Analysis of molecular mechanism and the regulation of adhesion
| Project/Area Number |
22390250
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
FUJIMOTO Jiro 兵庫医科大学, 医学部, 教授 (90199373)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Kenji 兵庫医科大学, 医学部, 教授 (60172350)
IIMURO Yuji 兵庫医科大学, 医学部, 教授 (30252018)
HIRANO Tadamichi 兵庫医科大学, 医学部, 講師 (90340968)
UYAMA Naoki 兵庫医科大学, 医学部, 研究生(研究員) (70402873)
YOSHIMOTO Tomohiro 兵庫医科大学, 医学部, 教授 (60241171)
HIROTA Seiichi 兵庫医科大学, 医学部, 教授 (50218856)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 外科総論 / 肝切除後癒着 / NKT細胞 / IFN-γ / PAI-1 / tPA / 肝細胞 / HGF / 癒着形成 / 肝切後 / IFNγ |
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| Research Abstract |
We analyzed the adhesion formation after hepatectomy in mice and humans. After hepatectomy, NKT cells in the liver accumulated nearby cut end and produced IFN-γ. Hepatocyte produced PAI-1, fibrinolysis factor, dependent on IFN-γproduction. These molecules are crucial role for adhesion formation after hepatectomy. Mice treated with recombinant HGF was decreased adhesion formation after hepatectomy though inhibition both IFN-γand PAI-1 production. This treatment may apply for the adhesions in human cases in near future.
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Report
(4 results)
Research Products
(6 results)
