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Fundamental study of an anti-adhesive membrane for thoracic surgeries

Research Project

Project/Area Number 22390268
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionYokohama City University

Principal Investigator

NOISHIKI Yasuharu  横浜市立大学, 医学研究科, 特任教授 (60033263)

Co-Investigator(Kenkyū-buntansha) SAWADA Hajime  横浜市立大学, 医学研究科, 教授 (90101112)
ITO Hiroshi  横浜市立大学, 医学研究科, 客員教授 (80124303)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Keywords癒着防止膜 / 外科 / 細胞・組織 / 臨床 / 組織・細胞
Research Abstract

A pilot study for an anti-adhesive membrane for thoracic surgeries especially for the pleural cavity surgery was performed. A biodegradable membrane made of gelatin or hyaluronic-acid containing a certain amount of glycerin was developed. In vivo and in vitro studies showed that the tested membranes were effective to prevent adhesion in the pleural cavity. The mechanism of these desirable results was as follows. The membranes contained glycerin, which gathered and dispersed abundant water. Together with this, growth factors are also dispersed, resulting in dilution of excessive growth factors at the wound sites.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2013 2012 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Elevated m i c r o s a t e l l i t e a l t e r a t i o n s a t selected tetra-nucleotide (EMAST) in non - small cell lung cancers - a potential determinant of susceptibility to multiple malignancies2013

    • Author(s)
      H. Arai, K Okudera, H. Oshiro, N. Komitsu, H. Mitsui, T. Nishi, M. Tsuboi, A. Nozawa, Y. Noishiki, K. Ohhashi, K. Inui,M.Masuda
    • Journal Title

      Int. J. Clin. Exp Patho

      Volume: 6 Pages: 359-410

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated microsatellite alterations at selected tetra-nucleotide (EMAST) in non-small cell lung cancers – a potential determinant of susceptibility to multiple malignancies.2013

    • Author(s)
      H. Arai, et al
    • Journal Title

      Int. J. Clin. Exp Patho

      Volume: 6(3) Pages: 359-410

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] lasmodium induced by SU6656, an Sre family kinase inhibitor、in accompanied by a contractile ring defect.2012

    • Author(s)
      K. Yoshida, M Ono, H Bito, T. Mikami, H.Sawada
    • Journal Title

      Cell Biochem. Func

      Volume: 30 Pages: 33-40

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasmodium induced by SU6656, an Sre family kinase inhibitor, in accompanied by a contractile ring defect.2012

    • Author(s)
      K. Yoshida, et al
    • Journal Title

      Cell Biochem. Func

      Volume: 30(1) Pages: 33-40

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-adhesive membrane for pleural cavity.2010

    • Author(s)
      Y.Noishiki,N. Shintani
    • Journal Title

      Arti Organs

      Volume: 34 Pages: 224-229

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suture Retention Strength of Expanded Polytetrafiuoroethylene(ePTFE)Graft2010

    • Author(s)
      Oshinari Mine, Hideya Mitsui, Yu Oshima, Yasuharu Noishiki, Mikizo Nakai, and Shunji Sano
    • Journal Title

      Acta Med. Okayama

      Volume: 64 Pages: 121-128

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suture Retention Strength of Expanded Polytetrafiuoroethylene(ePTFE) Graft2010

    • Author(s)
      Yoshinari Mine, et al
    • Journal Title

      Acta Med.Okayama

      Volume: 64(2) Pages: 121-128

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-adhesive Membrane for Pleural Cavity2010

    • Author(s)
      Y.noishiki, et al
    • Journal Title

      Artif Organs

      Volume: 34(3) Pages: 224-229

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 細胞の動きを止め、細胞成長因子を拡散させる機能を組み込んだ癒着防止膜2012

    • Author(s)
      野一色泰晴、伊藤博
    • Organizer
      第3回生体由来材料研究会
    • Place of Presentation
      大日精化工業(株)研修センター(東京)
    • Year and Date
      2012-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 癒着防止膜の現状水の動きと細胞の動き2012

    • Author(s)
      野一色泰晴、伊藤博
    • Organizer
      第2回バイオマテリアル基材研究会
    • Place of Presentation
      ハイレックスコーポレーション会
    • Year and Date
      2012-07-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 癒着防止膜の現状。水の動きと細胞の動き2012

    • Author(s)
      野一色泰晴、伊藤博
    • Organizer
      第2回バイオマテリアル基材研究会
    • Place of Presentation
      (株)ハイレックスコーポレーション会議室(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞の動きを止め、細胞成長因子を拡散させる機能を組み込んだ癒着防止膜2012

    • Author(s)
      野一色泰晴、伊藤博
    • Organizer
      第3回生体由来材料研究会
    • Place of Presentation
      大日精化工業(株)研修センター(東京都)
    • Related Report
      2012 Annual Research Report
  • [Remarks] 研究成果は、特許などの権利も絡むので、研究が完了した時点で報告することにしている。そのため論文での報告は行っていない。

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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