Development of New technology to Capture Circulating Tumor Cells Using an AC Electric Field

Research Project

Project/Area Number	22390264
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	Akita University
Principal Investigator	OGAWA Jun-ichi 秋田大学, 大学院・医学系研究科, 教授 (20112774)
Co-Investigator(Kenkyū-buntansha)	MINAMIYA Yoshihiro 秋田大学, 大学院・医学系研究科, 准教授 (30239321)
Research Collaborator	AKAGAMI Yo-ichi 秋田県産業技術センター, 部長 NAKAMURA Ryuta 秋田県産業技術センター, 研究員
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000) Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000) Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000) Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords	肺癌 / 血中癌細胞 / EpCAM / 電界 / 血中浮遊がん細胞 / 抗原抗体反応 / 磁性ビーズ / 癌 / 血中浮遊癌細胞
Research Abstract	Cancer cell capture in the blood has been studied in many ways. However, the purity of the cancer cells to be obtained is low and could not be applied in the decision of treatment and diagnosis. This study aimed to develop technologies to get the cancer cells with high purity from the blood. We investigated the recovery rate of cancer cells using an electric field non-contact stirring technique we have developed. However, it was not very good results. This technique was not able to stir the small amount of liquid uniformly. To solve this, we developed a water repellent ring to uniform the stirring. Stirring has become uniform using this ring. Study period was ended, but is continued further studied using this.