Stratification of gastroenterological tumors by genome-wide analysis of DNA methylation alteration.
| Project/Area Number |
22390255
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KANEDA Atsushi 東京大学, 先端科学技術研究センター, 特任准教授 (10313024)
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
TSUTSUMI Shuichi 東京大学, 先端科学技術研究センター, 特任准教授 (30345152)
UOZAKI Hiroshi 東京大学, 医学部附属病院, 講師 (10296246)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 小腸大腸肛門外科学 / 癌 / エピゲノム / エピジェネティクス / マイクロアレイ / 次世代シーケンサー / 情報工学 |
|---|
| Research Abstract |
DNA methylation analysis on genome-wide scale revealed three distint epigenotypes in gastric cancer and Epstein-Barr virus infection is the cause for extensive DNA methylation epigenotype. As for colorectal cancer, DNA methylation epigenotypes was found to be established already at adenoma stage; serrated adenoma showed high-methylation epigenotype with strong correlation to BRAF mutation, while non-serrated adenoma was classified into intermediate- and low-methylation epigenotypes.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation epigenotypes2011
Author(s)
Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y,Takada K, Aburatani H, Fukayama M
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Journal Title
Cancer Res
Volume: 71(23)
Issue: 23
Pages: 7187-97
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma2010
Author(s)
Deng, Y.B., Nagae, G., Midorikawa, Y., Yagi, K., Tsutsumi, S., Yamamoto, S., Hasegawa, K., Kokudo, N., Aburatani, H., and Kaneda, A
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Journal Title
Cancer Sci
Volume: 101
Pages: 1501-1510
NAID
Related Report
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