Shimada M, Katagiri T.
    • Journal Title

      Int J Oncol

      Volume: 42(2) Pages: 478-506

    • DOI

      10.3892/ijo.2012.1744

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations between chronotype and salivary endocrinological stress markers.2013

    • Author(s)
      Toda M, Kawai T, Takeo K, Rokutan K, Morimoto K
    • Journal Title

      Endocr Res.

      Volume: 38 Pages: 1-7

    • DOI

      10.3109/07435800.2012.683225

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating cytokine signatures in healthy medical students exposed to academic examination stress2013

    • Author(s)
      Kan C, Kawakami N, Karasawa M, Love GD, Coe CL, Miyamoto Y, Ryff CD, Kitayama S, Curhan KB, Markus HR.
    • Journal Title

      Psychophysiology

      Volume: 49(7) Pages: 991-7

    • DOI

      10.1111/j.1469-8986.2012.01371.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ets1 and heat shock factor 1 regulate transcription of the Transformer 2beta gene in human colon cancer cells2013

    • Author(s)
      Kajita K
    • Journal Title

      Journal of Gastroenterology

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNAs miR-144/ 144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students2012

    • Author(s)
      Katsuura S, Kuwano Y, Yamagishi N, Kurokawa K, Kajita K, Akaike Y, Nishida K, Masuda K, Tanahashi T, Rokutan K.
    • Journal Title

      Neuroscience Letters

      Volume: 516 Pages: 79-84

    • DOI

      10.1016/j.neulet.2012.03.062

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells.2012

    • Author(s)
      Kurokawa K, Tanahashi T, Iima T, Yamamoto Y, Akaike Y, Nishida K, Masuda K, Kuwano Y, Murakami Y, Fukushima M, Rokutan
    • Journal Title

      J Gastroenterol.

      Volume: 47 Pages: 883-895

    • DOI

      10.1007/s00535-012-0547-6

    • NAID

      10031051201

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] General RBP expression in human tissues as a function of age2012

    • Author(s)
      Masuda K, et al.
    • Journal Title

      Ageing research reviews

      Volume: 11(4) Pages: 423-31

    • DOI

      10.1016/j.arr.2012.01.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating vascular endothelial growth factor is independently and negatively associated with trait anxiety and depressive mood in healthy Japanese university students2012

    • Author(s)
      Katsuura S, Kamezaki Y, Yamagishi N, Kuwano Y, Nishida K, Masuda K, Tanahashi T, Kawai T, Arisawa K, Rokutan K.
    • Journal Title

      Int J Psychophysio

      Volume: 81 Pages: 38-43

    • DOI

      10.1016/j.ijpsycho.2011.04.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating cytokine signatures in healthy medical students exposed to academic examination stress2012

    • Author(s)
      Kamezaki Y, et al
    • Journal Title

      Psychophysiology

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells2012

    • Author(s)
      Kurokawa K, et al
    • Journal Title

      Journal of Gastroenterology

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] General RBP expression in human tissues as a function of age2012

    • Author(s)
      Masuda K, et al
    • Journal Title

      Aging Research Review

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic academic stress on mental state and expression of glucocorticoid receptor alpha and beta isoforms in healthy Japanese medical students2011

    • Author(s)
      Kurokawa K, Tanahashi T, Murata A, Akaike Y, Katsuura S, Nishida K, Masuda K, Kuwano Y, Kawai T, Rokutan K.
    • Journal Title

      Stress

      Volume: 14 Pages: 431-438

    • DOI

      10.3109/10253890.2011.555930

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autism children2011

    • Author(s)
      Kuwano Y, Kamio Y, Kawai T, Katsuura S, Inada N, Takaki A, Rokutan K.
    • Journal Title

      PloS ONE

      Volume: 6

    • DOI

      10.1371/journal.pone.0024723

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Skipping of an alternative intron in the srsf1 3' untranslated region increases transcript stabilit2011

    • Author(s)
      Akaike Y, Kurokawa K, Kajita K, Kuwano Y, Masuda K, Nishida K, Wan Kang S, Tanahashi T, Rokutan K
    • Journal Title

      J Med Invest

      Volume: 58 Pages: 180-187

    • URL

      https://www.jstage.jst.go.jp/article/jmi/58/3,4/58_3,4_180/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children2011

    • Author(s)
      Kuwano Y, et al
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skipping of an alternative intron in the srsfl 3' untranslated region increases transcript stability2011

    • Author(s)
      Akaike Y, et al
    • Journal Title

      Journal of Medical Investigation

      Volume: 58 Pages: 180-187

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating vascular endothelial growth factor is independently and negatively associated with trait anxiety and depressive mood in healthy Japanese university students2011

    • Author(s)
      Katsuura S, et al
    • Journal Title

      International Journal of Psychophysiology

      Volume: 81 Pages: 38-43

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic academic stress on mental state and expression of glucocorticoid receptor α and β isoforms in healthy Japanese medical students2011

    • Author(s)
      Kurokawa K, et al
    • Journal Title

      Stress

      Volume: 14 Pages: 431-438

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic academic stress on mental state an expression of glucocorticoid receptor α and β isoforms in healthy Japanese medical students2011

    • Author(s)
      Ken Kurokawa, et al.
    • Journal Title

      Stress

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-18 deficiency reduces neuropeptide gene expressions in the mouse amygdala related with behavioral change2010

    • Author(s)
      Yamamoto Y, Tanahashi T, Katsuura S, Kurokawa K, Nishida K, Kuwano Y, Kawai T, Teshima-Kondo S, Chikahisa S, Tsuruo Y, Sei H, Rokutan K.
    • Journal Title

      J Neuroimmunol

      Volume: 229 Pages: 129-139

    • DOI

      10.1016/j.jneuroim.2010.07.024

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brief naturalistic stress induces an alternative splice variant of SMG-1 lacking exon 63 in peripheral leukocytes2010

    • Author(s)
      Kurokawa K, Kuwano Y, Tominaga K, Kawai T, Katsuura S, Yamagishi N, Satake Y, Kajita K, Tanahashi T, Rokutan K
    • Journal Title

      Neurosci Lett

      Volume: 484 Pages: 128-132

    • DOI

      10.1016/j.neulet.2010.08.031

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput screening of brief naturalistic stress-responsive cytokines in university students taking examinations2010

    • Author(s)
      Katsuura S, Kamezaki Y, Tominaga K, Masuda K, Nishida K, Yamamoto Y, Takeo K, Yamagishi N, Tanahashi T, Kawai T, Rokutan K
    • Journal Title

      Int J Psychophysiol

      Volume: 77 Pages: 135-140

    • DOI

      10.1016/j.ijpsycho.2010.05.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brief naturalistic stress induces an alternative splice variant of SMG-1 lacking exon 63 in peripheral leukocytes2010

    • Author(s)
      Ken Kurokawa, et al.
    • Journal Title

      Neuroscience Letters

      Volume: 484 Pages: 128-132

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-18 deficiency reduces neuropeptide gene expressions in the mouse amygdala related with behavioral change2010

    • Author(s)
      Yuta Yamamoto, et al.
    • Journal Title

      Journal of Neuroimmunology

      Volume: 229 Pages: 129-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput screening of brief naturalistic stress-responsive cytokines in university students taking examinations2010

    • Author(s)
      Sakurako Katsuura, et al.
    • Journal Title

      International Journal of Psychophysiology

      Volume: 77 Pages: 135-140

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝子発現解析からみた慢性疲労症候群の病態2011

    • Author(s)
      六反一仁
    • Organizer
      第7回日本疲労学会総会
    • Place of Presentation
      名古屋大学(名古屋市)(招待講演)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ストレスマーカーの現状2010

    • Author(s)
      六反一仁
    • Organizer
      第26回日本ストレス学会学術総会教育講演
    • Place of Presentation
      福岡市
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心と遺伝子を探るストレスゲノミクス研究2010

    • Author(s)
      六反一仁
    • Organizer
      2010日本歯周痛学会秋期学術大会(第53回)
    • Place of Presentation
      高松市(特別講演)
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alternative splice variants of SMG-1 as a potential marker for brief naturalistic stressors peripheral leukocytes2010

    • Author(s)
      Kazuhito Rokutan
    • Organizer
      The 7^<th> World Congress on Stress
    • Place of Presentation
      Leiden, Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-throughput screening of brief naturalistic stress-responsive cytokines in Japanese university students taking examinations2010

    • Author(s)
      Kazuhito Rokutan
    • Organizer
      The 7^<th> World Congress on Stress
    • Place of Presentation
      Leiden, Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-throughput screening of immunomodulators identifies VEGF as a potential biomarker for trait anxiety and depressive mood in healthy Japanese university students2010

    • Author(s)
      Kazuhito Rokutan
    • Organizer
      The 7^<th> World Congress on Stress
    • Place of Presentation
      Leiden, Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] The mechanism of transformer 2-□ gene expression in response to oxidative stress in human colon epithelial cells2010

    • Author(s)
      Kazuhito Rokutan
    • Organizer
      Digestive Disease Week 2010
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tokushima-u.ac.jp/med/culture/sutoresu/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-22   Modified: 2019-07-29  

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