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Establishment a therapeutic strategy to children with heart failure

Research Project

Project/Area Number 22390271
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKeio University

Principal Investigator

AEBA Ryo  慶應義塾大学, 医学部, 准教授 (70184025)

Co-Investigator(Kenkyū-buntansha) YOZU Ryohei  慶應義塾大学, 医学部, 講師 (30129738)
UMEZAWA Akihiro  国立成育医療研究センター研究所, 再生医療センター長 (70213486)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords重症心不全 / 細胞治療 / 細胞バンキング / 人工心臓 / 細胞培養 / 細胞バリデーション / 再生医療 / 前臨床研究 / 細胞バリエーション
Outline of Final Research Achievements

It is quite important to accumulate scientific data, promote science-based industrial development and harmonize regulatory issues for cell-based therapy in pediatric cardiology. However, heart transplantation, artificial device, and cell-based therapy have been applied to adult patients with severe heart failure, but not to pediatric patients. In this study, we aim to establish a therapeutic strategy to children with heart failure, and provide the important areas of cell-based therapy with somatic cells such as skeletal myocytes and cardiomyocytes under both the Medical affairs law and Pharmaceutical affairs law. This study addresses critical issues in the field, exchanges new ideas and disseminates the latest developments in basic research and clinical translation focusing on cell-based therapy to patients with heart failure.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(40 results)

All 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

  • [Journal Article] Positional desaturation due to persistent left superior vena cava draining into the left atrium.2015

    • Author(s)
      Shirakawa K, Kawamura A, Muraoka N, Murata M, Tsuruta H, AEBA R, Fukuda K
    • Journal Title

      Heart and Vessels

      Volume: Epub ahead of print

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative pressure therapy for post-sternotomy wound infections in young children.2014

    • Author(s)
      Kawajiri H, AEBA R (corresponding author), Takaki H, Yozu R, Iwata S
    • Journal Title

      Inter Cardiovasc Thorac Surg.

      Volume: 19 Pages: 102-106

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MiR-133 Promotes Cardiac Reprogramming by Directly Repressing Snai1 and Silencing Fibroblast.2014

    • Author(s)
      Muraoka N, Yamakawa H, Miyaoto K, Sadahiro T, Umei T, Isomi M, Nakashima H, Akiyama M, Wada R, Inagawa K, Nishiyama T, Kaneda R, Fukuda T, Takada S, Tohyama S, Hashimoto H, Kawamura Y, Goshima N, AEBA R, Yamagishi H, Fukuda K, Ieda M.
    • Journal Title

      EMBO

      Volume: 33 Pages: 1565-1581

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fontan completion in a patient with previous liver transplantation.2014

    • Author(s)
      Haida H, AEBA R (corresponding author), Hoshino K, Morikawa Y.
    • Journal Title

      Inter Cardiovasc Thorac Surg.

      Volume: 19 Pages: 705-707

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative pressure therapy for post-sternotomy wound infections in young children.2014

    • Author(s)
      Kawajiri H, Aeba R, Takaki H, Yozu R, Iwata S.
    • Journal Title

      Interact Cardiovasc Thorac Surg

      Volume: 1111 Pages: 1111-1111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.2013

    • Author(s)
      Wada R, Muraoka N, Inagawa K, Yamakawa H, Miyamoto K, Sadahiro T, Umei T,
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110(31) Pages: 12667-72

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral banding of malpositioned pulmonary artery branches.2013

    • Author(s)
      Aeba R, Kotani S, Yamabe K, Yozu R.
    • Journal Title

      Pediatr Cardiol

      Volume: 34(8) Pages: 1938-40

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale cell production of stem cells for clinical application using the automated cell processing machine.2013

    • Author(s)
      Daisuke Kami1, Keizo Watakabe, Mayu Yamazaki-Inoue, Kahori Minami,Tomoya Kitani, Yoko Itakura, Masashi Toyoda, Takashi Sakurai, Akihiro Umezawa and Satoshi Gojo.
    • Journal Title

      BMC Biotechnology 2013

      Volume: 13(1) Pages: 102-102

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia2012

    • Author(s)
      Kimura M TM, Gojo S, Itakura Y, Kami D, Miyoshi S, Kyo S, Ono M,Umezawa A.
    • Journal Title

      J.Stem Cells.Regen.Med

      Volume: 8(3) Pages: 171-180

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bridging annuloplasty for left atrioventricular valve of partial atrioventricular septal defect2012

    • Author(s)
      Aeba R, Kudo M, Okamoto K, Yozu R
    • Journal Title

      Ann Thorac Surg

      Volume: 93(5) Pages: 137-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extra-anatomic pulmonary artery bypass for main pulmonary artery stenosis caused by neoplasm2012

    • Author(s)
      Aeba R, Nomori H, Yozu R
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 144(1) Pages: 10-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Right ventricle-pulmonary artery conduit with intake port in the Norwood procedure2012

    • Author(s)
      Aeba R, Yozu R
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 144(5) Pages: 1260-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral Banding of Malpositioned Pulmonary Artery Branches.2012

    • Author(s)
      Aeba R, Kotani S, Yamabe K, Yozu R.
    • Journal Title

      Pediatr Cardiol

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extra-anatomic pulmonary artery bypass for main pulmonary artery stenosis due to neoplasm2012

    • Author(s)
      AEBA R, Nomori H, Yozu R
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: (accepted for publication)(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bridging annuloplasty for left atrioventricular valve of partial atrioven tricular septal defect2012

    • Author(s)
      AEBA R, Kudo M, Okamoto K, Yozu R
    • Journal Title

      Ann Thorac Surg

      Volume: 93(5)(accepted for publication) Pages: 137-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue engineering and cell-based therapy toward integrated strategy with artificial organs2011

    • Author(s)
      Gojo S, Toyoda M, Umezawa A
    • Journal Title

      J Artif Organs

      Volume: 14(3) Pages: 171-7

    • NAID

      10030338842

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心臓手術の実際外科医が語る術式、麻酔科医が語る心臓麻酔、臨床工学技士が語る体外循環法(第19回)低侵襲心臓外科手術(MICS)における体外循環法2011

    • Author(s)
      根本淳, 四津良平, 山田達也, 又吉徹
    • Journal Title

      Clinical Engineering

      Volume: 22巻11号 Pages: 1069-1077

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Open anastomosis of extracardiac conduit for total cavopulmonary connection decreases post-operative pleural effusion.2010

    • Author(s)
      Aeba R
    • Journal Title

      Cardiol Young.

      Volume: 20(6) Pages: 686-691

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fenestrated exclusion of the right ventricle for tricuspid atresia and absent pulmonary valve.2010

    • Author(s)
      Kasahara H
    • Journal Title

      Ann Thorac Surg.

      Volume: 90(2) Pages: 647-649

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ross-Konno operation for patients with Shone complex.2010

    • Author(s)
      Aeba R
    • Journal Title

      Tex Heart Inst J

      Volume: 37(2) Pages: 240-241

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 先天性胆道閉鎖•生体肝移植後にTCPSを行い、TCPC completionに成功した内蔵錯位症候群(続報)2014

    • Author(s)
      小柳喬幸,  住友直文, 荒木耕生,  石崎怜奈 , 柴田映道, 河野一樹, 前田潤, 福島裕之, 饗庭 了, 山岸敬幸
    • Organizer
      第50回日本小児循環器学会総会. 学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2014-07-03 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小児心臓外科における補助手段の進歩と低侵襲化。Fontan手術の低侵襲下に貢献する補助手段2013

    • Author(s)
      饗庭 了、四津良平
    • Organizer
      第43回日本心臓血管外科学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 私の“こだわりの”手術手技:Complete AVSDに体する術式。私の“こだわりの”手術手技:Complete AVSDに対する術式2013

    • Author(s)
      饗庭 了、四津良平
    • Organizer
      第43回日本心臓血管外科学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小児開心術後の縦隔炎に対するvacuum assisted closure2012

    • Author(s)
      河尻拓之, 饗庭了, 伊藤隆仁, 北原大翔, 高木秀暢, 灰田周史, 小谷聡秀, 岡本一真, 吉武明弘, 四津良平
    • Organizer
      第42回日本心臓血管外科学会学術総会
    • Place of Presentation
      秋田秋田キャッスルホテル
    • Year and Date
      2012-04-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rechallenge of patients originally contraindicated for the Fonatan procedure2012

    • Author(s)
      AEBA R, Kotani S, Yozu R
    • Organizer
      The 20th Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery
    • Place of Presentation
      Nusa Dua, Bali, Indonesia
    • Year and Date
      2012-03-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小児開心術後の縦隔炎に対するvacuum assisted closure2012

    • Author(s)
      河尻拓之、饗庭了、伊藤隆仁、北原大翔、高木秀暢、灰田周史、小谷聡秀、岡本一真、吉武明弘、四津良平
    • Organizer
      第42回日本心臓血管外科学会学術総会
    • Place of Presentation
      秋田
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ross手術後遠隔期に心室細動を起こし冠動脈狭窄が発見された1例2012

    • Author(s)
      石崎怜奈、宮原瑤子、安田幹、小柳喬幸、柴田映道、河野一樹、古道一樹、前田潤、福島裕之、饗庭了、山岸敬幸、示説
    • Organizer
      第48回日本小児循環器学会総会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 先天性胆道閉鎖・生体肝移植後にTCPSを行った内蔵錯位症候群の症例2012

    • Author(s)
      小柳喬幸, 柴田映道, 潟山亮平,  古道一樹, 河野一樹, 下島直樹, 前田潤, 福島裕之,黒田達夫, 饗庭 了, 山岸敬幸. 示説
    • Organizer
      第48回日本小児循環器学会総会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bridging annuloplasty for left atrioventricular valve of partial atrioventricular septal defect.2012

    • Author(s)
      AEBA R, Kudo M, Okamoto K, Yozu R
    • Organizer
      The American Association for Thoracic Surgery. Mitral Conclave Japan 2012
    • Place of Presentation
      長野
    • Related Report
      2012 Annual Research Report
  • [Presentation] Case report award. 重症先天性心肝疾患に対するmultidisciplinary approachによる1救命例:世界初の生体肝移植後のTCPS手術2012

    • Author(s)
      灰田周史、饗庭了、伊藤隆仁、高木秀暢、四津良平
    • Organizer
      第65回日本胸部外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 適応拡大に伴って施行された成人期Fontan型手術の成績2011

    • Author(s)
      小谷聡秀, 饗庭了, 河尻拓之, 根本淳, 山邊健太郎, 四津良平
    • Organizer
      第64回日本胸部外科学会総会
    • Place of Presentation
      愛知名古屋国際会議場
    • Year and Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Second generation"loop-techniqueによる右小開胸僧帽弁形成術2011

    • Author(s)
      岡本一真, 工藤樹彦, 四津良平
    • Organizer
      第64回日本胸部外科学会定期学術集会
    • Place of Presentation
      愛知名古屋国際会議場
    • Year and Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] "loop technique"を用いた僧帽弁形成術-210症例の検討-2011

    • Author(s)
      工藤樹彦、四津良平、岡本一真、古梶清和、根本淳、山邉健太朗、河尻拓之
    • Organizer
      第64回日本胸部外科学会定期学術集会
    • Place of Presentation
      愛知名古屋国際会議場
    • Year and Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新しい心臓手術:ポートアクセス法500例の経験2011

    • Author(s)
      四津良平
    • Organizer
      第9回永山循環器セミナー
    • Place of Presentation
      東京日本医科大学多摩永山病院
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Loop's Technique for Mitral Valve Repair2011

    • Author(s)
      Ryohei Yozu
    • Organizer
      ASCVTS-ATCSA 2011 Joint Meeting of 19thAS CVTS and 21stATCSA
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2011-05-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ASD CLOSURE VIA ENDSCOPICASSISTED MINI-THORACOTOMY APPROACH2011

    • Author(s)
      Kazuma Okamoto, Mikihiko Kudo, Ryohei Yozu
    • Organizer
      ASCVTS-ATCSA 2011 Joint Meeting of 19th ASCVTS and 21st ATCSA
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Minimally invasive mitral valve surgery on a routine basis2011

    • Author(s)
      四津良平, 工藤樹彦, 岡本一真, 古梶清和, 根本淳, 山邉健太朗
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      (紙上開催)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] New Innovative Instruments Facilitate Both Direct-Vision AndEndoscopic-Assisted Mini-Mitral Valve Surgery2011

    • Author(s)
      Ryohei Yozu
    • Organizer
      Mitral Conclave 2011
    • Place of Presentation
      New York, U.S.A
    • Year and Date
      2011-05-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高度ASと慢性腎不全を併存する腹部大動脈瘤に対し、BAVとEVARを二期的に施行した超高齢者の一治験例2011

    • Author(s)
      古田晃, 志水秀行, 蜂谷貢, 古梶清和, 工藤樹彦, 饗庭了, クリビエラン, 福田恵一, 四津良平
    • Organizer
      第39回日本血管外科学会学術総会
    • Place of Presentation
      沖縄沖縄コンベンションセンターラグナガーデンホテル
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] New innovations of instruments and techniques facilitate endoscopic assisted mitral valve repair via minithoracotomy2011

    • Author(s)
      Kazuma Okamoto, MikihikoKudo, David Adams, Ryohei Yozu
    • Organizer
      Annual Scientific Meeting of The International Society for Minimally InvasiveCardiothoracic Surgery
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-22   Modified: 2019-07-29  

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