Prevention of early loss of transplanted islets by targeting Na+/Ca2+exchanger of donor islets prior to transplantation
Project/Area Number |
22390251
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Fukuoka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
IWAMOTO Takahiro 福岡大学, 医学部, 教授 (20300973)
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Co-Investigator(Renkei-kenkyūsha) |
TANIGUCHI Masaru 独立行政法人理化学研究所, 免疫制御研究グループ, グループディレクター (80110310)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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Keywords | 移植外科学 / トランスポーター / 膵島移植 / NCX / 膵島細胞死 / 1型糖尿病 / 移植膵島障害 |
Research Abstract |
A major obstacle facing clinical islet transplantation is the low efficiency of this procedure due to innate immune rejection of transplanted islets. In the present study, we demonstrate that the innate immune rejection of transplanted islets is triggered by injury of islet cells caused by Ca2+ influx into 〓 cells via Na+/Ca2+ exchanger (NCX) and that innate immune rejection can be prevented by the treatment of donor islets with NCX inhibitor prior to transplantation.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Pretreatment of donor islets with the Na+/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation.2013
Author(s)
Mera T, Itoh T, Kita S, Kodama S, Kojima D, Nishinakamura H, Okamoto K, Ohkura M, Nakai J, Iyoda T, Iwamoto T, Matsuda T, Baba A, Omori K, Ono J, Watarai H, Taniguchi M, Yasunami Y.
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Journal Title
Am J Transplant
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Assessment of islet quality following international shipping of more than 10,000 km.2010
Author(s)
Ikemoto T, Matsumoto S, Itoh T, Noguchi H, Tamura Y, Jackson AM, Shimoda M, Naziruddin B, Onaca N, Yasunami Y, Levy MF.
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Journal Title
Cell Transplant.
Volume: VOL.19
Pages: 731-741
Related Report
Peer Reviewed
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[Journal Article] Pretreatment of donor islets with the Na+/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation.
Author(s)
Mera T, Itoh T, Kita S, Kodama S, Kojima D, Nishinakamura H, Okamoto K, Ohkura M, Nakai J, Iyoda T, Iwamoto T, Matsuda T, Baba A, Omori K, Ono J, Watarai H, Taniguchi M, Yasunami Y.
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Journal Title
Am J Transplant.
Volume: (In press)
Related Report
Peer Reviewed
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[Presentation] 単離ドナー膵島のNa+/Ca2+交換体を標的にした移植前治療による肝内移植早期膵島障害の新規制御法2013
Author(s)
米良利之,伊東威,喜多紗斗美,小島大望,西中村瞳,永石美晴,小方貴子,金城亜哉,岩本隆宏,小玉正太,安波洋一
Organizer
第40回日本膵・膵島移植研究会
Place of Presentation
高松
Year and Date
2013-03-02
Related Report
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[Presentation] Inhibitory effect of thrombomodulin on HMGB1-stimulated IFN-γ production of hepatic NKT and Gr-1+ Cells, facilitating to prevent early loss of transplanted islets in the liver of mice.2012
Author(s)
Kojima D, Nishinakamura H, Ogata T, Nagaishi M, Mera T, Itoh T, Matsuoka N, Kodama S, Yasunami Y.
Organizer
24th International Congress of the Transplantation society
Place of Presentation
Berlin, Germany
Related Report
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[Presentation] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice.2010
Author(s)
Nobuhide Matsuoka, Takeshi Itoh, Hiroshi Watarai, Etsuko Sekine-Kondo, Naoki Nagata, Kohji Okamoto, Toshiyuki Mera, Hiroshi Yamamoto, Shingo Yamada, Ikuro Maruyama, Masaru Taniguchi, Yohichi Yasunami
Organizer
14th International Congress of Immunology
Place of Presentation
Kobe, Japan
Year and Date
2010-08-27
Related Report
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[Presentation] Actions of the Japanese Society for Pancreas and Islet Transplantation (JSPIT) for recipients of human islets isolated using Liberase HI2010
Author(s)
T.Saito, M.Gotoh, S.Uemoto, T.Kenmochi, Y.Kuroda, Y.Yasunami, S.Satomi, T.Itoh, T.Kitamoto, S.Mohri, S.Teraoka
Organizer
XXIII International Congress of the Transplantation Society
Place of Presentation
Vancouver, Canada
Year and Date
2010-08-16
Related Report
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[Presentation] A Successful Pancreatic Islet Isolation in Cynomolgus Monkeys2010
Author(s)
M.Ogura, M.Watanabe, Y.Koshizuka, D.Kuraya, T.Yoshida, K.Yamashita, H.Kamachi, T.Suzuki, M.Matsushita, Y.Yasunami, S.Todo
Organizer
XXIII International Congress of the Transplantation Society
Place of Presentation
Vancouver, Canada
Year and Date
2010-08-16
Related Report
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