| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Tsuyoshi 山口大学, 大学院・医学系研究科, 助教 (20569305)
TAKAMI Taro 山口大学, 大学院・医学系研究科, 講師 (60511251)
SAKAIDA Isao 山口大学, 大学院・医学系研究科, 教授 (80263763)
UCHIDA Koichi 山口大学, 医学部附属病院, 講師 (80397992)
YAMAMOTO Naoki 山口大学, 大学教育機構, 講師 (90448283)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
Our researches showed that autologous bone marrow derived cells (BMCs) were useful for liver regeneration therapy for liver cirrhosis. In these projects, we estimated characterization of bone marrow derived liver repair cells and demonstrated the mechanisms of liver repair by BMCs. We found that macrophage was effective to improve liver fibrosis in mice. In this project, we found that TNF signal is important to induce liver repair by BMC infusions. We found that bone marrow derived mesenchymal cells might be a new candidate-cell-fraction to repair liver fibrosis. Both TNF and Maid signal are important to regulate improvement of liver fibrosis by BMC infusion. These results are important to develop a new cell therapy using BMCs.
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