| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Research Abstract |
Scirrrhous gastric cancer frequently develops into peritoneal metastasis, resulting in a poor prognosis. Cancer stem cells (CSCs) are considered to be responsible for cancer metastasis. The side population (SP), as evaluated by a flowcytometic analysis has been known as CSCs rich population. The aim of this study is to clarify the characterization of the SP cells in peritoneal metastasis of gastric carcinoma and to determine an effective signal inhibitor with effects on the proliferation of CSC. We used three gastric cancer cell lines and three SP-enriched CSC cell lines. CSCs-like SP cells expressing integrin, and CD44 may play an important role for peritoneal metastasis in gastric carcinoma. CSCs have chemoresistance to irinotecan. c-Met inhibitor may be a promising target molecule for irinotecan-based chemotherapy of gastric cancer. CAFs might regulate the stemness of CSCs in scirrhous gastric cancer by TGF-beta signaling.
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