Identification of the pathogenesis of nephrotic syndrome by analyses of signal transduction and proteome

• Project/Area Number: 22390204
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: 独立行政法人国立成育医療研究センター (2012); The University of Tokyo (2010-2011)
• Principal Investigator: IGARASHI Takashi 独立行政法人国立成育医療研究センター, 総長 (70151256)
• Co-Investigator(Kenkyū-buntansha): HATTORI Seisuke 北里大学, 薬学部, 教授 (50143508) ; HARITA Yutaka 東京大学, 医学部付属病院, 講師 (10451866)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 小児腎 / 泌尿器学 / 腎臓 / 蛋白尿 / 糸球体上皮細胞 / Nephrin / MYH9 / プロテオミクス / TRPC6 / PLC-γ1

Research Abstract

Slit diaphragm, an intercellular junction between renal glomerular epithelial cells (podocytes), is essential for the permselectivity in glomerular ultrafiltarion. To establish specific therapy for pediatric nephrotic syndrome, we focused on the structure and function of slit diaphragm (SD) and investigated the pathogenic mechanism of proteinuria and nephrotic syndrome. We revealed (I) the importance of dynamics of slit diaphragm turnover in the maintenance of slit diaphragm, (II) the novel component of slit diaphragm, (III) the mechanism of intracellular calcium concentration by slit diaphragm signaling, and (IV) the changes of expression of functional proteins in podocytes of nephrotic patients. Our data provide new molecular insights into the formation and maintenance of SD and its dysfunction in hereditary and idiopathic nephrotic syndrome.

Research Products

• [Journal Article] V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlights protean agonism of V2R antagosists (2012)
  • Author(s): Takahashi K, Makita N, Manaka K, et al.
  • Journal Title: J Biol Chem Volume: 287 Pages: 2099-2106
• [Journal Article] Early occurrence of nephrotic syndrome associated with cord blood stem cell transplantation. (2012)
  • Author(s): Miura K, Sekine T, Takamizawa M, et al.
  • Journal Title: Clin Exp Nephrol. Volume: 16 Pages: 180-182
• [Journal Article] SIRPα interacts with nephrin at the podocyte slit diaphragm (2012)
  • Author(s): Kajiho Y, Harita Y, Kurihara H, et al.
  • Journal Title: FEBS J. Volume: 279 Pages: 3010-21
• [Journal Article] Clinical characteristics of obstructive uropthy associated with rotavirus gastroenteritis in Japan. (2012)
  • Author(s): Ashida A, Fujieda M, Ohta K, et al.
  • Journal Title: Clin. Nephrol. Volume: 77 Pages: 49-54
• [Journal Article] 遺伝性腎尿路疾患の原因遺伝子リスト 最新版 (2012)
  • Author(s): 五十嵐隆
  • Journal Title: 小児内科 Volume: 44 Pages: 324-327
• [Journal Article] コンピュータを用いた分子構造解析によるDent病におけるClC-5蛋白の機能予測 (2012)
  • Author(s): 芦田明、山本大助、白数明彦、中倉兵庫、松村英樹、関根孝司、五十嵐隆、玉井浩
  • Journal Title: 発達腎研究会誌 Volume: 20 Pages: 10-12
• [Journal Article] ADH不適切分泌症候群(SIADH) (2012)
  • Author(s): 張田豊
  • Journal Title: 小児内科 Volume: 44 Pages: 118-119
• [Journal Article] プロテオミクスースリット膜リン酸化シグナルの解析 (2012)
  • Author(s): 張田豊
  • Journal Title: 腎と透析 Volume: 72 Pages: 221-226
• [Journal Article] 発症メカニズム 糸球体蛋白—糸球体上皮細胞とその関連蛋白 (2012)
  • Author(s): 張田豊
  • Journal Title: 小児内科 Volume: 44 Pages: 174-177
• [Journal Article] Tyrosine kinase signaling in kidney glomerular podocytes. (2011)
  • Author(s): Hattori S, Kanda S, Harita Y
  • Journal Title: Signal Transduct Volume: 2011 Pages: 31785-31785
• [Journal Article] Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC_<-γ>1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis. (2011)
  • Author(s): Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T, Hattori S
  • Journal Title: Mol Biol Cell Volume: 22 Pages: 1824-351
• [Journal Article] Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. (2011)
  • Author(s): Hirata Y, Tabata M, Kurobe H, Motoki T, Akaike M, Nishio C, Higashida M, Mikasa H, Nakaya Y, Takanashi S, Igarashi T, Kitagawa T, Sata M
  • Journal Title: Am Coll Cardiol Volume: 58 Pages: 248-255
• [Journal Article] A synthetic prostacyclin agonist, ONO-1301, ameliorates ventricular remodeling after acute myocardial infarction via upregulation of HGF in rat. (2011)
  • Author(s): Hirata Y, Soekia T, Yamadaa H, Shiotac A, Shimabukuroc M, Sakaid Y, Nakayamae M, Matsumotoe K, Igarashi T, Sata M
  • Journal Title: Biomedicine & Aging Pathology Volume: 1 Pages: 90-96
• [Journal Article] Increased Akt-mTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice. (2011)
  • Author(s): Ikeda H, Shiojima I, Oka T, Yoshida M, Maemura K, Walsh K, Igarashi T, Komuro I
  • Journal Title: Mol Cell Biol Volume: 31 Pages: 1054-1065
• [Journal Article] Congenital infection-like syndrome with intaracranial calcification. (2011)
  • Author(s): Mizuno Y, Takahashi K, Igarashi T, Saito M, Mizuguchi M
  • Journal Title: Brain & Develop Volume: 33 Pages: 530-533
• [Journal Article] Model combining hydrodynamics and fractal theory for analysis of in vivo peropheral pulmonary and systemic resistance of shunt cardiac defects. (2011)
  • Author(s): Nakamura Y, Awa S, Kato H, Ito YM, Kamiya A, Igarashi T
  • Journal Title: J Theoret Biology Volume: 287 Pages: 64-73
• [Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies. (2011)
  • Author(s): Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Okubo J, Adachi M, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S
  • Journal Title: Leukemia Volume: 25 Pages: 1-3
• [Journal Article] nterstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma. (2011)
  • Author(s): Takahashi K, Oka A, Mizuguchi M, Saitoh M, Takita J, Sato A, Mimaki M, Kato M, Ogawa S, Igarashi T
  • Journal Title: Brain & Develop Volume: 33 Pages: 353-356
• [Journal Article] Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma. (2011)
  • Author(s): Takita J, Chen Y, Sanada M, Adachi M, Ohki K, Nishimura R, Hanada R, Igarashi T, Hayashi Y, Ogawa S
  • Journal Title: Cancer Science Volume: 102 Pages: 1645-1650
• [Journal Article] VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells. (2011)
  • Author(s): Shirakabe K, Hattori S, Seiki M, Koyasu S, Okada Y
  • Journal Title: J Biol Chem Volume: 286 Pages: 43154-43163
• [Journal Article] Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches. (2011)
  • Author(s): Katsumata Y, Kawaguchi Y, Baba S, Hattori S, Tahara K, Ito K, Iwasaki T, Yamaguchi N, Oyama M, Kozuka-Hata H, Hattori H, Nagata K, Yamanaka H, Hara M
  • Journal Title: Mol Cell Proteomics Volume: 10
• [Journal Article] Tyrosine phosphorylation dependent activation of TRPC6 regulated by PLC-g1 and Nephrin : Effect of mutations associated with focal glomerulosclerosis (2011)
  • Author(s): Kanda S, Harita Y, Igarashi T, et al
  • Journal Title: Molecular Biology of the Cell Volume: 22 Pages: 1824-1835
  • Peer Reviewed
• [Journal Article] Caシグナル異常によるPodocyte傷害メカニズムー新たな蛋白尿治療の開発に向けて (2011)
  • Author(s): 神田祥一郎、張田豊
  • Journal Title: 日本小児腎臓病学会雑誌 Volume: 24 Pages: 13-23
  • Peer Reviewed
• [Journal Article] ネフローゼ症候群と糸球体上皮細胞 (2011)
  • Author(s): 張田豊
  • Journal Title: 総合臨床 Volume: 60 Pages: 781-782
• [Journal Article] Tyrosine kinase signaling in kidney glomerular podocyte (2011)
  • Author(s): Hattori S, Kanda S, Harita Y
  • Journal Title: Journal of Signal Transduction
  • Peer Reviewed
• [Journal Article] Tyrosine phosphorylation dependent activation of TRPC6 regulated by PLC-g1 and Nephrin : Effect of mutations associated with focal glomerulosclesoris. (2011)
  • Author(s): Kanda S, Harita Y, Shibagaki Y, et al.
  • Journal Title: Molecular Biology of the Cell
  • Peer Reviewed
• [Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney. (2010)
  • Author(s): Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T
  • Journal Title: Nephrol Dial Transplant Volume: 25 Pages: 1785-95
• [Journal Article] Renal manifestations, progression and pathological findings in patients with R702 mutations in MYH9. (2010)
  • Author(s): SekineT, Konno M, Sasaki S, Moritani Sm Miura T, Wong WS, Nishio H Nishiguchi T, Yoshinari M, Tsuchiya S, Matsuyama T, Kanegane H, Ida K, Miura K, Harita Y, Igarashi T, Hattori M, Horita S, Saito H, Kunishima S
  • Journal Title: Kidney Int. Volume: 8 Pages: 207-14
• [Journal Article] ASPP2 regulates epithelial cell polarity through the PAR complex. (2010)
  • Author(s): Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, Ohno S
  • Journal Title: Curr Biol. Volume: 20 Pages: 1408-14
• [Journal Article] SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulus. (2010)
  • Author(s): Kurihara H, Harita Y, Ichimura K, Hattori S, Sakai T
  • Journal Title: Am J Physiol Renal Physiol Volume: 299
• [Journal Article] Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection. (2010)
  • Author(s): Morita T, Ashida A, Fujieda A, Hayashi A, Meda A, Ohta K, Shimizu M, Sekine T, Igarashi T, Tamai H, Wakiguchi H
  • Journal Title: Clin Nephrol Volume: 73 Pages: 398-402
• [Journal Article] Case report: Prenatal intervention for severe anterior urethral valve. (2010)
  • Author(s): Mizuno Y, Tsuchida S, Kakiuchi S, Ishiguro A, Goishi K, Kamei Y, Kanamori Y, Yamazaki Y, Sekine T, Igarashi T
  • Journal Title: Pediatr Inter Volume: 52
• [Journal Article] Patients with Epstein-Fechtner syndrome owing to MYH9 R702 mutations develop progressive proteinuric renal disease. (2010)
  • Author(s): Sekine T, Konno M, Sasaki S, Moritani S, Miura T, Wong WS, Nishio H, Nishiguchi T, Ohuchi MY, Tsuchiya S, Matsuyama T, Kanegane H, Ida K, Miura K, Harita Y, Hattori M, Horita S, Igarashi T, Saito H, Kunishima S
  • Journal Title: Kidney Int Volume: 78 Pages: 207-214
• [Journal Article] Skin and subcutaneous blood flows of very low birth weight infants during the first 3 postnatal days. (2010)
  • Author(s): Ishiguro A, Sekine T, Kakiuchi S, Nishimura R, Goishi K, Tsuchida S, Ohtsu H, Igarashi T
  • Journal Title: J Matern Fetal Neonatal Med Volume: 23 Pages: 522-528
• [Journal Article] Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection (2010)
  • Author(s): Morita T, Ashida A, Fujieda M, Hayash A, Maeda A, Ohta K, Shimizu M, Sekine T, Igarashi T, Tamai H, Wakiguchi H
  • Journal Title: Clinical Nephrol Volume: 73 Pages: 398-402
• [Journal Article] Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease. (2010)
  • Author(s): Sekine T, Konno M, Sasaki S, Moritani S, Miura T, Wong WS, Nishio H, Nishiguchi T, Ohuchi MY, Tsuchiya S, Matsuyama T, Kanegane H, Ida K, Miura K, Harita Y, Hattori M, Horita S, Igarashi T, Saito H, Kunishima S
  • Journal Title: Kidney Int Volume: 78 Pages: 207-214
• [Journal Article] Defective membrane expression of the Na+-HCO3- cotransporter NBCe1 is associated with familial migraine. (2010)
  • Author(s): Suzuki M, Paesschen WV, Stalmans I, Horita S, Yamada H, Bergmans BA, Legius E, Riant F, Jonghe PD, Li Y, Sekine T, Igarashi T, Fujimoto I, Mikoshiba K, Shimadzu M, Shohara M, Braverman N, Al-Gazali L, Fujita T, Seki J
  • Journal Title: Pnas Volume: 107 Pages: 15963-15968
• [Journal Article] Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling. (2010)
  • Author(s): Tasaki S, Nagasaki M, Kozuka-Hata H, Semba K, Gotoh N, Hattori S, Inoue J, Yamamoto T, Miyano S, Sugano S, Oyama M
  • Journal Title: PLoS One Volume: 5
• [Journal Article] SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulus. (2010)
  • Author(s): Kurihara H, Harita Y, Ichimura K, et al.
  • Journal Title: American Journal of Physiology. Renal Physiology Volume: 299 Pages: 517-527
  • Peer Reviewed
• [Journal Article] ASPP2 regulates epithelial cell polarity through the PAR complex. (2010)
  • Author(s): Cong W, Hirose T, Harita Y, et al.
  • Journal Title: Current Biology Volume: 20 Pages: 1408-1414
  • Peer Reviewed
• [Presentation] スリット膜複合体のターンオーバーを制御するメカニズム (2012)
  • Author(s): 張田豊
  • Organizer: 第7回弥彦ポドサイトセミナー
  • Place of Presentation: 新潟(招待講演)
  • Year and Date: 2012-03-03
• [Presentation] Toward the practical use of nephrin peptides as a TRPC6 inhibitor (2011)
  • Author(s): Kaada S, Harita Y, Igarashi T, et al
  • Organizer: American Society of Nephrology
  • Place of Presentation: 米国、Philadelphia
  • Year and Date: 2011-11-08
• [Presentation] 蛋白尿-ポドサイトロジーが迫るその本質- (2011)
  • Author(s): 張田豊
  • Organizer: 第17回Rokko Nephrology Research Forum
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2011-10-11
• [Presentation] 限外濾過膜としてのスリット膜のターンオーバーのメカニズム (2011)
  • Author(s): 佐藤大輔、張田豊, 他
  • Organizer: 第100回東京腎生理集談会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-10
• [Presentation] プロテオミクス:スリット膜リン酸化シグナルの解析 (2011)
  • Author(s): 張田豊
  • Organizer: 第33回腎臓セミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-08-11
• [Presentation] 蛋白尿の分子メカニズム (2011)
  • Author(s): 張田豊
  • Organizer: 第11回静岡小児腎臓病学術講演会
  • Place of Presentation: 焼津(招待講演)
  • Year and Date: 2011-07-16
• [Presentation] スリット膜のターンオーバー制御を担う分子機構の解明 (2011)
  • Author(s): 佐藤大輔、張田豊, 他
  • Organizer: 第54回日本腎臓学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-16
• [Presentation] Molecular mechanism regulating the turnover of nephiin (2011)
  • Author(s): Sato D, Harita Y, Igarashi T, et al
  • Organizer: The 11th Asian Congress of Pediatric Nephrology
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-02
• [Presentation] Development of TRPC6 inhibitor-antagonistic role of nephrin peptide on TRPC6 activation- (2011)
  • Author(s): Kanda S, Harita Y, Igarashi T, et al
  • Organizer: The 11th Asian Congress of Pediatric Nephrology
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-02
• [Presentation] ネフローゼ発症におけるTRPC6活性化メカニズム (2010)
  • Author(s): 神田祥一郎、張田豊、五十嵐隆, 他
  • Organizer: 第1回分子腎臓フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2010-09-04
• [Presentation] The role of the tyrosine phosphorylation of TRPC6 in proteinuric kidney diseases (2010)
  • Author(s): Kanda S, Harita Y, Sekine T, et al.
  • Organizer: The 15th congress of the International Pediatric Nephrology Association
  • Place of Presentation: New York, USA
  • Year and Date: 2010-09-01
• [Presentation] Podocyte Signal Transduction (2010)
  • Author(s): Harita Y
  • Organizer: Congress of International Pediatric Nephrology Association
  • Place of Presentation: New York, USA
  • Year and Date: 2010-08-31
• [Presentation] ネフローゼ症候群発症におけるTRPC6活性化メカニズム (2010)
  • Author(s): 神田祥一郎、張田豊、関根孝司, 他
  • Organizer: 第45回日本小児腎臓病学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-02
• [Presentation] 新規スリット膜構成分子SIRP-alphaはNephrinと結合し、そのリン酸化を負に制御する (2010)
  • Author(s): 張田豊、松長敦子、鶴見晴子, 他
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] ネフローゼ症候群発症におけるTRPC6活性化メカニズムの解析 (2010)
  • Author(s): 神田祥一郎、張田豊、関根孝司, 他
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-16
• [Presentation] The regulatory mechanism of TRPC6 activation by FSGS-causing mutations (2010)
  • Author(s): Kanda S, Harita Y, Sekine T, et al.
  • Organizer: Korea-Japan The 8th Pediatric Nephrology Seminar
  • Place of Presentation: 慶州,韓国
  • Year and Date: 2010-05-29
• [Presentation] Phosphorylation-mediated signaling in glomerular podocyte and its implication in the pathogenesis of proteinuria (2010)
  • Author(s): Harita Y, Kanda S, Sekine T, et al.
  • Organizer: Pediatric Academic Societies Annual Meeting
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-05-02
• [Presentation] Phosphorylation-dependent membrane insertion and activation of TRPC6 is regulated by a balance between Nephrin and PLC-γ1 (2010)
  • Author(s): Kanda S, Harita Y, Sekine T, et al.
  • Organizer: 6^<th> Asian Society for Pediatric Research
  • Place of Presentation: Taipei,台湾
  • Year and Date: 2010-04-17
• [Presentation] Epithelial Protein Lost in Neoplasm (EPLIN) Regulates Actin Dynamics and Motility of Glomerular Mesangial Cells.
  • Author(s): Tsurumi H, Harita Y, Miura K, and Igarashi T.
  • Organizer: Pediatric Academic Societies Annual Meeting,
  • Place of Presentation: Boston, USA
• [Presentation] Composition of slit diaphragm complex in congenital nephritic syndrome.
  • Author(s): Kajiho Y, Harita Y, Tsurumi H, Miura K, Hattori M, and Igarashi T
  • Organizer: 8th congress of Asian Society of Pediatric Research
  • Place of Presentation: Seoul, Korea
• [Presentation] Epithelial protein lost in neoplasm (EPLIN) regulates actin dynamics and motility of glomerular mesangial cells.
  • Author(s): Tsurumi H, Harita Y, Kajiho Y, Kanda S, Miura K, Sekine T, Hattori M, Igarashi T
  • Organizer: 8th congress of Asian Society of Pediatric Research
  • Place of Presentation: Seoul, Korea
• [Presentation] Epithelial protein lost in neoplasm (EPLIN) interacts with paxillin and regulates mesangial migration.
  • Author(s): Tsurumi H, Harita Y, Kajiho Y, Kanda S, Miura K, Sekine T, Hattori M, Igarashi T
  • Organizer: ASN Kidney Week
  • Place of Presentation: San Diego, USA
• [Presentation] 特別企画 FSGSの移植後再発のメカニズム
  • Author(s): 張田豊、石塚喜代伸
  • Organizer: 第47回 小児腎臓病学会
  • Place of Presentation: 東京
• [Presentation] 蛋白尿の発症機序(シンポジウム)
  • Author(s): 張田豊
  • Organizer: 第115回 小児科学会学術講演会
  • Place of Presentation: 福岡
• [Presentation] 先天性ネフローゼ症候群におけるスリット膜複合体形成
  • Author(s): 梶保祐子、張田豊、鶴見晴子、三浦健一郎、五十嵐隆
  • Organizer: 第55回 日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] EPLIN(Epithelial protein lost in neoplasm)はアクチン細胞骨格を介してメサンギウム細胞の運動性を制御する
  • Author(s): 鶴見晴子、張田豊、栗原秀剛、神田祥一郎、三浦健一郎、梶保祐子、関根孝司、服部成介、服部元史、五十嵐隆
  • Organizer: 第55回 日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] RacGAP因子FilGAPはAfadinと結合し、腎糸球体上皮細胞におけるアクチン細胞骨格形成を制御する。
  • Author(s): 椎野 達大, 斉藤 康二, 望月 優加, 栗原 秀剛, 張田 豊, 柴垣 芳夫, 服部 成介, 太田 安隆
  • Organizer: 35回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] メサンギウム細胞の運動性を制御するメカニズムーアクチン結合蛋白質EPLIN(Epithelial protein lost in neoplasm)の役割—
  • Author(s): 鶴見晴子、張田豊、栗原秀剛、神田祥一郎、三浦健一郎、梶保祐子、関根孝司、服部成介、服部元史、五十嵐隆
  • Organizer: 第47回 小児腎臓病学会
  • Place of Presentation: 東京
• [Book] 小児腎疾患の臨床(改訂第5版) (2012)
  • Author(s): 五十嵐隆
  • Total Pages: 310
  • Publisher: 診断と治療社
• [Book] 小児腎疾患の臨床改訂第4版 (2010)
  • Author(s): 五十嵐隆
  • Total Pages: 332
  • Publisher: 診断と治療社
• [Patent(Industrial Property Rights)] ポリペプチド (2010)
  • Inventor(s): 神田祥一郎、張田豊、服部成介、五十嵐隆、井上貴文
  • Industrial Property Rights Holder: 国立大学法人東京大学,学校法人北里研究所,学校法人早稲田大学
  • Acquisition Date: 2010-08-03
• [Patent(Industrial Property Rights)] ポリペプチド (2010)
  • Inventor(s): 神田祥一郎、張田豊, 服部成介, 五十嵐隆, 井上貴文
  • Industrial Property Rights Holder: 東京大学, 北里研究所, 早稲田大学
  • Industrial Property Number: 2010-174155
  • Filing Date: 2010-08-03