the development of novel therapeutic arteriogenesis by nanoparticle-mediated endothelial cell selective delivery system

• Project/Area Number: 22390160
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyushu University
• Principal Investigator: EGASHIRA Kensuke 九州大学, 医学研究院, 教授 (60260379)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 分子血管病態学 / ナノテクノロジー / DDS / 治療的血管新生 / ドラッグデリバリーシステム / ナノテク

Research Abstract

Currently, there is no effective medicinal therapy for severe ischemic diseases such as critical limb ischemia (CLI). We hypothesized that nanoparticle (NP)-mediated cell-selective delivery of statins to vascular endothelium would more effectively and int

Research Products

• [Journal Article] ナノ粒子DDSを用 いた血管新生治療法の開発 (2013)
  • Author(s): 的場哲哉、江頭健輔
  • Journal Title: Bio Clinica北隆館 Volume: 28(5) Pages: 35-39
• [Journal Article] ナノ粒子DDSを用いた血管新生治療法の開発 (2013)
  • Author(s): 的場哲哉
  • Journal Title: Bio Clinica Volume: 28(5) Pages: 35-39
• [Journal Article] Nanoparticle-Mediated Delivery of Pioglitazone Enhances Therapeutic Neovascularization in a Murine Model of Hindlimb Ischemia. (2012)
  • Author(s): Nagahama R, Egashira K ,他
  • Journal Title: Arteri oscl er Thromb Vasc Biol. Volume: 32(10) Issue: 10 Pages: 2427-2434
  • DOI: 10.1161/atvbaha.112.253823
  • Peer Reviewed
• [Journal Article] anoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension (2011)
  • Author(s): Chen L, Egashira K , 他9名
  • Journal Title: Hypertension. Volume: 57 (2) Pages: 343-350
• [Journal Article] Imatinib Mesylate-Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Neointimal Formation in Porcine Coronary Arteries. (2011)
  • Author(s): Masuda S, Egashira K , 他9名
  • Journal Title: J Atheroscler Thromb. Volume: 18 (12) Pages: 1043-1053
  • NAID: 130004845354
• [Journal Article] 「血管内皮細胞選択的ナノDDS技術」を活用した低侵襲ナノ医療の開発 (2011)
  • Author(s): 中野覚、江頭健輔
  • Journal Title: 臨床評価臨床評価刊行会 Volume: 39(2) Pages: 300-304
• [Journal Article] Nanoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension (2011)
  • Author(s): Chen L, et al
  • Journal Title: Hypertension Volume: 57(2) Issue: 2 Pages: 343-350
  • DOI: 10.1161/hypertensionaha.110.157032
  • Peer Reviewed
• [Journal Article] Imatinib Mesylate-Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Neointimal Formation in Porcine Coronary Arteries (2011)
  • Author(s): Masuda S, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 18 Issue: 12 Pages: 1043-1053
  • DOI: 10.5551/jat.8730
  • NAID: 130004845354
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] 「血管内皮細胞選択的ナノDDS技術」を活用した低侵襲ナノ医療の開発 (2011)
  • Author(s): 中野覚, 他
  • Journal Title: 臨床評価 Volume: 39(2) Pages: 300-304
• [Journal Article] Nanoparticle-Mediated Endothelial Cell-Selective Delivery of Pitavastatin Induces Functional Collateral Arteries (Therapeutic Arteriogenesis) in a Rabbit Model of Chronic Hindlimb Ischemia. (2010)
  • Author(s): Oda S, Egashira K ,(他6名)
  • Journal Title: J Vase Surg Volume: 52(2) Pages: 412-420
• [Journal Article] 総説ナノテクノロジーの循環器疾患への応用 (2010)
  • Author(s): 中野覚、江頭健輔
  • Journal Title: 呼吸と循環医学書院 Volume: 58(5) Pages: 495-501
• [Journal Article] 血管医学から先端医療研究開発への展開 (2010)
  • Author(s): 江頭健輔
  • Journal Title: 血管医学メディカルレビュー社 Volume: 11(3)
• [Journal Article] Nanoparticle-Mediated Endothelial Cell-Selective Delivery of Pitavastatin Induces Functional Collateral Arteries (Therapeutic Arteriogenesis) in a Rabbit Model of Chronic Hindlimb Ischemia. (2010)
  • Author(s): Oda S, et al.
  • Journal Title: J Vasc Surg. Volume: 52(2) Pages: 412-420
  • Peer Reviewed
• [Journal Article] 総説 ナノテクノロジーの循環器疾患への応用 (2010)
  • Author(s): 中野覚、江頭健輔
  • Journal Title: 呼吸と循環 Volume: 58(5) Pages: 495-501
• [Journal Article] 血管医学から先端医療研究開発への展開 (2010)
  • Author(s): 江頭健輔
  • Journal Title: 血管医学 Volume: 11(3)
• [Presentation] ナノテクノロジーを用いたdrugdelivery system(ナノDDS)による心血管病に対する革新的治療実用化、 (2012)
  • Author(s): 江頭健輔
  • Organizer: 第32回日本川崎病学会・学術集会(招待講演)
  • Place of Presentation: 品川インターシティホール
  • Year and Date: 2012-10-13
• [Presentation] Nanotechnology-Based DDS for Patients with Critical Limb Ischemia (2012)
  • Author(s): Egashira K
  • Organizer: The 2012 Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis (14)
  • Place of Presentation: 台北市福華國際文教會館、台湾
  • Year and Date: 2012-09-23
• [Presentation] ナノテクノロジーを基盤とする動脈硬化プラーク破綻と虚血-再灌流傷害に対する新しい治療法の開発、 (2012)
  • Author(s): 江頭健輔
  • Organizer: 第44回日本動脈硬化学会総会・学術集会(招待講演)
  • Place of Presentation: ヒルトン福岡シーホーク
  • Year and Date: 2012-07-20
• [Presentation] Nanoparticle-mediated delivery of pitavastatin via pulse infusion drug delivery catheter attenuates neointima formation after balloon injury in porcine coronary arteries (2012)
  • Author(s): Egashira K
  • Organizer: The 4th Oriental Congress of Cardiology & The 5th AICT (MTAM,)
  • Place of Presentation: 上海国際会議中心、中国
  • Year and Date: 2012-05-26
• [Presentation] Impact of nanotechnology-based endothelial cell-selective delivery of pitavastatin for therapeutic angiogenesis in critical limbischemia (2012)
  • Author(s): Egashira K
  • Organizer: XVIInternationalSymposiumonAtherosclerosis
  • Place of Presentation: SydneyConventionandExhibitionCentre、オーストラリア
  • Year and Date: 2012-03-28
• [Presentation] Impact of nanotechnology-based endothelial cell-selective delivery of pitavastatin for therapeutic angiogenesis in critical limb ischemia (2012)
  • Author(s): Egashira K
  • Organizer: XVI International Symposium on Atherosclerosis
  • Place of Presentation: Sydney, Australia(Invited lecture)(招待講演)
  • Year and Date: 2012-03-28
• [Presentation] 血管内皮細胞選択的ナノDDS技術を活用した重症虚血性疾患に対する革新的低侵襲ナノ医療 (2012)
  • Author(s): 江頭健輔
  • Organizer: 重症下肢虚血治療検討会
  • Place of Presentation: グランド・ハイアット・福岡
  • Year and Date: 2012-03-10
• [Presentation] 血管内皮細胞選択的ナノDDS技術を活用した重症虚血性疾患に対する革新的低侵襲ナノ医療 (2012)
  • Author(s): 江頭健輔
  • Organizer: 重症下肢虚血治療検討会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2012-03-10
• [Presentation] 「ナノテクノロジー」を基盤 とする新しいPCIデバイス、治療的血管 新生と心筋梗塞治療一日本初の独創的医 療機器・医薬品の開発を目指して一 (2012)
  • Author(s): 江頭健輔
  • Organizer: 第2回 Strategy and Treatment For Cardiovascular Disease
  • Place of Presentation: 倉敷国際ホテル
  • Year and Date: 2012-02-25
• [Presentation] 「ナノテクノロジー」を基盤とする新しいPCIデバイス、治療的血管新生と心筋梗塞治療-日本初の独創的医療機器・医薬品の開発を目指して- (2012)
  • Author(s): 江頭健輔
  • Organizer: 第2回Strategy and Treatment For Cardiovascular Disease
  • Place of Presentation: 岡山(招待講演)
  • Year and Date: 2012-02-25
• [Presentation] Nanoparticle-mediated delivery of pitavastatin via pulse infusion drug delivery catheter attenuates neointima formation after balloon injury in porcine coronary arteries. (2012)
  • Author(s): Egashira K
  • Organizer: The 4th Oriental Congress of Cardiology & The 5th AICT
  • Place of Presentation: Shanghai
  • Invited
• [Presentation] Nanotechnology-Based DDS for Patients with Critical Limb Ischemia. (2012)
  • Author(s): Egashira K
  • Organizer: The 2012 Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis
  • Place of Presentation: Taipei
  • Invited
• [Presentation] ナノテクノロジーを基盤とする動脈硬化プラーク破綻と虚血－再灌流傷害に対する新しい治療法の開発 (2012)
  • Author(s): 江頭健輔
  • Organizer: 第44回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] ナノテクノロジーを用いたdrug delivery system（ナノDDS）による心血管病に対する革新的治療実用化 (2012)
  • Author(s): 江頭健輔
  • Organizer: 第32回日本川崎病学会・学術集会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Nanotechnology-based endothelial cell selective DDS for therapeutic neovascularization (2011)
  • Author(s): Egashira K
  • Organizer: The Second Pacific Symposium on Vascular Biology (Invited lecture)
  • Place of Presentation: THE SHILLA JEJU, 韓国
  • Year and Date: 2011-11-01
• [Presentation] Nanotechnology-based endothelial cell selective DDS for therapeutic neovascularization (2011)
  • Author(s): Egashira K
  • Organizer: The Second Pacific Symposium on Vascular Biology
  • Place of Presentation: Jeju Island, Korea(Invited lecture)(招待講演)
  • Year and Date: 2011-11-01
• [Presentation] ナノテクノロジーを基盤とする新しい治療的血管新生療法と心筋保護-日本初の独創的なナノ治療の実用化を目指して- (2011)
  • Author(s): 江頭健輔
  • Organizer: The12th Vascularand Brain Conference21世紀における血管病治療の新展開
  • Place of Presentation: 帝国ホテル大阪
  • Year and Date: 2011-09-30
• [Presentation] ナノテクノロジーを基盤とする新しい治療的血管新生療法と心筋保護-日本初の独創的なナノ治療の実用化を目指して- (2011)
  • Author(s): 江頭健輔
  • Organizer: The 12th Vascular and Brain Conference 21世紀における血管病治療の新展開
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-09-30
• [Presentation] A New Therapeutic Modality for Ischemia-Reperfusion Injury: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduced Ischemia/Reperfusion Injury in Rats (2011)
  • Author(s): Egashira K
  • Organizer: The Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis 2011 and The llth Taipei International Vascular Biology Symposium
  • Place of Presentation: 振興醫療財團法人振興醫院第二醫療大樓5樓、台湾
  • Year and Date: 2011-09-18
• [Presentation] A New Therapeutic Modality for Ischemia-Reperfusion Injury : Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduced Ischemia/Reperfusion Injury in Rats (2011)
  • Author(s): Egashira K
  • Organizer: The Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis 2011 and The 11th Taipei International Vascular Biology Symposium
  • Place of Presentation: Taipei, Taiwan(Invited lecture)(招待講演)
  • Year and Date: 2011-09-18
• [Presentation] Impact of nanotechnology-based endothelial cell-selective delivery of pitavastatin for therapeutic arteriogenesis in critical limb ischemia (2011)
  • Author(s): Egashira K
  • Organizer: The 9th Japan-Korea Joint Symposium on Vascular Biology (Symposium)
  • Place of Presentation: The Westin Chosun Busan, Q
  • Year and Date: 2011-08-25
• [Presentation] Impact of nanotechnology based endothelial cell-selective delivery of pitavastatin for therapeutic arteriogenesis in critical limb ischemia (2011)
  • Author(s): Egashira K
  • Organizer: The 9th Japan-Korea Joint Symposium on Vascular Biology
  • Place of Presentation: Busan, Korea(Symposium)(招待講演)
  • Year and Date: 2011-08-25
• [Presentation] New evidences: Phase IV trials and ongoiog & future studies with pitavastatin (2011)
  • Author(s): Egashira K
  • Organizer: New evidences: Phase IV trials and ongoiog & future studies with pitavastatin (Invited lecture)
  • Place of Presentation: CCIB- CENTRO DE CONVENCIONES INTERNACIONALES DE BARCELONA, . -(スペイン)
  • Year and Date: 2011-05-13
• [Presentation] New evidences : Phase IV trials and ongoiog & future studies with pitavastatin (2011)
  • Author(s): Egashira K
  • Organizer: New evidences : Phase IV trials and ongoiog & future studies with pitavastatin
  • Place of Presentation: Varcelona, Spain(招待講演)(Invited lecture)
  • Year and Date: 2011-05-13
• [Presentation] lmpact of Nanotechnology-based Drag Delivery on Treatment of Cardiovascular Disease (2010)
  • Author(s): Egashira K
  • Organizer: The Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis 2010 and The 10th Taipei International Vascular Biology Symposium
  • Place of Presentation: 振興醫療 財團法人振興醫院第二醫療大樓6樓國際 會議廳、台湾
  • Year and Date: 2010-08-15
• [Presentation] Impact of Nanotechnology-based Drag Delivery on Treatment of Cardiovascular Disease (2010)
  • Author(s): Egashira K
  • Organizer: The Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis 2010 and The 10th Taipei International Vascular Biology Symposium
  • Place of Presentation: Taipei
  • Year and Date: 2010-08-15
• [Presentation] A new treatment for CAD: Nanotechnology-based Arteriogenesis and Angiogenesis (2010)
  • Author(s): Egashira K
  • Organizer: The 4th Oriental Congress of Cardiology & The 5th AICT
  • Place of Presentation: 上海国際会議中心、中国
  • Year and Date: 2010-05-30
• [Presentation] A new treatment for CAD : Nanotechnology-based Arteriogenesis and Angiogenesis. (2010)
  • Author(s): Egashira K
  • Organizer: The 4th Oriental Congress of Cardiology & The 5th AICT
  • Place of Presentation: Shanghai
  • Year and Date: 2010-05-30
• [Presentation] 血管内皮細胞選択的ナノDDS技術」を基盤とする革新的低侵襲治療的血管新生療法の実現のための橋渡し研究 (2010)
  • Author(s): 江頭健輔
  • Organizer: 第32回ヒューマンサイエンスバイオインターフェースー創薬のための知的相互交流一
  • Place of Presentation: 全理連ビル
  • Year and Date: 2010-05-19
• [Presentation] 血管内皮細胞選択的ナノDDS技術」を基盤とする革新的低侵襲治療的血管新生療法の実現のための橋渡し研究 (2010)
  • Author(s): 江頭健輔
  • Organizer: 第32回ヒューマンサイエンス バイオインターフェース-創薬のための知的相互交流-
  • Place of Presentation: 東京
  • Year and Date: 2010-05-19
• [Presentation] Impact of nanotechnology-based selective delivery of pitavastatin for the development of innovative treatment of ischemic cardiovascular diseases (2010)
  • Author(s): Egashira K
  • Organizer: 7th Metabolic Syndrome, Type II Diabetes and Atherosclerosis Congress
  • Place of Presentation: La Salle desAmbassadeurs、モロッコ
  • Year and Date: 2010-05-14
• [Presentation] Impact of nanotechnology-based selective delivery of pitavastatin for the development of innovative treatment of ischemic cardiovascular diseases. (2010)
  • Author(s): Egashira K
  • Organizer: 7th Metabolic Syndrome, Type II Diabetes and Atherosclerosis Congress
  • Place of Presentation: Morocco
  • Year and Date: 2010-05-14
• [Book] ナノテクノロジー血管生物医学事典 (2011)
  • Author(s): 江頭健輔、的場哲哉
  • Publisher: 血管生物医学会
• [Book] 血管生物医学事典 (2011)
  • Author(s): 江頭健輔, 他
  • Total Pages: 2
  • Publisher: 血管生物医学会
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/1_sentaniryo/
• [Remarks] 循環器病先端医療研究開発学講座
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/1_sentaniryo/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/1_sentaniryo/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/
• [Patent(Industrial Property Rights)] スタチン封入ナノ粒子含有医薬組成物 (2011)
  • Inventor(s): 江頭健輔
  • Industrial Property Rights Holder: 江頭健輔、九州大学
  • Acquisition Date: 2011-12-09
• [Patent(Industrial Property Rights)] 下肢虚血モデル動物 (2010)
  • Inventor(s): 江頭健輔
  • Industrial Property Rights Holder: 興和(株)
  • Industrial Property Number: 2010-279358
  • Filing Date: 2010-12-15