The basic research of the development of future generation cell therapy used bone marrow derived liver repaid cell
| Project/Area Number |
22390150
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TERAI Shuji 山口大学, 大学院・医学系研究科, 准教授 (00332809)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Tsuyoshi 山口大学, 大学院・医学系研究科, 助教 (20569305)
TAKAMI Taro 山口大学, 大学院・医学系研究科, 講師 (60511251)
SAKAIDA Isao 山口大学, 大学院・医学系研究科, 教授 (80263763)
UCHIDA Koichi 山口大学, 医学部附属病院, 講師 (80397992)
YAMAMOTO Naoki 山口大学, 大学教育機構, 講師 (90448283)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 再生医療 / 骨髄細胞 / Maid KO / TNFR1 KO / 肝臓修復 / HTVi 法 / FGF / HTVi法 / 肝再生 / Maid / 修復再生療法 / 肝線維化 / ABMi療法 / 遺伝子治療 |
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| Research Abstract |
Our researches showed that autologous bone marrow derived cells (BMCs) were useful for liver regeneration therapy for liver cirrhosis. In these projects, we estimated characterization of bone marrow derived liver repair cells and demonstrated the mechanisms of liver repair by BMCs. We found that macrophage was effective to improve liver fibrosis in mice. In this project, we found that TNF signal is important to induce liver repair by BMC infusions. We found that bone marrow derived mesenchymal cells might be a new candidate-cell-fraction to repair liver fibrosis. Both TNF and Maid signal are important to regulate improvement of liver fibrosis by BMC infusion. These results are important to develop a new cell therapy using BMCs.
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Report
(4 results)
Research Products
(100 results)
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[Journal Article] Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy2012
Author(s)
Terai S, Tanimoto H, Maeda M, Zaitsu J, Hisanaga T, Iwamoto T, Fujisawa K, Mizunaga Y, Matsumoto T, Urata Y, Marumoto Y, Hidaka I, Ishikawa T, Yokoyama Y, Aoyama K, Tsuchiya M, Takami T, Omori K, Yamamoto N, Segawa M, Uchida K, Yamasaki T, Okita K, Sakaida I
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Journal Title
J Gastroenterol
Volume: 47(5)
Pages: 491-497
NAID
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Peer Reviewed
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[Journal Article] Potential therapeutic application of intravenous autologous bone marrow infusion in patients with alcoholic liver cirrhosis2011
Author(s)
Saito T, Okumoto K, Haga H, Nishise Y, Ishii R, Sato C, Watanabe H, Okada A, Ikeda M, Togashi H, Ishikawa T, Terai S, Sakaida I, Kawata S
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Journal Title
Stem Cells Dev
Volume: 20(9)
Pages: 1503-1510
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Peer Reviewed
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[Journal Article] Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis2010
Author(s)
Kim JK, Park YN, Kim JS, Park MS, Paik YH, Seok JY, Chung YE, Kim HO, Kim KS, Ahn SH, Kim do Y, Kim MJ, Lee KS, Chon CY, Kim SJ, Terai S, Sakaida I, Han KH
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Journal Title
Cell Transplant
Volume: 19(10)
Pages: 1237-1246
Related Report
Peer Reviewed
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[Book] Liver Resident Stem Cell2012
Author(s)
Christina M Takiya, Bruno Dias Paredes, Luiz Fernando Quintanilha de Mesquita, Grazielle Suhett Dias, Lanuza Alaby Pinheiro Faccioli, Takami T, Terai S, Sakaida I
Publisher
ELSEVIER
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