Elucidation of a molecular mechanism of osteoporosis caused by a mutation in the STAT3 gene
| Project/Area Number |
22390205
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima (2012)
Tokyo Medical and Dental University (2010-2011) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 免疫不全症 / 骨粗鬆症 / STAT3 / RANKリガンド / 原発性免疫不全症 / モデルマウス / 骨芽細胞 / 破骨細胞 / 高IgE症候群 / ノックインマウス |
|---|
| Research Abstract |
Hyper-IgE syndrome is a primary immunodeficiency characterized by recurrent staphylococcal infections and atopic dermatitisassociated with elevated serum IgE levels. We recently identified dominant negative (DN) mutations in the STAT3gene is the most common cause of hyper-IgE syndrome associated with bone abnormalities. Here we established Stat3-DN knock-in mice and foundbone formation and osteoclast generation induced by osteoblasts were impaired in the Stat3-DN mice.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] Deenick EK, Tangye SG. Functional STAT3 deficiency compromises the generation of human T follicular helper cells.2012
Author(s)
Ma CS, Avery DT, Chan A, Batten M, Bustamante J, Boisson-Dupuis S, Arkwright PD, Kreins AY, Averbuch D, Engelhard D, Magdorf K, Kilic SS, Minegishi Y, Nonoyama S, French MA, Choo S, Smart JM, Peake J, Wong M, Gray P, Cook MC, Fulcher DA
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Journal Title
Blood
Volume: 119
Issue: 17
Pages: 3997-4008
DOI
Related Report
Peer Reviewed
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[Journal Article] Functional STAT3 deficiency compromises the generation of human T follicular helper cells2012
Author(s)
Ma CS, Avery DT, Chan A, Batten M, Bustamante J, Boisson-Dupuis S, Arkwright PD, Kreins AY, Averbuch D, Engelhard D, Magdorf K, Kilic SS, Minegishi Y, Nonoyama S, French MA, Choo S, Smart JM, Peake J, Wong M, Gray P, Cook MC, Fulcher DA, Casanova JL, Deenick EK, Tangye SG
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Related Report
Peer Reviewed
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[Journal Article] Defective IL-10 signaling in hyper-IgE syndrome results in impaired gene ration of tolerogenic dendritic cells and induced regulatory T cells2011
Author(s)
Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Nonoyama S, Karasuyama H, Minegishi Y
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Journal Title
J Exp Med
Volume: 208
Pages: 235-249
Related Report
Peer Reviewed
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[Journal Article] Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.2011
Author(s)
Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Nonoyama S, Karasuy ama H, Minegishi Y.
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Journal Title
J Exp Med
Volume: 208
Pages: 235-249
Related Report
Peer Reviewed
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[Journal Article] Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.2010
Author(s)
Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, O hnuma N, Obata K, Ishikawa R, Yoshikawa S, Mukai K, Kawano Y, Minegishi Y, Yokozeki H, Watanabe N, Karasuya
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Journal Title
J Clin Invest.
Volume: 120
Pages: 2867-2875
Related Report
Peer Reviewed
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[Presentation] Hyper-IgE syndrome2012
Author(s)
Minegishi Y
Organizer
15th biennial meeting of European Society for Immunodeficiency
Place of Presentation
Firenze Fiera Congress&Exhibition Center, Italy
Related Report
Invited
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[Presentation] Hyper-IgE Syndrome and STAT3"2010
Author(s)
Minegishi Y, Saito M. Karasuyama H.
Organizer
European Society for Immunodeficiency
Place of Presentation
Instanbul Congress Center, Istanbul, Turkey
Year and Date
2010-10-10
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