• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A study on the development of biological "veryearly"diagnosis of autism

Research Project

Project/Area Number 22390222
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

MORI Norio  浜松医科大学, 医学部, 教授 (00174376)

Co-Investigator(Kenkyū-buntansha) SUZUKI Katsuaki  浜松医科大学, 医学部, 准教授 (00285040)
TSUCHIYA Kenji  浜松医科大学, 子どものこころの発達研究センター, 准教授 (20362189)
MINOSHIMA Shinsei  浜松医科大学, メディカルフォトニクス研究センター, 教授 (90181966)
MATSUZAKI Hideo  福井大学, 子どものこころの発達研究センター, 教授 (00334970)
NAKAMURA Kazuhiko  弘前大学, 医学系研究科, 教授 (80263911)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Keywords児童・思春期精神医学 / 自閉症 / バイオマーカー / サイトカイン / コホート研究 / Copy number variation
Research Abstract

The aim of the study was to explore biological markers in peripheral plasmasamples from non-medicated subjects with high-functioning ASD.(Experiment 1) A multiplex assay for cytokines and chemokines was applied to plasma samples frommale subjects with high-functioning ASD (n = 28) and matched controls (n = 28). Among a total of 48 analytes examined, theplasma concentrations of IL-1β, IL-1RA, IL-5, IL-8, IL-12(p70), IL-13, IL-17 and GRO-αwere significantly higher in subjects withASD compared with the corresponding values of matched controls after correction for multiple comparisons.(Experiment 2) Plasma levels of 25 amino acids in male children (n= 23) with ASDand matchedcontrols (n= 22) were determined using high-performance liquid chromatography. Compared with controls, subjects with ASD showed higher levels of plasmaglutamate and lower levels of plasma glutamine. Using discriminantanalysis with logistic regression, the two values of plasma glutamate and glutamine were shown to differentiate theASDgroup from the control group; the rate of correct classification was 91%.Theseresults suggest that abnormal immune responses as assessed by multiplex analysis and plasma glutamate and glutamine levelsmay serve as the biological markers for ASD.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (25 results)

All 2013 2012 2011 2010

All Journal Article (21 results) (of which Peer Reviewed: 10 results) Presentation (4 results)

  • [Journal Article] Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism2013

    • Author(s)
      Shimmura C, Suzuki K, Iwata Y, Tsuchiya KJ, Ohno K, Matsuzaki H, Iwata K, Kameno Y, Takahashi T, Wakuda T, Nakamura K, Hashimoto K, Mori N
    • Journal Title

      Mol Autism

      Volume: 4(1) Pages: 6-6

    • Related Report
      2012 Final Research Report
  • [Journal Article] Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism2013

    • Author(s)
      Shimmura C
    • Journal Title

      Molecular Autism

      Volume: 4 Issue: 1 Pages: 6-6

    • DOI

      10.1186/2040-2392-4-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microglial activation in young adults with autism spectrum disorder2013

    • Author(s)
      Suzuki K
    • Journal Title

      JAMA Psychiatry

      Volume: 70 Issue: 1 Pages: 49-58

    • DOI

      10.1001/jamapsychiatry.2013.272

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of the expression of mitochondrial electron transport complex genes in autism brains.2013

    • Author(s)
      Anitha A, Nakamura K, Thanseem I, Matsuzaki H, Miyachi T, Tsujii M, Iwata Y, Suzuki K, Sugiyama T, Mori N.
    • Journal Title

      Brain Pathol.

      Volume: 23 Issue: 3 Pages: 294-302

    • DOI

      10.1111/bpa.12002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocadherin α (PCDHA) as a novel susceptibility gene for autism.2013

    • Author(s)
      Anitha A, Thanseem I, Nakamura K, Yamada K, Iwayama Y, Toyota T, Iwata Y, Suzuki K, Sugiyama T, Tsujii M, Yoshikawa T, Mori N.
    • Journal Title

      J Psychiatry Neurosci.

      Volume: 38 Issue: 3 Pages: 192-198

    • DOI

      10.1503/jpn.120058

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain region-specific altered expression and association of mitochondria-related genes in autism2012

    • Author(s)
      Anitha A, Nakamura K, Thanseem I, Yamada K, Iwayama Y, Toyota T, Matsuzaki H, Miyachi T, Yamada S, Tsujii M, Tsuchiya KJ, Matsumoto K, Iwata Y, Suzuki K, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Mol Autism.

      Volume: 3(1) Pages: 12-12

    • Related Report
      2012 Final Research Report
  • [Journal Article] Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes2012

    • Author(s)
      Thanseem I, Anitha A, Nakamura K, Suda S, Iwata K, Matsuzaki H, Ohtsubo M, Ueki T, Katayama T, Iwata Y, Suzuki K, Minoshima S, Mori N
    • Journal Title

      Biol Psychiatry

      Volume: 71(5) Pages: 410-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Brain region-specific altered expression and association of mitochondria-related genes in autism2012

    • Author(s)
      Anitha A
    • Journal Title

      Molecular Autism

      Volume: 3 Issue: 1 Pages: 12-12

    • DOI

      10.1186/2040-2392-3-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the serum levels of anterior pituitary hormones in male children with autism2011

    • Author(s)
      Iwata K, Matsuzaki H, Miyachi T, Shimmura C, Suda S, Tsuchiya KJ, Matsumoto K, Suzuki K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Sato K, Mori N
    • Journal Title

      Mol Autism

      Volume: 2 Pages: 16-16

    • Related Report
      2012 Final Research Report
  • [Journal Article] Alteration of plasma glutamate and glutamine levels in children with high-functioning autism2011

    • Author(s)
      Shimmura C, Suda S, Tsuchiya KJ, Hashimoto K, Ohno K, Matsuzaki H, Iwata K, Matsumoto K, Wakuda T, Kameno Y, Suzuki K, Tsujii M, Nakamura K, Takei N, Mori N
    • Journal Title

      PLoS One

      Volume: 6(10)

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Association of transcription factor gene LMX1B with autism2011

    • Author(s)
      Thanseem I, Nakamura K, Anitha A, Suda S, Yamada K, Iwayama Y, Toyota T, Tsujii M, Iwata Y, Suzuki K, Matsuzaki H, Iwata K, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      PLoS One

      Volume: 6(8)

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism2011

    • Author(s)
      Suda S, Iwata K, Shimmura C, Kameno Y, Anitha A, Thanseem I, Nakamura K, Matsuzaki H, Tsuchiya KJ, Sugihara G, Iwata Y, Suzuki K, Koizumi K, Higashida H, Takei N, Mori N
    • Journal Title

      Mol Autism

      Volume: 2(1) Pages: 14-14

    • Related Report
      2012 Final Research Report
  • [Journal Article] Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders2011

    • Author(s)
      Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K, Tsuchiya KJ, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Mori N.
    • Journal Title

      PLoS One

      Volume: 6(5)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility2011

    • Author(s)
      Nakamura K, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, YoshikawaT, Mori N
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35(2) Pages: 454-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] The HBC Study Team. Age-specific 3-month cumulative incidence of postpartum depression : The Hamamatsu Birth Cohort (HBC) Study2011

    • Author(s)
      Matsumoto K, Tsuchiya KJ, Itoh H, Kanayama N, Suda S, Matsuzaki H, Iwata Y, Suzuki K, Nakamura K, Mori N, Takei N; The HBC Study Team
    • Journal Title

      Journal of Affective Disorders

      Volume: 133 Issue: 3 Pages: 607-610

    • DOI

      10.1016/j.jad.2011.04.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders2011

    • Author(s)
      Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shinmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K, Tsuchiya KJ, Iwata Y, Nakamura K, Tsujii M, Sugiyama S, Mori N
    • Journal Title

      PLoS One

      Volume: 6(5) Issue: 5 Pages: e20470-e20470

    • DOI

      10.1371/journal.pone.0020470

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence for the role of MET in autism susceptibility2010

    • Author(s)
      Thanseem I, Nakamura K, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, AnithaA, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, Suda S, Kawai M, Sugihara G, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Neurosci Res

      Volume: 68(2) Pages: 137-41

    • Related Report
      2012 Final Research Report
  • [Journal Article] Decreased serum levels ofadiponectin in subjects with autism2010

    • Author(s)
      Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M,Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K,Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34(3) Pages: 455-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Decreased serum levels of adiponectin in subjects with autism.2010

    • Author(s)
      Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiva KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34(3) Pages: 455-458

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, et al.
    • Journal Title

      Neurosci Res

      Volume: 67(2) Pages: 181-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence for the role of MET in autism susceptibility.2010

    • Author(s)
      Thanseem I, Nakamura K, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Anitha A, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, Suda S, Kawai M, Sugihara G, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N.
    • Journal Title

      Neurosci Res

      Volume: 68(2) Pages: 137-141

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 自閉症死後脳縫線核メチル化状態の網羅的解析2012

    • Author(s)
      岩田圭子, 中林一彦, 松崎秀夫, 中村和彦, 秦健一郎, 森則夫
    • Organizer
      第39回日本脳科学会.
    • Place of Presentation
      北九州市
    • Year and Date
      2012-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 自閉症死後脳縫線核メチル化状態の網羅的解析2012

    • Author(s)
      岩田 圭子, 中林 一彦, 松崎 秀夫, 中村 和彦, 秦 健一郎, 森 則夫
    • Organizer
      第39回日本脳科学会
    • Place of Presentation
      北九州市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 「精神障害の予防は可能か?」-自閉症・統合失調症の早期診断と早期介入-2011

    • Author(s)
      森則夫
    • Organizer
      第106回日本小児精神神経学会
    • Place of Presentation
      浜松
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] バイオマーカーからみた自閉症スペクトラム障害2010

    • Author(s)
      鈴木勝昭
    • Organizer
      第104回小児精神神経学会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-14
    • Related Report
      2012 Final Research Report 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi