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Identification of the pathogenesis of nephrotic syndrome by analyses of signal transduction and proteome

Research Project

Project/Area Number 22390204
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research Institution独立行政法人国立成育医療研究センター (2012)
The University of Tokyo (2010-2011)

Principal Investigator

IGARASHI Takashi  独立行政法人国立成育医療研究センター, 総長 (70151256)

Co-Investigator(Kenkyū-buntansha) HATTORI Seisuke  北里大学, 薬学部, 教授 (50143508)
HARITA Yutaka  東京大学, 医学部付属病院, 講師 (10451866)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords小児腎 / 泌尿器学 / 腎臓 / 蛋白尿 / 糸球体上皮細胞 / Nephrin / MYH9 / プロテオミクス / TRPC6 / PLC-γ1
Research Abstract

Slit diaphragm, an intercellular junction between renal glomerular epithelial cells (podocytes), is essential for the permselectivity in glomerular ultrafiltarion. To establish specific therapy for pediatric nephrotic syndrome, we focused on the structure and function of slit diaphragm (SD) and investigated the pathogenic mechanism of proteinuria and nephrotic syndrome. We revealed (I) the importance of dynamics of slit diaphragm turnover in the maintenance of slit diaphragm, (II) the novel component of slit diaphragm, (III) the mechanism of intracellular calcium concentration by slit diaphragm signaling, and (IV) the changes of expression of functional proteins in podocytes of nephrotic patients. Our data provide new molecular insights into the formation and maintenance of SD and its dysfunction in hereditary and idiopathic nephrotic syndrome.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (72 results)

All 2012 2011 2010 Other

All Journal Article (40 results) (of which Peer Reviewed: 6 results) Presentation (28 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlights protean agonism of V2R antagosists2012

    • Author(s)
      Takahashi K, Makita N, Manaka K, et al.
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 2099-2106

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Early occurrence of nephrotic syndrome associated with cord blood stem cell transplantation.2012

    • Author(s)
      Miura K, Sekine T, Takamizawa M, et al.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 16 Pages: 180-182

    • Related Report
      2012 Annual Research Report
  • [Journal Article] SIRPα interacts with nephrin at the podocyte slit diaphragm2012

    • Author(s)
      Kajiho Y, Harita Y, Kurihara H, et al.
    • Journal Title

      FEBS J.

      Volume: 279 Pages: 3010-21

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Clinical characteristics of obstructive uropthy associated with rotavirus gastroenteritis in Japan.2012

    • Author(s)
      Ashida A, Fujieda M, Ohta K, et al.
    • Journal Title

      Clin. Nephrol.

      Volume: 77 Pages: 49-54

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 遺伝性腎尿路疾患の原因遺伝子リスト 最新版2012

    • Author(s)
      五十嵐隆
    • Journal Title

      小児内科

      Volume: 44 Pages: 324-327

    • Related Report
      2012 Annual Research Report
  • [Journal Article] コンピュータを用いた分子構造解析によるDent病におけるClC-5蛋白の機能予測2012

    • Author(s)
      芦田明、山本大助、白数明彦、中倉兵庫、松村英樹、関根孝司、五十嵐隆、玉井浩
    • Journal Title

      発達腎研究会誌

      Volume: 20 Pages: 10-12

    • Related Report
      2012 Annual Research Report
  • [Journal Article] ADH不適切分泌症候群(SIADH)2012

    • Author(s)
      張田豊
    • Journal Title

      小児内科

      Volume: 44 Pages: 118-119

    • Related Report
      2012 Annual Research Report
  • [Journal Article] プロテオミクスースリット膜リン酸化シグナルの解析2012

    • Author(s)
      張田豊
    • Journal Title

      腎と透析

      Volume: 72 Pages: 221-226

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 発症メカニズム 糸球体蛋白—糸球体上皮細胞とその関連蛋白2012

    • Author(s)
      張田豊
    • Journal Title

      小児内科

      Volume: 44 Pages: 174-177

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Tyrosine kinase signaling in kidney glomerular podocytes.2011

    • Author(s)
      Hattori S, Kanda S, Harita Y
    • Journal Title

      Signal Transduct

      Volume: 2011 Pages: 31785-31785

    • Related Report
      2012 Final Research Report
  • [Journal Article] Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC_<-γ>1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis.2011

    • Author(s)
      Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T, Hattori S
    • Journal Title

      Mol Biol Cell

      Volume: 22 Pages: 1824-351

    • Related Report
      2012 Final Research Report
  • [Journal Article] Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue.2011

    • Author(s)
      Hirata Y, Tabata M, Kurobe H, Motoki T, Akaike M, Nishio C, Higashida M, Mikasa H, Nakaya Y, Takanashi S, Igarashi T, Kitagawa T, Sata M
    • Journal Title

      Am Coll Cardiol

      Volume: 58 Pages: 248-255

    • Related Report
      2012 Final Research Report
  • [Journal Article] A synthetic prostacyclin agonist, ONO-1301, ameliorates ventricular remodeling after acute myocardial infarction via upregulation of HGF in rat.2011

    • Author(s)
      Hirata Y, Soekia T, Yamadaa H, Shiotac A, Shimabukuroc M, Sakaid Y, Nakayamae M, Matsumotoe K, Igarashi T, Sata M
    • Journal Title

      Biomedicine & Aging Pathology

      Volume: 1 Pages: 90-96

    • Related Report
      2012 Final Research Report
  • [Journal Article] Increased Akt-mTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice.2011

    • Author(s)
      Ikeda H, Shiojima I, Oka T, Yoshida M, Maemura K, Walsh K, Igarashi T, Komuro I
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 1054-1065

    • Related Report
      2012 Final Research Report
  • [Journal Article] Congenital infection-like syndrome with intaracranial calcification.2011

    • Author(s)
      Mizuno Y, Takahashi K, Igarashi T, Saito M, Mizuguchi M
    • Journal Title

      Brain & Develop

      Volume: 33 Pages: 530-533

    • Related Report
      2012 Final Research Report
  • [Journal Article] Model combining hydrodynamics and fractal theory for analysis of in vivo peropheral pulmonary and systemic resistance of shunt cardiac defects.2011

    • Author(s)
      Nakamura Y, Awa S, Kato H, Ito YM, Kamiya A, Igarashi T
    • Journal Title

      J Theoret Biology

      Volume: 287 Pages: 64-73

    • Related Report
      2012 Final Research Report
  • [Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies.2011

    • Author(s)
      Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Okubo J, Adachi M, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S
    • Journal Title

      Leukemia

      Volume: 25 Pages: 1-3

    • Related Report
      2012 Final Research Report
  • [Journal Article] nterstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma.2011

    • Author(s)
      Takahashi K, Oka A, Mizuguchi M, Saitoh M, Takita J, Sato A, Mimaki M, Kato M, Ogawa S, Igarashi T
    • Journal Title

      Brain & Develop

      Volume: 33 Pages: 353-356

    • Related Report
      2012 Final Research Report
  • [Journal Article] Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma.2011

    • Author(s)
      Takita J, Chen Y, Sanada M, Adachi M, Ohki K, Nishimura R, Hanada R, Igarashi T, Hayashi Y, Ogawa S
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 1645-1650

    • Related Report
      2012 Final Research Report
  • [Journal Article] VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells.2011

    • Author(s)
      Shirakabe K, Hattori S, Seiki M, Koyasu S, Okada Y
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 43154-43163

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches.2011

    • Author(s)
      Katsumata Y, Kawaguchi Y, Baba S, Hattori S, Tahara K, Ito K, Iwasaki T, Yamaguchi N, Oyama M, Kozuka-Hata H, Hattori H, Nagata K, Yamanaka H, Hara M
    • Journal Title

      Mol Cell Proteomics

      Volume: 10

    • Related Report
      2012 Final Research Report
  • [Journal Article] Tyrosine phosphorylation dependent activation of TRPC6 regulated by PLC-g1 and Nephrin : Effect of mutations associated with focal glomerulosclerosis2011

    • Author(s)
      Kanda S, Harita Y, Igarashi T, et al
    • Journal Title

      Molecular Biology of the Cell

      Volume: 22 Pages: 1824-1835

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caシグナル異常によるPodocyte傷害メカニズムー新たな蛋白尿治療の開発に向けて2011

    • Author(s)
      神田祥一郎、張田豊
    • Journal Title

      日本小児腎臓病学会雑誌

      Volume: 24 Pages: 13-23

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ネフローゼ症候群と糸球体上皮細胞2011

    • Author(s)
      張田豊
    • Journal Title

      総合臨床

      Volume: 60 Pages: 781-782

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Tyrosine kinase signaling in kidney glomerular podocyte2011

    • Author(s)
      Hattori S, Kanda S, Harita Y
    • Journal Title

      Journal of Signal Transduction

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyrosine phosphorylation dependent activation of TRPC6 regulated by PLC-g1 and Nephrin : Effect of mutations associated with focal glomerulosclesoris.2011

    • Author(s)
      Kanda S, Harita Y, Shibagaki Y, et al.
    • Journal Title

      Molecular Biology of the Cell

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney.2010

    • Author(s)
      Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25 Pages: 1785-95

    • Related Report
      2012 Final Research Report
  • [Journal Article] Renal manifestations, progression and pathological findings in patients with R702 mutations in MYH9.2010

    • Author(s)
      SekineT, Konno M, Sasaki S, Moritani Sm Miura T, Wong WS, Nishio H Nishiguchi T, Yoshinari M, Tsuchiya S, Matsuyama T, Kanegane H, Ida K, Miura K, Harita Y, Igarashi T, Hattori M, Horita S, Saito H, Kunishima S
    • Journal Title

      Kidney Int.

      Volume: 8 Pages: 207-14

    • Related Report
      2012 Final Research Report
  • [Journal Article] ASPP2 regulates epithelial cell polarity through the PAR complex.2010

    • Author(s)
      Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, Ohno S
    • Journal Title

      Curr Biol.

      Volume: 20 Pages: 1408-14

    • Related Report
      2012 Final Research Report
  • [Journal Article] SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulus.2010

    • Author(s)
      Kurihara H, Harita Y, Ichimura K, Hattori S, Sakai T
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2012 Final Research Report
  • [Journal Article] Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection.2010

    • Author(s)
      Morita T, Ashida A, Fujieda A, Hayashi A, Meda A, Ohta K, Shimizu M, Sekine T, Igarashi T, Tamai H, Wakiguchi H
    • Journal Title

      Clin Nephrol

      Volume: 73 Pages: 398-402

    • Related Report
      2012 Final Research Report
  • [Journal Article] Case report: Prenatal intervention for severe anterior urethral valve.2010

    • Author(s)
      Mizuno Y, Tsuchida S, Kakiuchi S, Ishiguro A, Goishi K, Kamei Y, Kanamori Y, Yamazaki Y, Sekine T, Igarashi T
    • Journal Title

      Pediatr Inter

      Volume: 52

    • Related Report
      2012 Final Research Report
  • [Journal Article] Patients with Epstein-Fechtner syndrome owing to MYH9 R702 mutations develop progressive proteinuric renal disease.2010

    • Author(s)
      Sekine T, Konno M, Sasaki S, Moritani S, Miura T, Wong WS, Nishio H, Nishiguchi T, Ohuchi MY, Tsuchiya S, Matsuyama T, Kanegane H, Ida K, Miura K, Harita Y, Hattori M, Horita S, Igarashi T, Saito H, Kunishima S
    • Journal Title

      Kidney Int

      Volume: 78 Pages: 207-214

    • Related Report
      2012 Final Research Report
  • [Journal Article] Skin and subcutaneous blood flows of very low birth weight infants during the first 3 postnatal days.2010

    • Author(s)
      Ishiguro A, Sekine T, Kakiuchi S, Nishimura R, Goishi K, Tsuchida S, Ohtsu H, Igarashi T
    • Journal Title

      J Matern Fetal Neonatal Med

      Volume: 23 Pages: 522-528

    • Related Report
      2012 Final Research Report
  • [Journal Article] Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection2010

    • Author(s)
      Morita T, Ashida A, Fujieda M, Hayash A, Maeda A, Ohta K, Shimizu M, Sekine T, Igarashi T, Tamai H, Wakiguchi H
    • Journal Title

      Clinical Nephrol

      Volume: 73 Pages: 398-402

    • Related Report
      2012 Final Research Report
  • [Journal Article] Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease.2010

    • Author(s)
      Sekine T, Konno M, Sasaki S, Moritani S, Miura T, Wong WS, Nishio H, Nishiguchi T, Ohuchi MY, Tsuchiya S, Matsuyama T, Kanegane H, Ida K, Miura K, Harita Y, Hattori M, Horita S, Igarashi T, Saito H, Kunishima S
    • Journal Title

      Kidney Int

      Volume: 78 Pages: 207-214

    • Related Report
      2012 Final Research Report
  • [Journal Article] Defective membrane expression of the Na+-HCO3- cotransporter NBCe1 is associated with familial migraine.2010

    • Author(s)
      Suzuki M, Paesschen WV, Stalmans I, Horita S, Yamada H, Bergmans BA, Legius E, Riant F, Jonghe PD, Li Y, Sekine T, Igarashi T, Fujimoto I, Mikoshiba K, Shimadzu M, Shohara M, Braverman N, Al-Gazali L, Fujita T, Seki J
    • Journal Title

      Pnas

      Volume: 107 Pages: 15963-15968

    • Related Report
      2012 Final Research Report
  • [Journal Article] Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling.2010

    • Author(s)
      Tasaki S, Nagasaki M, Kozuka-Hata H, Semba K, Gotoh N, Hattori S, Inoue J, Yamamoto T, Miyano S, Sugano S, Oyama M
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2012 Final Research Report
  • [Journal Article] SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulus.2010

    • Author(s)
      Kurihara H, Harita Y, Ichimura K, et al.
    • Journal Title

      American Journal of Physiology. Renal Physiology

      Volume: 299 Pages: 517-527

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASPP2 regulates epithelial cell polarity through the PAR complex.2010

    • Author(s)
      Cong W, Hirose T, Harita Y, et al.
    • Journal Title

      Current Biology

      Volume: 20 Pages: 1408-1414

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] スリット膜複合体のターンオーバーを制御するメカニズム2012

    • Author(s)
      張田豊
    • Organizer
      第7回弥彦ポドサイトセミナー
    • Place of Presentation
      新潟(招待講演)
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Toward the practical use of nephrin peptides as a TRPC6 inhibitor2011

    • Author(s)
      Kaada S, Harita Y, Igarashi T, et al
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      米国、Philadelphia
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛋白尿-ポドサイトロジーが迫るその本質-2011

    • Author(s)
      張田豊
    • Organizer
      第17回Rokko Nephrology Research Forum
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2011-10-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 限外濾過膜としてのスリット膜のターンオーバーのメカニズム2011

    • Author(s)
      佐藤大輔、張田豊, 他
    • Organizer
      第100回東京腎生理集談会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロテオミクス:スリット膜リン酸化シグナルの解析2011

    • Author(s)
      張田豊
    • Organizer
      第33回腎臓セミナー
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-08-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛋白尿の分子メカニズム2011

    • Author(s)
      張田豊
    • Organizer
      第11回静岡小児腎臓病学術講演会
    • Place of Presentation
      焼津(招待講演)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] スリット膜のターンオーバー制御を担う分子機構の解明2011

    • Author(s)
      佐藤大輔、張田豊, 他
    • Organizer
      第54回日本腎臓学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanism regulating the turnover of nephiin2011

    • Author(s)
      Sato D, Harita Y, Igarashi T, et al
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of TRPC6 inhibitor-antagonistic role of nephrin peptide on TRPC6 activation-2011

    • Author(s)
      Kanda S, Harita Y, Igarashi T, et al
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] ネフローゼ発症におけるTRPC6活性化メカニズム2010

    • Author(s)
      神田祥一郎、張田豊、五十嵐隆, 他
    • Organizer
      第1回分子腎臓フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of the tyrosine phosphorylation of TRPC6 in proteinuric kidney diseases2010

    • Author(s)
      Kanda S, Harita Y, Sekine T, et al.
    • Organizer
      The 15th congress of the International Pediatric Nephrology Association
    • Place of Presentation
      New York, USA
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Podocyte Signal Transduction2010

    • Author(s)
      Harita Y
    • Organizer
      Congress of International Pediatric Nephrology Association
    • Place of Presentation
      New York, USA
    • Year and Date
      2010-08-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] ネフローゼ症候群発症におけるTRPC6活性化メカニズム2010

    • Author(s)
      神田祥一郎、張田豊、関根孝司, 他
    • Organizer
      第45回日本小児腎臓病学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規スリット膜構成分子SIRP-alphaはNephrinと結合し、そのリン酸化を負に制御する2010

    • Author(s)
      張田豊、松長敦子、鶴見晴子, 他
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] ネフローゼ症候群発症におけるTRPC6活性化メカニズムの解析2010

    • Author(s)
      神田祥一郎、張田豊、関根孝司, 他
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] The regulatory mechanism of TRPC6 activation by FSGS-causing mutations2010

    • Author(s)
      Kanda S, Harita Y, Sekine T, et al.
    • Organizer
      Korea-Japan The 8th Pediatric Nephrology Seminar
    • Place of Presentation
      慶州,韓国
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Phosphorylation-mediated signaling in glomerular podocyte and its implication in the pathogenesis of proteinuria2010

    • Author(s)
      Harita Y, Kanda S, Sekine T, et al.
    • Organizer
      Pediatric Academic Societies Annual Meeting
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-05-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Phosphorylation-dependent membrane insertion and activation of TRPC6 is regulated by a balance between Nephrin and PLC-γ12010

    • Author(s)
      Kanda S, Harita Y, Sekine T, et al.
    • Organizer
      6^<th> Asian Society for Pediatric Research
    • Place of Presentation
      Taipei,台湾
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epithelial Protein Lost in Neoplasm (EPLIN) Regulates Actin Dynamics and Motility of Glomerular Mesangial Cells.

    • Author(s)
      Tsurumi H, Harita Y, Miura K, and Igarashi T.
    • Organizer
      Pediatric Academic Societies Annual Meeting,
    • Place of Presentation
      Boston, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Composition of slit diaphragm complex in congenital nephritic syndrome.

    • Author(s)
      Kajiho Y, Harita Y, Tsurumi H, Miura K, Hattori M, and Igarashi T
    • Organizer
      8th congress of Asian Society of Pediatric Research
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Epithelial protein lost in neoplasm (EPLIN) regulates actin dynamics and motility of glomerular mesangial cells.

    • Author(s)
      Tsurumi H, Harita Y, Kajiho Y, Kanda S, Miura K, Sekine T, Hattori M, Igarashi T
    • Organizer
      8th congress of Asian Society of Pediatric Research
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Epithelial protein lost in neoplasm (EPLIN) interacts with paxillin and regulates mesangial migration.

    • Author(s)
      Tsurumi H, Harita Y, Kajiho Y, Kanda S, Miura K, Sekine T, Hattori M, Igarashi T
    • Organizer
      ASN Kidney Week
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 特別企画 FSGSの移植後再発のメカニズム

    • Author(s)
      張田豊、石塚喜代伸
    • Organizer
      第47回 小児腎臓病学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 蛋白尿の発症機序(シンポジウム)

    • Author(s)
      張田豊
    • Organizer
      第115回 小児科学会学術講演会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 先天性ネフローゼ症候群におけるスリット膜複合体形成

    • Author(s)
      梶保祐子、張田豊、鶴見晴子、三浦健一郎、五十嵐隆
    • Organizer
      第55回 日本腎臓学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] EPLIN(Epithelial protein lost in neoplasm)はアクチン細胞骨格を介してメサンギウム細胞の運動性を制御する

    • Author(s)
      鶴見晴子、張田豊、栗原秀剛、神田祥一郎、三浦健一郎、梶保祐子、関根孝司、服部成介、服部元史、五十嵐隆
    • Organizer
      第55回 日本腎臓学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] RacGAP因子FilGAPはAfadinと結合し、腎糸球体上皮細胞におけるアクチン細胞骨格形成を制御する。

    • Author(s)
      椎野 達大, 斉藤 康二, 望月 優加, 栗原 秀剛, 張田 豊, 柴垣 芳夫, 服部 成介, 太田 安隆
    • Organizer
      35回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] メサンギウム細胞の運動性を制御するメカニズムーアクチン結合蛋白質EPLIN(Epithelial protein lost in neoplasm)の役割—

    • Author(s)
      鶴見晴子、張田豊、栗原秀剛、神田祥一郎、三浦健一郎、梶保祐子、関根孝司、服部成介、服部元史、五十嵐隆
    • Organizer
      第47回 小児腎臓病学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] 小児腎疾患の臨床(改訂第5版)2012

    • Author(s)
      五十嵐隆
    • Total Pages
      310
    • Publisher
      診断と治療社
    • Related Report
      2011 Annual Research Report
  • [Book] 小児腎疾患の臨床改訂第4版2010

    • Author(s)
      五十嵐隆
    • Total Pages
      332
    • Publisher
      診断と治療社
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] ポリペプチド2010

    • Inventor(s)
      神田祥一郎、張田豊、服部成介、五十嵐隆、井上貴文
    • Industrial Property Rights Holder
      国立大学法人東京大学,学校法人北里研究所,学校法人早稲田大学
    • Acquisition Date
      2010-08-03
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ポリペプチド2010

    • Inventor(s)
      神田祥一郎、張田豊, 服部成介, 五十嵐隆, 井上貴文
    • Industrial Property Rights Holder
      東京大学, 北里研究所, 早稲田大学
    • Industrial Property Number
      2010-174155
    • Filing Date
      2010-08-03
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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