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Molecular mechanisms underlying development and interaction of progenitor cells essential for cardiac outflow tract morphogenesis

Research Project

Project/Area Number 22390211
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKeio University

Principal Investigator

YAMAGISHI Hiroyuki  慶應義塾大学, 医学部, 講師 (40255500)

Co-Investigator(Kenkyū-buntansha) UCHIDA Keiko  慶應義塾大学, 医学部, 共同研究員 (50286522)
YAMAGISHI Chihiro  慶應義塾大学, 医学部, 共同研究員 (10296618)
TSUCHIHASHI Takatoshi  慶應義塾大学, 医学部, 共同研究員 (10286528)
KODO Kazuki  慶應義塾大学, 医学部, 助教 (10338105)
MAKINO Shinji  慶應義塾大学, 医学部, 特任准教授 (20306707)
YUASA Shinsuke  慶應義塾大学, 医学部, 講師 (90398628)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords小児循環器学 / 形態形成 / 細胞分化 / 発生医学 / 分子生物学 / モデル動物 / 先天性心疾患 / 形熊形成
Research Abstract

Two progenitor cell lineages, the cardiac neural crest cells (cNCCs) and the second heart field (SHF), play key roles in development of the cardiac outflow tract (OFT), and their interaction is essential for establishment of completely separated pulmonary

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (67 results)

All 2012 2011 2010 Other

All Journal Article (24 results) (of which Peer Reviewed: 17 results) Presentation (37 results) (of which Invited: 5 results) Book (6 results)

  • [Journal Article] Factors involved in signal transduction during vertebrate myogenesis2012

    • Author(s)
      Takagaki Y, Yamagishi H, Matsuoka R
    • Journal Title

      International Review of Molecular Biology

      Volume: 296 Pages: 187-272

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects2012

    • Author(s)
      Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, FukudaK, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
    • Journal Title

      Circ J

      Volume: 76(7) Pages: 1703-1711

    • NAID

      10030503588

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects.2012

    • Author(s)
      Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, Fukuda K, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 1703-1711

    • NAID

      10030503588

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors Involved in Signal Transduction During Vertebrate Myogenesis.2012

    • Author(s)
      Takagaki Y, Yamagishi H, Matsuoka R.
    • Journal Title

      International Review of Molecular Biology

      Volume: 296 Pages: 187-272

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 神経堤細胞と先天性心疾患2012

    • Author(s)
      山岸敬幸
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 28 Pages: 110-116

    • NAID

      10030960651

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 心臓流出路発生における新たな分子メカニズムの解明 二次心臓領域と心臓神経堤の分子発生学2012

    • Author(s)
      古道一樹、山岸敬幸
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 28 Pages: 206-210

    • NAID

      10031121943

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 先天性心疾患の周産期管理アップデート 心臓の発生2012

    • Author(s)
      柴田 映道、石崎 怜奈、山岸 敬幸
    • Journal Title

      周産期医学

      Volume: 42 Pages: 1221-1228

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Genetic Analysis of Essential Cardiac Transcription Factors in 256 Pati-ents with Non-Syndromic Congenital Heart Defects2012

    • Author(s)
      Kodo K, Yamagishi H, et al
    • Journal Title

      Circulation Journal

      Volume: (In press)

    • NAID

      10030503588

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of cardiac surgery in patients with trisomy 18 and trisomy 13 in Japan2011

    • Author(s)
      Maeda J, Yamagishi H, Furutani Y, Kamisago M, Waragai T, Oana S, Kajino H, Matsuura H, Mori K, Matsuoka R, Nakanishi T
    • Journal Title

      Am J Med Genet A

      Volume: 155A(11) Pages: 2641-2646

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field2011

    • Author(s)
      Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H
    • Journal Title

      J Mol Cell Cardiol

      Volume: 51 Pages: 58-66

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hand2 function in second heart field progenitors is essential for cardiogenesis2011

    • Author(s)
      Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D
    • Journal Title

      Dev Biol

      Volume: 351 Pages: 62-69

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The antiproliferative action of progesterone in uterine epithelium is mediated by Hand22011

    • Author(s)
      Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC
    • Journal Title

      Science

      Volume: 331 Pages: 912-916

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Impact of Cardiac Surgery in Patients with Trisomy 18 and Trisomy 13 in Japan2011

    • Author(s)
      Maeda J, Yamagishi H, et al
    • Journal Title

      American Journal of Medical Genetics

      Volume: 155A Pages: 2641-2646

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A decade of advances in molecular embryology and genetics underlying congenital heart defects2011

    • Author(s)
      Kodo K, Yamagishi H
    • Journal Title

      Circulation Journal

      Volume: 75 Pages: 2296-2304

    • NAID

      10029458960

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field2011

    • Author(s)
      Nakazawa M, Yamagishi H, et al
    • Journal Title

      Journal of Molecular Cellular Cardiology

      Volume: 51 Pages: 58-66

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 先天性心疾患の遺伝子研究2011

    • Author(s)
      山岸敬幸
    • Journal Title

      進歩する心臓研究-Tokyo Heart Journal-

      Volume: 58 Pages: 31-39

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 心臓の発生・発達とカルシウムシグナル2011

    • Author(s)
      内田敬子、山岸敬幸
    • Journal Title

      心臓

      Volume: 43 Pages: 615-619

    • NAID

      130002146605

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 先天性心疾患とRSウイルス感染症2011

    • Author(s)
      柴田映道、山岸敬幸
    • Journal Title

      小児科

      Volume: 52 Pages: 1477-1486

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Hand2 function in second heart field progenitors is essential for cardiogenesis2011

    • Author(s)
      Tsuchihashi T, Yamagishi H, et al.
    • Journal Title

      Developmental Biology

      Volume: 351 Pages: 62-69

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field2011

    • Author(s)
      Nakazawa M, Yamagishi H, et al.
    • Journal Title

      Journal of Molecular Cellular Cardiology

      Volume: (Epub)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis2010

    • Author(s)
      Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H
    • Journal Title

      PLoS One

      Volume: 5(9)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin2010

    • Author(s)
      Fukushima H, Kosaki K, Sato R, Yagihashi T, Gatayama R, Kodo K, Hayashi T, Nakazawa M, Tsuchihashi T, Maeda J, Kojima Y, Yamagishi H, Takahashi T
    • Journal Title

      Am J Med Genet A

      Volume: 152A Pages: 1919-1924

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis2010

    • Author(s)
      Uchida K, Yamagishi H, et al.
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GATA transcription factors in congenital heart defects2010

    • Author(s)
      Kodo K, Yamagishi H
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Pages: 637-638

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小児循環器医のための発生学と臨床遺伝2012

    • Author(s)
      山岸敬幸
    • Organizer
      第7回愛媛発達心臓病研究会
    • Place of Presentation
      松山
    • Year and Date
      2012-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 先天性心疾患の心エコー図に役立てたい臨床心臓発生学2012

    • Author(s)
      山岸敬幸
    • Organizer
      第52回東京心エコー図研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-24
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 胎児心スクリーニングに役立つ発生学の知識2012

    • Author(s)
      山岸敬幸
    • Organizer
      第50回神奈川胎児エコー研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-13
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 先天性心疾患を科学する 臨床心臓発生学のスゝメ2012

    • Author(s)
      山岸敬幸
    • Organizer
      日本小児科学会栃木県地方会
    • Place of Presentation
      宇都宮
    • Year and Date
      2012-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 基礎・心臓の発生 房室中隔の発生2012

    • Author(s)
      山岸敬幸
    • Organizer
      第48回日本小児循環器学会学術集会・教育セッション
    • Place of Presentation
      京都
    • Year and Date
      2012-07-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 先天性心疾患の発症分子機構解明と臨床心臓発生学の発展2012

    • Author(s)
      山岸敬幸
    • Organizer
      第48回日本小児循環器学会『高尾賞』受賞記念講演
    • Place of Presentation
      京都
    • Year and Date
      2012-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 成人先天性心疾患の基礎知識・先天性心疾患と遺伝2012

    • Author(s)
      山岸敬幸
    • Organizer
      第6回成人先天性心疾患セミナー
    • Place of Presentation
      東京
    • Year and Date
      2012-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 臨床心臓発生学の進歩2012

    • Author(s)
      山岸敬幸
    • Organizer
      第21回京都小児循環器病カンファレンス
    • Place of Presentation
      京都
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 心臓におけるIP3レセプターの新たな機能2012

    • Author(s)
      山岸敬幸
    • Organizer
      日本生理学会
    • Place of Presentation
      松本文化会館(長野県)(招待講演)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Embryology and morphology of heterotaxy connecting to clinical activity2012

    • Author(s)
      Yamagishi H
    • Organizer
      Mt.Fuji Network Forum
    • Place of Presentation
      Granship (Shizuoka, Japan)(招待講演)
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 世界に発信する小児循環器の基礎研究 -臨床心臓発生学のすゝめ-2012

    • Author(s)
      山岸敬幸
    • Organizer
      The 6th CSR Research Seminar
    • Place of Presentation
      奈良
    • Year and Date
      2012-02-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of Upstream Regulatory Mechanisms of Semaphorin 3c Signaling During the Development of the Outflow Tract2011

    • Author(s)
      Kodo K, Yamagishi H, et al
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 先天性心疾患診療のための発生学・遺伝学の基本と新たな流れ2011

    • Author(s)
      山岸敬幸
    • Organizer
      第5回鹿児島小児循環器研究会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2011-08-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 世界をリードする臨床心臓発生学研究2011

    • Author(s)
      山岸敬幸
    • Organizer
      第94回慈恵医大小児医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 基礎発生・神経堤細胞と先天性心疾患2011

    • Author(s)
      山岸敬幸
    • Organizer
      第47回日本小児循環器学会・教育セッション
    • Place of Presentation
      福岡
    • Year and Date
      2011-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経堤細胞と先天性心疾患2011

    • Author(s)
      山岸敬幸
    • Organizer
      日本小児循環器学会
    • Place of Presentation
      福岡国際会議場(福岡県)(招待講演)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 先天性心疾患の遺伝子研究2011

    • Author(s)
      山岸敬幸
    • Organizer
      第73回東京心臓の会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 成人先天性心疾患の診療に必要な遺伝の知識2011

    • Author(s)
      山岸敬幸
    • Organizer
      第4回成人先天性心疾患セミナー
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel transcriptional cascade controlling the Semaphorin-Plexin signaling during heart development2011

    • Author(s)
      Kodo K, Yamagishi H, et al
    • Organizer
      Weinstein Cardiovascular Conference
    • Place of Presentation
      Cincinnati, USA
    • Year and Date
      2011-05-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Developmental origins of syndromic and non-syndromic cardiac outflow tract defects2011

    • Author(s)
      Yamagishi H
    • Organizer
      Pediatric Academic Society (PAS/ASPR) 2011・Topic symposium: Molecular Pathogenesis of Cardiovascular Diseases of Childhood
    • Place of Presentation
      Denver, USA
    • Year and Date
      2011-05-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Developmental origins of syndromic and non-syndromic cardiac defects2011

    • Author(s)
      Yamagishi H
    • Organizer
      Pediatric Academic Society (PAS/ASPR) 2011
    • Place of Presentation
      Denver, USA(招待講演)
    • Year and Date
      2011-05-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 先天性心疾患成因にアプローチするための臨床心臓発生学2011

    • Author(s)
      山岸敬幸
    • Organizer
      第49回山梨小児循環器懇話会
    • Place of Presentation
      山梨
    • Year and Date
      2011-03-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Comprehensive genetic approach for congenital heart diseases revealed sequence variants in cardiac progenitor marker genes2010

    • Author(s)
      Kodo K, Yamagishi H, et al.
    • Organizer
      American Heart Association Scientific Session2010
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先天性心疾患の成因と遺伝カウンセリング2010

    • Author(s)
      山岸敬幸
    • Organizer
      第187回大阪小児科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-26
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 心室中隔欠損の臨床と発生2010

    • Author(s)
      山岸敬幸
    • Organizer
      第9回心臓血管発生研究会・教育セッション
    • Place of Presentation
      郡山
    • Year and Date
      2010-07-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 心室中隔欠損の臨床と発生2010

    • Author(s)
      山岸敬幸
    • Organizer
      第9回心臓血管発生研究会
    • Place of Presentation
      浦安千葉
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cardiovascular morphogenesis and development of the systemic and pulmonary circulation.2010

    • Author(s)
      Yamagishi H
    • Organizer
      The 7th Scientific Symposium
    • Place of Presentation
      東京
    • Year and Date
      2010-07-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Comprehensive candidate approach for identification of sequence variant in cardiac transcription factors in patients with congenital heart defects2010

    • Author(s)
      Kodo K, Yamagishi H, et al.
    • Organizer
      Weinstein 2010 Cardiovascular Development Conference
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] こどもの心臓病のために学ぶ、発生と遺伝の初歩2010

    • Author(s)
      山岸敬幸
    • Organizer
      第113回日本小児科学会学術集会・教育セミナー
    • Place of Presentation
      岩手
    • Year and Date
      2010-04-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 先天性心疾患の分子遺伝学的解明2010

    • Author(s)
      山岸敬幸
    • Organizer
      第113回日本小児科学会学術集・分野別シンポジウム
    • Place of Presentation
      岩手
    • Year and Date
      2010-04-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 先天性心疾患の分子遺伝学的解明2010

    • Author(s)
      山岸敬幸
    • Organizer
      第113回日本小児科学会学術集会
    • Place of Presentation
      盛岡岩手
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] こどもの心臓病のために学ぶ、発生と遺伝の初歩2010

    • Author(s)
      山岸敬幸
    • Organizer
      第113回日本小児科学会学術集会(教育セミナー)
    • Place of Presentation
      盛岡岩手
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成人先天性心疾患の基礎知識 先天性心疾患と遺伝

    • Author(s)
      山岸敬幸
    • Organizer
      第6回成人先天性心疾患セミナー
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 先天性心疾患の発症分子機構解明と臨床心臓発生学の発展

    • Author(s)
      山岸敬幸
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 基礎・心臓の発生 房室中隔の発生

    • Author(s)
      山岸敬幸
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 先天性心疾患を科学する 臨床心臓発生学のスゝメ

    • Author(s)
      山岸敬幸
    • Organizer
      日本小児科学会栃木県地方会
    • Place of Presentation
      栃木
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 小児循環器医のための発生学と臨床遺伝

    • Author(s)
      山岸敬幸
    • Organizer
      第7回愛媛発達心臓病研究会
    • Place of Presentation
      愛媛
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 新・心臓病診療プラクティス18大人になった先天性心疾患2012

    • Author(s)
      山岸敬幸、柴田映道
    • Total Pages
      275
    • Publisher
      文光堂
    • Related Report
      2011 Annual Research Report
  • [Book] 小児科診療ガイドライン(第2版)2011

    • Author(s)
      潟山亮平、山岸敬幸
    • Total Pages
      558
    • Publisher
      総合医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 小児科臨床ピクシス26小児慢性疾患のサポート2011

    • Author(s)
      山岸敬幸、仲澤麻紀
    • Total Pages
      275
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] EBM小児疾患の治療(五十嵐隆監修、石井正浩, ほか編)2011

    • Author(s)
      土橋隆俊、山岸敬幸
    • Total Pages
      707
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] 循環器疾患のサイエンス(小室一成編)2010

    • Author(s)
      山岸敬幸、古道一樹
    • Total Pages
      236
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report
  • [Book] 先天性心疾患のMDCT(陣崎雅弘編)2010

    • Author(s)
      山岸敬幸、仲澤麻紀
    • Total Pages
      152
    • Publisher
      文光堂
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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