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Elucidation of mesenchymal to epithelial transition mechanism of bone marrow mesenchymal stem cells and application to regenerative medicine.

Research Project

Project/Area Number 22390217
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionOsaka University

Principal Investigator

TAMAI Katsuto  大阪大学, 医学系研究科, 寄附講座教授 (20236730)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywords骨髄間葉系幹細胞 / 間葉上皮転換(MET) / HMGB1 / CXCL12 / CXCR4 / 間葉系幹細胞 / 表皮水疱症 / VII型コラーゲン / SDF-1α / 間葉-上皮転換 / SSEA3 / ケラチン5 / 再生誘導 / 皮膚損傷
Research Abstract

Previously, we had shown that bone marrow-derived mesenchymal stem/progenitor cells contribute regeneration of detached epithelia in the skin of epidermolysis bullosa (EB), a intractable genetic skin disease. With such background, in this study, we aimed to investigate precise mechanism of mesenchymal to epithelial transition (MET) of bone marrow-derived mesenchymal cells in the EB skin, and to apply the obtained results for developing novel regenerative medicine. In 2012, we found that injured epithelia of EB skin release abundant high mobility group box 1 (HMGB1) to stimulate and mobilize lineage-/PDGFR.+/c-kit- (L-P+K-) bone marrow cells into the circulation, and the circulating L-P+K- cells are then accumulate to the injured skin via CXCR4/SDF-1. axis to provide bone marrow-derived epithelial cells by MET. In 2013, we further investigated particular cell surface marker for identifying MET-capable cell in L-P+K- population, and clarified that SSEA3 is an exclusive maker for specifically identifying the MET-capable cells in the L-P+K- cell population. We also proved that L-P+K- bone marrow-derived cells are essential for regeneration of EB skin by blocking accumulation of those cells by systemic inoculating CXCR4 antagonist in EB mouse model, resulting in persistent severe cutaneous injury. In 2014, we examined efficacy of systemic administration of HMGB1 on regeneration processes of cutaneous injury, and found that HMGB1 administration significantly accelerate tissue regeneration by inducing accumulation of L-P+K- cells in the injury, which then provide potent anti-inflammatory molecules and regenerate the injured epithelia by MET.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (71 results)

All 2013 2012 2011 2010 Other

All Journal Article (27 results) (of which Peer Reviewed: 13 results) Presentation (39 results) (of which Invited: 4 results) Book (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 4 results)

  • [Journal Article] Systemic Circulation and Bone Recruitment of Osteoclast Precursors Tracked by Using Fluorescent Imaging Techniques.2013

    • Author(s)
      Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M
    • Journal Title

      J Immunol

      Volume: 190(2) Pages: 605-612

    • Related Report
      2012 Final Research Report
  • [Journal Article] Systemic administration of a novel immune-stimulatory pseudovirion suppresses lung metastatic melanoma by regionally enhancing IFN-γ production.2013

    • Author(s)
      Saga K, Tamai K, Yamazaki T, Kaneda Y
    • Journal Title

      Clin Cancer Res

      Volume: 19(3) Pages: 668-679

    • Related Report
      2012 Final Research Report
  • [Journal Article] The combination of chemistry with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma2012

    • Author(s)
      Kiyohara E.
    • Journal Title

      Gene Therapy

      Volume: 19 Issue: 7 Pages: 731-741

    • DOI

      10.1038/gt.2011.123

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early intra-amniotic gene transfer using lentiviral vector improves skin blistering phenotype in a murine model of Herlitz junctional epidermolysis bullosa.2012

    • Author(s)
      Endo M, Zoltick PW, Radu A, Qiujie J, Matsui C, Marinkovich PM, McGrath J, Tamai K, Uitto J, Flake AW
    • Journal Title

      Gene Ther

      Volume: 19(5) Issue: 5 Pages: 561-9

    • DOI

      10.1038/gt.2011.135

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function.2012

    • Author(s)
      Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
    • Journal Title

      FASEB J

      Volume: 26(6) Pages: 2306-2317

    • Related Report
      2012 Final Research Report
  • [Journal Article] Two cases of recessive dystrophic epidermolysis bullosa diagnosed as severe generalized.2012

    • Author(s)
      Ohashi M, Shu E, Nagai M, Murase K, Nakano H, Tamai K, Sawamura D, Hiroka T, Seishima M, Kitajima Y, Aoyama Y
    • Journal Title

      J Dermatol

      Volume: 38 Pages: 893-9

    • NAID

      10030728065

    • Related Report
      2012 Final Research Report
  • [Journal Article] The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa.2012

    • Author(s)
      Hanafusa T, Tamai K, Umegaki N, Yamaguchi Y, Fukuda S, Nishikawa Y, Yaegashi N, Okuyama R, McGrath JA, Katayama I
    • Journal Title

      Clin Exp Dermatol

      Volume: 37 Pages: 10-4

    • Related Report
      2012 Final Research Report
  • [Journal Article] Systemic administration of a novel immune-stimulatory pseudovirion suppresses lung metastatic melanoma by regionally enhancing IFN-γ production.2012

    • Author(s)
      Saga K, Tamai K, Yamazaki T, Kaneda Y.
    • Journal Title

      Clin Cancer Res

      Volume: Epub ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic Circulation and Bone Recruitment of Osteoclast Precursors Tracked by Using Fluorescent Imaging Techniques.2012

    • Author(s)
      Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M
    • Journal Title

      J Immunol.

      Volume: Epub ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of recessive dystrophic epidermolysis bullosa diagnosed as severe generalized.2012

    • Author(s)
      Ohashi M, Shu E, Nagai M, Murase K, Nakano H, Tamai K, Sawamura D, Hiroka T, Seishima M, Kitajima Y, Aoyama Y.
    • Journal Title

      J Dermatol

      Volume: 38 Pages: 893-899

    • NAID

      10030728065

    • Related Report
      2012 Annual Research Report
  • [Journal Article] The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa.2012

    • Author(s)
      Hanafusa T, Tamai K, Umegaki N, Yamaguchi Y, Fukuda S, Nishikawa Y, Yaegashi N, Okuyama R, McGrath JA, Katayama I.
    • Journal Title

      Clin Exp Dermatol.

      Volume: 37 Pages: 10-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa2012

    • Author(s)
      Hanafusa T, Tamai K, Umegaki N, Yamaguchi Y, Fukuda S, Nishikawa Y, Yaegashi N, Okuyama R, McGrath JA, Katayama I
    • Journal Title

      Clin Exp Dermatol

      Volume: 37 Issue: 1 Pages: 10-14

    • DOI

      10.1111/j.1365-2230.2011.04179.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exon 87 skipping of the COL7A1 gene in dominant dystrophic epidermolysis bullosa.2011

    • Author(s)
      Koga H, Hamada T, Ishii N, Fukuda S, Sakaguchi S, Nakano H, Tamai K, Sawamura D, Hashimoto T
    • Journal Title

      J Dermatol

      Volume: 38 Pages: 489-492

    • Related Report
      2012 Final Research Report
  • [Journal Article] Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus2011

    • Author(s)
      Fujita H, Tamai K, Kawachi M, Saga K, Shimbo T, Yamazaki T, Kaneda Y
    • Journal Title

      Arch Virol

      Volume: 156 Pages: 995-1005

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Vorner type palmoplantar keratoderma: novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation.2011

    • Author(s)
      Umegaki N, Nakano H, Tamai K, Mitsuhashi Y, Akasaka E, Sawamura D, Katayama I
    • Journal Title

      Br J Dermatol

      Volume: 165 Pages: 199-201

    • Related Report
      2012 Final Research Report
  • [Journal Article] PDGFR.-positive cells in bone marrow are mobilized by HMGB1 to regenerate injured epithelia.2011

    • Author(s)
      Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath JA, Uitto J, Kaneda Y
    • Journal Title

      Proc Natl Acd Sci USA

      Volume: 108 Pages: 6609-6614

    • Related Report
      2012 Final Research Report
  • [Journal Article] Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents.2011

    • Author(s)
      Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R, Tamai K, Tomono K, Kaneda Y
    • Journal Title

      J Cell Mol Med

      Volume: - Issue: 7 Pages: 1629-1639

    • DOI

      10.1111/j.1582-4934.2011.01406.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDGFRα-positive cells in bone marrow are mobilized by HMGB1 to regenerate injured epithelia2011

    • Author(s)
      Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath JA, Uitto J, Kanda Y
    • Journal Title

      Proc Natl Acd Sci USA

      Volume: 108 Pages: 6609-6614

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exon 87 skipping of the COL7A1 gene in dominant dystrophic epidermolysis bullosa2011

    • Author(s)
      Koga H, Hamada T, Ishii N, Fukuda S, Sakaguchi S, Nakano H, Tamai K, Sawamura D, Hashimoto T.Exon 87 skipping of the COL7A1 gene in domin ant dystrophic epidermolysis bullosa
    • Journal Title

      J Dermatol

      Volume: 38 Pages: 489-492

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vorner type palmoplantar keratoderma : novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation2011

    • Author(s)
      Umegaki N, Nakano H, Tamai K, Mitsuhashi Y, Akasaka E, Sawamura D, Katayama I
    • Journal Title

      Br J Dermatol

      Volume: 165 Pages: 199-201

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of recessive dystrophic epidermolysis bullosa diagnosed as severe generalized2011

    • Author(s)
      Ohashi M, Shu E, Nagai M, Murase K, Nakano H, Tamai K, Sawamura D, Hiroka T, Seishima M, Kitajima Y, Aoyama Y
    • Journal Title

      J Dermatol

      Volume: 38 Pages: 893-839

    • NAID

      10030728065

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus.2011

    • Author(s)
      Fujita H, Tamai K, Kawachi M, Saga K, Shimbo T, Yamazaki T, Kaneda Y.
    • Journal Title

      Arch Virol.

      Volume: (Epub)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic progenitor cells for de novo generation of bone tissue.2010

    • Author(s)
      Kimura Y, Miyazaki N, Hayashi N, Otsuru S, Tamai K, Kaneda Y, Tabata Y
    • Journal Title

      Tissue Eng Part A

      Volume: 16 Pages: 1263-1270

    • Related Report
      2012 Final Research Report
  • [Journal Article] Serum anti-BPAG1 auto-antibody is a novel marker for human melanoma.2010

    • Author(s)
      Shimbo T, Tanemura A, Yamazaki T, Tamai K, Katayama I, Kaneda Y
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Relation between the expression of level of the POU transcription factor Skn-1a and Skn-1n and keratinocyte differentiation.2010

    • Author(s)
      Takemoto H, Tamai K, Akasaka E, Rokunohe D, Takiyoshi N, Umegaki N, Nakajima K, Aizu T, Kaneko T, Nakano H, Sawamura D
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 203-205

    • NAID

      10027841207

    • Related Report
      2012 Final Research Report
  • [Journal Article] Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic progenitor cells for de novo generation of bone tissue.2010

    • Author(s)
      Kimura Y, Miyazaki N, Hayashi N, Otsuru S, Tamai K, Kaneda Y, Tabata Y.
    • Journal Title

      Tissue Eng Part A.

      Volume: 16 Pages: 1263-1270

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation between expression levels of the POU transcriptional factor Skn-1a and Skn-1n and keratinocyte differentiation.2010

    • Author(s)
      Takemoto H, Tamai K, Akasaka E, Rokunohe D, Takiyoshi N, Umegaki N, Nakajima K, Aizu T, Kaneko T, Nakano H, Sawamura D.
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 203-205

    • NAID

      10027841207

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 他家骨髄間葉系幹細胞移植による表皮水疱症治療研究:基礎と臨床2013

    • Author(s)
      玉井克人
    • Organizer
      第12回日本再生医療学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 幹細胞研究の展望:末梢循環性間葉系幹細胞の皮膚集積による病態変化.2012

    • Author(s)
      玉井克人
    • Organizer
      日本皮膚科学会中部支部学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 水疱症に対する骨髄間葉系幹細胞移植治療の可能性2012

    • Author(s)
      玉井克人、飯沼晋、菊池康、飯塚一、金田安史、片山一朗
    • Organizer
      第34回水疱症研究会
    • Place of Presentation
      弘前
    • Year and Date
      2012-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Injured tissue releases HMGB1 to recruit bone marrow mesenchymal stem cells for inducing regeneration of the injury2012

    • Author(s)
      Katsuto Tamai, Yasushi Kikuchi, Shin Iinuma, Yasufumi Kaneda
    • Organizer
      The 71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo,Japan
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] アトピー性皮膚炎に対するNFkBデコイDNA軟膏の展望2012

    • Author(s)
      玉井克人
    • Organizer
      第42回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      軽井沢
    • Year and Date
      2012-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 教育講演49 遙かにひろがる皮膚イメージング宇宙の旅:皮膚イメージング宇宙を旅する宇宙船皮膚号にようこそ2012

    • Author(s)
      玉井克人
    • Organizer
      第111回日本皮膚科学会総会・学術大会
    • Place of Presentation
      京都
    • Year and Date
      2012-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 教育講演6 研究を目指す若手皮膚科医のために 臨床医にとって研究とは? 臨床と研究は皮膚科学一卵性双生児である.2012

    • Author(s)
      玉井克人
    • Organizer
      第111回日本皮膚科学会総会・学術大会
    • Place of Presentation
      京都
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄間葉系幹細胞による皮膚再生機序を利用した表皮水疱症治療2012

    • Author(s)
      玉井克人
    • Organizer
      第2回国際遺伝病遺伝子治療フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2012-01-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Crosstalk mechanism between injured epithelia and bone marrow2012

    • Author(s)
      Katsuto Tamai
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      SanDiego
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mesenchymal stem cell transplantation for epidermolysis bullosa2012

    • Author(s)
      Katsuto Tamai
    • Organizer
      75th annnual meeting of Society of Investigative Dermatology
    • Place of Presentation
      Raleigh, North Carolina
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Injured tissue releases HMGB12012

    • Author(s)
      Katsuto Tamai
    • Organizer
      The 71st Annual Meeting of the Japanese Cancer Association,
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] 末梢循環性間葉系幹細胞の皮膚集積による病態変化2012

    • Author(s)
      玉井克人
    • Organizer
      第63回日本皮膚科学会中部支部学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] High mobility group box 1 (HMGB1) mobilizes mesenchymal stem cells from bone marrow to regenerate injured epithelia2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2011-12-09
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 骨髄と皮膚のクロストークを利用した皮膚病治療2011

    • Author(s)
      玉井克人
    • Organizer
      第63回日本皮膚科学会西部支部学術集会
    • Place of Presentation
      沖縄県那覇市
    • Year and Date
      2011-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄と皮膚のクロストークを利用した皮膚病治療2011

    • Author(s)
      玉井克人
    • Organizer
      第63回日本皮膚科学会西部支部学術集会
    • Place of Presentation
      沖縄県那覇市(招待講演)
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 表皮水疱症の剥離表皮再生メカニズムを利用した新しい治療戦略2011

    • Author(s)
      玉井克人
    • Organizer
      第35回日本小児皮膚科学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 表皮水疱症の剥離表皮再生メカニズムを利用した新しい治療戦略2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      第35回日本小児皮膚科学会
    • Place of Presentation
      横浜市(招待講演)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] HMGB1 mobilized PDGFRa-positive cells from bone marrow to regenerate injured epithelia2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      Japan Society of Gene Therapy 2011 17th Annual Meeting
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2011-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] HMGB1 mobilized PDGFRa-positive cells from bone marrow to regenerate injured epithelia2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      Japan Society of Gene Therapy 2011 17^<th> Annual Meeting
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 皮膚と骨髄のクロストーク2011

    • Author(s)
      玉井克人
    • Organizer
      日本皮膚科学会第357回福岡地方会
    • Place of Presentation
      福岡県久留米市
    • Year and Date
      2011-06-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮膚と骨髄のクロストーク2011

    • Author(s)
      玉井克人
    • Organizer
      日本皮膚科学会第357回福岡地方会
    • Place of Presentation
      福岡県久留米市(招待講演)
    • Year and Date
      2011-06-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 損傷組織と骨髄細胞のクロストークを利用した体内再生誘導医療開発2011

    • Author(s)
      玉井克人、飯沼晋、菊池康、金田安史
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Plenary lecture: Skin regeneration and repair by bone marrow-derived stem/progenitor cells.2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Successful treatment of severe facial atopic dermatitis with topical NF-kappa B decoy ointment2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Problems and future perspectives for gene therapy of genetic skin diseases2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Plenary lecture : Skin regeneration and repair by bone marrow-derived stem/progenitor cells2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      22^<nd> World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Successful treatment of severe facial atopic dermatitis with topical NF-kappa B decoy ointment2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      22^<nd> World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Problems and future perspectives for gene therapy of genetic skin diseases2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      22^<nd> World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cross-talk between skin and bone marrow2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      British Society of Investigative Dermatology Annual meeting
    • Place of Presentation
      Manchester, UK
    • Year and Date
      2011-04-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Cross-talk between skin and bone marrow2011

    • Author(s)
      Katsuto Tamai
    • Organizer
      British Society of Investigative Dermatology Annual meeting
    • Place of Presentation
      Manchester, UK(招待講演)
    • Year and Date
      2011-04-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨髄由来細胞による表皮水疱症皮膚再生医療2011

    • Author(s)
      玉井克人
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      東
    • Year and Date
      2011-03-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄由来細胞による表皮水疱症皮膚再生医療2011

    • Author(s)
      玉井克人
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨髄由来幹細胞による表皮再生2011

    • Author(s)
      玉井克人
    • Organizer
      第74回日本皮膚科学会東京支部学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄由来幹細胞による表皮再生2011

    • Author(s)
      玉井克人
    • Organizer
      第74回日本皮膚科学会東京支部学術大会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 表皮水疱症の病態2010

    • Author(s)
      玉井克人
    • Organizer
      第42回日本臨床分子形態学会
    • Place of Presentation
      三島
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 表皮水疱症の病態2010

    • Author(s)
      玉井克人
    • Organizer
      第42回日本臨床分子形態学会
    • Place of Presentation
      三島(招待講演)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 移植皮膚片における表皮恒常性維持機構2010

    • Author(s)
      玉井克人、知野剛直、飯沼晋、金田安史、梅垣知子、片山一朗
    • Organizer
      第25回角化症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-31
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Contribution of PDGFRα-positive bone marrow cells for epithelial regeneration in genetic blistering skin disease, RDEB.2010

    • Author(s)
      Katsuto Tamai, Takehiko Yamazaki, Takenao Chino, Yasuhumi Kaneda.
    • Organizer
      13th Annual Meeting, American Society of Gene and Cell Therapy
    • Place of Presentation
      Washington, DC, USA.
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Contribution of PDGFRα-positive bone marrow cells for epithelial regeneration in genetic blistering skin disease, RDEB.

    • Author(s)
      Katsuto Tamai, Takehiko Yamazaki, Takenao Chino and Yasuhumi Kaneda
    • Organizer
      3th Annual Meeting, American Society of Gene and Cell Therapy
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2012 Final Research Report
  • [Book] The Color Atlas of Disorders of Keratinization2011

    • Author(s)
      Katsuto Tamai
    • Publisher
      Kyowa Kikaku, LTD
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 組織再生を誘導するためのペプチドとその利用2012

    • Inventor(s)
      玉井克人 他
    • Industrial Property Rights Holder
      大阪大学、株式会社ジェノミックス
    • Filing Date
      2012-04-03
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 組織再生を誘導するためのペプチドとその利用2012

    • Inventor(s)
      玉井克人
    • Industrial Property Rights Holder
      玉井克人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-04-03
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 骨髄間葉系および/または多能性幹細胞の血中動員による組織再生促進剤2010

    • Inventor(s)
      玉井克人 他
    • Industrial Property Rights Holder
      大阪大学、株式会社ジェノミックス
    • Filing Date
      2010-10-28
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 骨髄間葉系および/または多能性幹細胞の血中動員による組織再生促進剤2010

    • Inventor(s)
      玉井克人、金田安史、知野剛直
    • Industrial Property Rights Holder
      大阪大学、株式会社ジェノミックス
    • Filing Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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