| Project/Area Number |
22390178
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
KIRA Jun-ichi 九州大学, 医学研究院, 教授 (40183305)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Takuya 九州大学, 医学研究院, 学術研究員 (00533001)
KAWAMURA Nobutoshi 九州大学, 医学研究院, 共同研究員 (00432930)
KAWANO Yuji 九州大学, 大学病院, 講師 (20333479)
YOSHIMURA Satoshi 九州大学, 大学病院, 共同研究員 (20596390)
三野原 元澄 九州大学, 大学病院, 特任講師 (70398113)
土井 光 九州大学, 大学病院, 助教 (30423552)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 多発性硬化症 / 遺伝子間相互作用 / サイトカイン / 自己抗体 / 視神経脊髄炎 / HLA / IL2RA / 自己抗体プロファイル / バイオマーカー / IL7RA |
|---|
| Research Abstract |
In Japanese demyelinating disease, whereas DRB1*0901 is a disease resi stance gene regardless of the disease phenotype, disease susceptibility gene revealed that depending on the disease phenotype. IL7RA gene, a disease susceptibility gene in Western Caucasian, was shown to be a disease susceptibility gene in Japanese MS. The IL2RA gene, may contribute to disease susceptibility only when it interacts with HLA-DRB1*1501 or HLA-DRB1*0405. By using a cell-free protein synthesis system, LUZP1 is obtained as a self-antigen significantly more in CIDP than Balo disease, SOX6 was obtained as a self-antigen significantly more in MS than Balo disease and CIDP. The high sensitivity anti-AQP4 antibody assay revealed that IgG1 is associated with disease duration, and there was a reverse correlation between the spinal cord lesion length IgG2 .
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