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Is acupuncture placebo?: Investigating efficacy and mechanism of acupuncture using world's first double-blind needles.

Research Project

Project/Area Number 22390147
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTokyo Ariake University of Medical and Health Sciences

Principal Investigator

TAKAKURA Nobuari  東京有明医療大学, 保健医療学部, 教授 (60563400)

Co-Investigator(Kenkyū-buntansha) YAJIMA Hiroyoshi  東京有明医療大学, 保健医療学部, 講師 (00563412)
TAKAYAMA Miho  東京有明医療大学, 保健医療学部, 助教 (20563414)
Research Collaborator KAWASE Akiko  日本鍼灸理療専門学校, 常勤教員
KAPTCHUK Ted J.  Harvard Medical School, 教授
JIAN Kong  Harvard Medical School, 准教授
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords鍼 / プラセボ / ダブルブラインド / RCT / 肩こり / EBM
Outline of Final Research Achievements

To determine the efficacy of acupuncture for neck/shoulder stiffness, we conducted a randomized, double-blind (practitioner-patient), placebo-controlled study including four arms: treatment with penetrating needles (penetrating treatment), treatment with skin-touch placebo needles (skin-touch placebo treatment), treatment with no-touch placebo needles (no-touch placebo treatment) and control with no treatment (no-treatment control).
Each of penetrating, skin-touch and no-touch placebo treatments has therapeutic effect on neck/shoulder stiffness comparing with no-treatment control, but there was no significant difference in alleviation of stiffness between the three treatments. There was change of blood circulation exclusively in penetrating treatment. The results indicate that acupuncture treatment, whether treatment involving body penetration or not, subjective stiffness would be alleviated, but blood circulation would be improved only when needle is inserted.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2015 2014 2013 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Invited: 1 results)

  • [Journal Article] The potential of double blinding with two placebo acupuncture needles: a randomized controlled pilot-trial2015

    • Author(s)
      Takayama M, Yajima H, Kawase A, Homma I, Izumizaki M, Takakura N
    • Journal Title

      Medicines

      Volume: 2 Issue: 1 Pages: 11-27

    • DOI

      10.3390/medicines2010011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Can acupuncture treatment be double-blinded? An evaluation of double-blind acupuncture treatment of postoperative pain.2015

    • Author(s)
      Vase L, Baram S, Takakura N, Takayama M, Yajima H, Kawase A, Schuster L, Kaptchuk TJ, Schou S, Jensen TS, Zachariae R, Svensson P
    • Journal Title

      PLoS One

      Volume: 10(3) Issue: 3 Pages: e0119612-e0119612

    • DOI

      10.1371/journal.pone.0119612

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design of a randomised acupuncture trial on functional neck/shoulder stiffness with two placebo controls.2014

    • Author(s)
      Takakura N, Takayama M, Kawase A, Kaptchuk TJ, Kong J, Yajima H
    • Journal Title

      BMC Complementary and Alternative Medicine

      Volume: 14 Issue: 1 Pages: 246-246

    • DOI

      10.1186/1472-6882-14-246

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Specifying the nonspecific components of acupuncture analgesia.2013

    • Author(s)
      Vase L, Baram S, Takakura N, Yajima H, Takayama M, Kaptchuk TJ, Schou S, Jensen TS, Zachariae R, Svensson P
    • Journal Title

      Pain

      Volume: 154(9) Issue: 9 Pages: 1659-1667

    • DOI

      10.1016/j.pain.2013.05.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Double-blind acupuncture needle: a potential tool to investigate the nature of pain and pleasure.2013

    • Author(s)
      Takakura N, Takayama M, Kawase A, Kaptchuk TJ, Yajima H.
    • Journal Title

      ISRN Pain

      Volume: 2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tapping-in Method (Skin Penetration Technique) with a Placebo Needle for Double-Blind Acupuncture Trials.2013

    • Author(s)
      Takakura N, Takayama M, Kawase A, Yajima H.
    • Journal Title

      The Journal of Alternative and Complementary Medicine

      Volume: 19(4) Issue: 4 Pages: 308-312

    • DOI

      10.1089/acm.2012.0056

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double blinding with a new placebo needle: a validation study on participant blinding.2011

    • Author(s)
      Takakura N, Takayama M, Kawase A, Yajima H.
    • Journal Title

      Acupuncture in Medicine

      Volume: 29(3) Issue: 3 Pages: 203-207

    • DOI

      10.1136/aim.2010.002857

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double-blinding with a new placebo needle ; a further validation study2010

    • Author(s)
      Takakura N, Takayama M, Yajima H
    • Journal Title

      Acupuncture in Medicine

      Volume: Vol.28 Pages: 144-148

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Introducing the possible double-blind needles into acupuncture research2014

    • Author(s)
      矢嶌裕義, 高山美歩, 高倉伸有
    • Organizer
      The 6th Korea-Japan Collaborative Workshop on Acupuncture Medicine (第6回鍼とEBM日韓ワークショップ)
    • Place of Presentation
      韓国キョンヒ大学
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ダブル(術者-患者)ブラインド用接触プラセボ鍼および非接触プラセボ鍼を用いた鍼治療の臨床試験におけるブラインド効果の検討2014

    • Author(s)
      高山美歩, 矢嶌裕義, 川瀬明子, 本間生夫, 泉崎雅彦, 高倉伸有
    • Organizer
      第318回昭和大学学士会例会
    • Place of Presentation
      昭和大学(東京都品川区)
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 鍼の刺入に伴う「痛み」と「不快感/心地良さ」の関係2014

    • Author(s)
      平川稚佳子, 高山美歩, 川瀬明子, 柳沢ゆかり, 矢嶌裕義, 高倉伸有
    • Organizer
      第63回全日本鍼灸学会学術大会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-05-16 – 2014-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Double-blind (practitioner-patient masking) placebo needle 6 -弾入法によるマスキング効果-2013

    • Author(s)
      川瀬明子, 平川稚佳子, 柳沢ゆかり, 高山美歩, 矢嶌裕義, 高倉伸有
    • Organizer
      第62回全日本鍼灸学会学術大会(九州大会)
    • Place of Presentation
      アクロス福岡(福岡県福岡市)
    • Year and Date
      2013-06-07 – 2013-06-09
    • Related Report
      2013 Annual Research Report
  • [Presentation] Double‐blind(practitioner‐patient masking)placebo needle 5―刺入鍼による患者マスキングの可能性―2012

    • Author(s)
      川瀬明子, 平川稚佳子, 柳沢ゆかり, 高山美歩, 矢嶌裕義, 高倉伸有.
    • Organizer
      第61回全日本鍼灸学会学術大会
    • Place of Presentation
      四日市市文化会館(三重県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A double-blind placebo needle for acupuncture research2010

    • Author(s)
      高倉伸有
    • Organizer
      全日本鍼灸学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Double-blind(practitioner-patient masking)placebo needle 4術者は刺鍼操作中に鍼の真偽がわかるのか?2010

    • Author(s)
      高山美歩
    • Organizer
      全日本鍼灸学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] ダブルブラインドクロスオーバー法による鍼の鎮痛効果2010

    • Author(s)
      矢罵裕義
    • Organizer
      全日本鍼灸学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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