Identification of transcription factors that regulate tendon/ligament formation
Project/Area Number |
22390289
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Kyoto University |
Principal Investigator |
SHUKUNAMI Chisa 京都大学, 再生医科学研究所, 准教授 (60303905)
|
Research Collaborator |
SUGIMOTO Yuki 京都大学, 再生医科学研究所, 研究生
SHIMAMURA Satoko 京都大学, 再生医科学研究所, 大学院生
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
Keywords | 転写因子 / Tenomodulin / 腱 / 靱帯 / 運動器 / enhancer / 靭帯 / tenomodulin |
Research Abstract |
Mouse Tenomodulin (Tnmd)is predominantly expressed in dense connective tissues such as tendons and ligaments. We identified the enhancer regions near the promoter and within the intron 2 of the mouseTnmdgene. We found that these enhancer regionsare transactivated by the transcription factors of basic helix-loop-helix, Ets, or Sox family.
|
Report
(4 results)
Research Products
(25 results)
-
-
[Journal Article] Tenomodulin expression in the periodontal ligament enhances cellular adhesion2013
Author(s)
Y. Komiyama, S. Ohba, N. Shimohata, K. Nakajima, H. Hojo, F. Yano, T. Takato, D. Docheva, C. Shukunami, Y. Hiraki, and UI. Chung.
-
Journal Title
PLoS One
Volume: 8
Issue: 4
Pages: e60203-e60203
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 腱・靭帯の形成と再生2011
Author(s)
宿南知佐
Organizer
第26回に本整形外科学基礎学術集会(招待講演)
Place of Presentation
群馬県民会館、群馬
Year and Date
2011-10-21
Related Report
-
[Presentation] 腱・靭帯の形成と再生2011
Author(s)
宿南知佐
Organizer
第26回日本整形外科学会基礎学術集会
Place of Presentation
前橋(群馬県民会館)(招待講演)
Year and Date
2011-10-21
Related Report
-
[Presentation] 腱・靱帯形成の制御2011
Author(s)
宿南知佐
Organizer
第18回プロテオグライカンフォーラム
Place of Presentation
東京医科歯科大学(招待)
Year and Date
2011-02-19
Related Report
-
[Presentation] 腱・靭帯形成の制御2011
Author(s)
宿南知佐
Organizer
第18回プロテオグリカンフォーラム(招待講演)
Place of Presentation
東京医科歯科大学、東京
Year and Date
2011-02-09
Related Report
-
-
-
-
-
-