Molecular imaging of cholinergic system in the brain of autism: A positron emission tomography study.
| Project/Area Number |
22390221
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEI Noriyoshi 浜松医科大学, 子どものこころの発達研究センター, 教授 (80206937)
TSUCHIYA Kenji 浜松医科大学, 子どものこころの発達研究センター, 准教授 (20362189)
MIYACHI Taishi 浜松医科大学, 子どものこころの発達研究センター, 助教 (60444345)
NAKAMURA Kazuhiko 弘前大学, 医学系研究科, 教授 (80263911)
IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025)
TAKEBAYASHI Kiyokazu 浜松医科大学, 医学部附属病院, 講師 (50397428)
YOSHIHARA Yujiro 浜松医科大学, 医学部附属病院, 助教 (00529464)
SUDA Shiro 浜松医科大学, 子どものこころの発達研究センター, 助教 (40432207)
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| Co-Investigator(Renkei-kenkyūsha) |
OUCHI Yasuomi 浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978)
TUJII Masatugu 中京大学, 現代社会学部, 教授 (20257546)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 児童・思春期精神医学 / 分子イメージング / コリンエステラーゼ / PET / 自閉症 / 陽電子断層法 / アセチルコリンエステラーゼ / 広汎性発達障害 / 紡錘状回 |
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| Research Abstract |
Aim of this studywas todetermine whether central acetylcholinesterase activity, a marker for the cholinergic system, is altered in subjects with autism spectrum disorder (ASD).Using positron emission tomography and a radiotracer , [11C]MP4A regional cerebrocortical acetylcholinesterase (AChE) activities wereestimated by reference tissue-based linear least-squaresanalysisin 20 adult subjects with ASD (14 male and 6 female; age range, 18-33 years) and 20 age-, sex-, and IQ-matched healthy controls. Both voxel-and region of interest-based analyses revealed significantly lower AChE activities in the bilateral fusiform gyri of subjects with ASD than in thoseof controls (P
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011
Author(s)
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
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Journal Title
Arch Gen Psychiatry
Volume: 68
Pages: 306-313
Related Report
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[Journal Article] Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders2011
Author(s)
Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shinmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K, Tsuchiya KJ, Iwata Y, Nakamura K, Tsujii M, Sugiyama S, Mori N
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Journal Title
PLoS One
Volume: 6(5)
Issue: 5
Pages: e20470-e20470
DOI
Related Report
Peer Reviewed
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[Journal Article] Alteration of Plasma Glutamate and Glutamine Levels in Children with High-Functioning Autism2011
Author(s)
Shimmura C, Suda S, Tsuchiya KJ, Hashimoto K, Ohno K, Matsuzaki H, Iwata K, Matsumoto K, Wakuda T, Kameno Y, Suzuki K, Tsujii M, Nakamura K, Takei N, Mori N
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Journal Title
PLoS One
Volume: 6(10)
Issue: 10
Pages: e25340-e25340
DOI
Related Report
Peer Reviewed
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[Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders.2011
Author(s)
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N.
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Journal Title
Arch Gen Psychiatry
Volume: 68(3)
Pages: 306-313
Related Report
Peer Reviewed
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[Journal Article] Metabolite alterations in the hippocampus of high-functioning adult subjects withautism2010
Author(s)
Suzuki K, Nishimura K, Sugihara G, Nakamura K, Tsuchiya KJ, Matsumoto K,Takebayashi K, Isoda H, Sakahara H, Sugiyama T, Tsujii M, Takei N, Mori N
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Journal Title
Int J Neuropsychopharmacol.
Volume: 13
Pages: 529-534
Related Report
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[Journal Article] Decreased serum levels ofadiponectin in subjects with autism2010
Author(s)
Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M,Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K,Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 34
Pages: 455-458
Related Report
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[Journal Article] Metabolite alterations in the hippocampus of adult subjects with high-functioning autism.2010
Author(s)
Suzuki K, Nishimura K, Sugihara G, Nakamura K, Tsuchiya KJ, Matsumoto K, Takebavashi K, Isoda H, Sakahara H, Sugiyama T, Tsujii M, Takei N, Mori N.
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Journal Title
Int J Neuropsychopharmacol
Volume: 13(4)
Pages: 529-534
Related Report
Peer Reviewed
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