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A study of the ameliorative activity of 2-decenoic acid ester derivatives on the spinal cord injury and its medical application

Research Project

Project/Area Number 22390293
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionGifu Pharmaceutical University

Principal Investigator

FURUKAWA Shoei  岐阜薬科大学, 薬学部, 教授 (90159129)

Co-Investigator(Kenkyū-buntansha) FUKUMITSU Hidefumi  岐阜薬科大学, 薬学部, 准教授 (00308280)
SOUMIYA Hitomi  岐阜薬科大学, 薬学部, 助教 (20548713)
FURUKAWA Yoshiko  松山大学, 薬学部, 教授 (20219108)
IINUMA Munekazu  岐阜薬科大学, 薬学部, 教授 (70082998)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Keywords脊髄損傷 / 軸索再生 / 運動機能回復 / デセン酸誘導体 / 神経栄養因子 / シグナル伝達 / 培養神経細胞 / 神経再生 / 遺伝子発現
Research Abstract

Oral administration of (E)-N-2-(dimethylamino) ethyl dec-2-enamide, a novel 2-decenoic acid compound, to the rats with a complete transection of the spinal cord injury, markedly improved locomotor activity after 3 weeks. The animals treated with the compound could nearly walk sustaining their weight in hind limb, but the control ones without treatment remained unchanged, demonstrating that the locomotor function impaired following the spinal cord injury could be markedly recovered by oral administration of the 2-decenoic acid derivatives.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (51 results)

All 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 8 results) Presentation (20 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 2 results)

  • [Journal Article] Medium-chain fatty acid-containing dietary oil alleviates the depression-like behaviour in mice exposed to stress due to chronic forced swimming.2013

    • Author(s)
      Shinohara H
    • Journal Title

      J. Funct Foods

      Volume: 5 Pages: 601-606

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Injury-induced accumula- tion of glial cell line-derived neuro- trophic factor in the rostral part of the injured rat spinal cord2012

    • Author(s)
      Hara T, Fukumitsu H, Soumiya H, Furukawa Y, Furukawa S
    • Journal Title

      Int J Mol Sci

      Volume: 13 Issue: 10 Pages: 13484-13500

    • DOI

      10.3390/ijms131013484

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2-Decenoic acid ethyl ester, a compound that elicits neurotrophin-like intracellular signals, facilitating functional recovery from cerebral infarction in mice.2012

    • Author(s)
      Tanaka Y
    • Journal Title

      Int J Mol Sci

      Volume: 13 Issue: 4 Pages: 4968-4981

    • DOI

      10.3390/ijms13044968

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of pre-mRNA cleavage factor Im 25kDa promotes neurite outgrowth2012

    • Author(s)
      Fukumitsu H, Soumiya H, Furukawa S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 425 Issue: 4 Pages: 848-853

    • DOI

      10.1016/j.bbrc.2012.07.164

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antidepressant-like activity of 10-hydroxy-trans-2-decenoic acid, a unique unsaturated fatty acid of royal jelly, in stress-inducible depression-like mouse model2012

    • Author(s)
      Ito S, Nitta Y, Fukumitsu H, Soumiya H, Ikeno K, Nakamura T, Furukawa S
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: 2012 Pages: 139140-139140

    • Related Report
      2012 Final Research Report
  • [Journal Article] Caffeic acid phenethyl ester reduces spinal cord injury-evoked locomotor dysfunction2011

    • Author(s)
      Kasai M, Fukumitsu H, Soumiya H,Furukawa S
    • Journal Title

      Biomed Res

      Volume: 32 Pages: 1-7

    • NAID

      130004903812

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Prenatal immune challenge compromises development of upper-layer but not deeper-layer neurons of the mouse cerebral cortex2011

    • Author(s)
      Soumiya H, Fukumitsu H, Furukawa S
    • Journal Title

      J Neurosci Res

      Volume: 89 Issue: 9 Pages: 1342-1350

    • DOI

      10.1002/jnr.22636

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Prenatal immune challenge compromises the normal course of neurogenesis during development of the mouse cerebral cortex2011

    • Author(s)
      Soumiya H, Fukumitsu H, Furukawa S
    • Journal Title

      J Neurosci Res

      Volume: 89 Issue: 10 Pages: 1575-1585

    • DOI

      10.1002/jnr.22704

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A superoxide anion-scavenger,1,3-selenazolidin-4-one suppresses serum deprivationinduced apoptosis in PC12 cells by activating MAP kinase2011

    • Author(s)
      Nishina A, Kimura H, Kozawa K, Sommen G, Nakamura T, Heimgartner H, Koketsu M, Furukawa S
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 257 Pages: 388-395

    • Related Report
      2012 Final Research Report
  • [Journal Article] 3-(2,6-Dimethylphenyl)-2-selenoxo-1,3-thiazolidin-4-one suppresses hydrogen peroxide-induced cytotoxicity on PC12 cells via activation of MAPK2011

    • Author(s)
      Nishina A, Kimura H, Kozawa K, Sommen G, Favero F, Heimgartner H, Koketsu M, Furukawa S
    • Journal Title

      Int J Toxicol

      Volume: 30 Pages: 690-699

    • Related Report
      2012 Final Research Report
  • [Journal Article] Ethanol extract of chinese propolis facilitates functional recovery of locomotor activity after spinal cord injury2011

    • Author(s)
      Kasai M, Fukumitsu H, Soumiya H, Furukawa S
    • Journal Title

      Evid Based Complement Alternat Med.

      Volume: 2011

    • Related Report
      2012 Final Research Report
  • [Journal Article] 4-Methylcatechol- induced heme oxygenase-1 exerts a protective effect against oxidative stress in cultured neural stem/progenitor cells via PI3 kinase/Akt pathway2010

    • Author(s)
      Furukawa Y, Urano T, Minamimura M, Nakajima M, Okuyama S, Furukawa S
    • Journal Title

      Biomed Res

      Volume: 31 Pages: 45-52

    • NAID

      130004903782

    • Related Report
      2012 Final Research Report
  • [Journal Article] FGF-2-responsive and spinal cord-resident cells improve locomotor function after spinal cord injury2010

    • Author(s)
      Kasai M, Jikoh T, Fukumitsu H, Furukawa S.
    • Journal Title

      Jneurotrauma

    • Related Report
      2012 Final Research Report
  • [Journal Article] Targeted retrograde gene delivery of brain-derived neurotrophic factor suppresses apoptosis of neurons and oligodendroglia after spinal cord injury in rats2010

    • Author(s)
      Nakajima H, Uchida K, Yayama T, Kobayashi S, Guerrero AR, Furukawa S, Baba H
    • Journal Title

      Spine

      Volume: 35 Pages: 497-504

    • NAID

      10028062172

    • Related Report
      2012 Final Research Report
  • [Journal Article] 2-Decenoic acid ethyl ester, a derivative of unsaturated mediumchain fatty acids, facilitates functional recovery of locomotor activity after spinal cord injury2010

    • Author(s)
      Hirakawa A, Shimizu K, Fukumitsu H, Soumiya H, Iinuma M, Furukawa S
    • Journal Title

      Neuroscience

      Volume: 171 Issue: 4 Pages: 1377-1385

    • DOI

      10.1016/j.neuroscience.2010.10.004

    • Related Report
      2012 Final Research Report
  • [Journal Article] Estrogen Stimulates Proliferation and Differentiation of Neural Stem/Progenitor Cells through Different Signal Transduction Pathways2010

    • Author(s)
      Okada M, Makino A, Nakajima M, Okuyama S, Furukawa S, Furukawa Y.
    • Journal Title

      Int J Mol Sci

      Volume: 11 Pages: 4114-4123

    • Related Report
      2012 Final Research Report
  • [Journal Article] 2-Decenoic acid ethyl ester possesses neurotrophin-like activities to facilitate intracellular signals and increase synapse-specific proteins in neurons cultured from embryonic rat brain2010

    • Author(s)
      Makino A, Iinuma M, Fukumitsu H, Soumiya H, Furukawa Y, Furukawa S
    • Journal Title

      Biomed Res

      Volume: 31 Pages: 379-386

    • NAID

      130004470765

    • Related Report
      2012 Final Research Report
  • [Journal Article] FGF-2-responsive and spinal cord-resident cells improve locomotor function after spinal cord injury.2010

    • Author(s)
      Kasai M, Jikoh T, Fukumitsu H, Furukawa S
    • Journal Title

      J Neurotrauma

      Volume: Mar 3(Epub ahead of print) Pages: 20199141-20199141

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-Decenoic acid ethyl ester, a derivative of unsaturated medium-chain fatty acids, facilitates functional recovery of locomotor activity after spinal cord injury.2010

    • Author(s)
      Hirakawa A, Shimizu K, Fukumitsu H, Soumiya H, Iinuma M, Furukawa S.
    • Journal Title

      Neuroscience

      Volume: 171(4) Pages: 1377-1385

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethanol extract of chinese propolis facilitates functional recovery of locomotor activity after spinal cord injury.2010

    • Author(s)
      Kasai M, Fukumitsu H, Soumiya H, Furukawa S.
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: 2010 Sep 8(Epub) Pages: 749627-749627

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] コルチコステロン慢性投与によるうつ病モデル動物の作製とそれを用いたデセン酸誘導体の活性評価2013

    • Author(s)
      柴田翔洋ら
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 手がかり学習における脳由来神経栄養因子の役割に関する研究2013

    • Author(s)
      影山耕太ら
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] プロポリスによる脊髄損傷の修復2013

    • Author(s)
      古川昭栄
    • Organizer
      第1回ファイトケミカル研究会-機能性食品への展開
    • Place of Presentation
      岐阜
    • Year and Date
      2013-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経栄養因子シグナルの活性化に基づく新規アルツハイマー病治療薬(新規デセン酸誘導体)2013

    • Author(s)
      古川昭栄
    • Organizer
      創薬シーズ・基盤技術アラアンスネットワーク疾患別商談会
    • Place of Presentation
      大阪
    • Year and Date
      2013-02-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 手がかり学習における脳由来神経栄養因子の役割に関する研究2013

    • Author(s)
      影山耕太
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] コルチコステロンの慢性投与によるうつ病モデル動物の作製とそれを用いたデセン酸誘導体の活性評価2013

    • Author(s)
      柴田翔洋
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 生後直後の感覚入力遮断がマウスの社会性行動と情動機能に及ぼす影響2012

    • Author(s)
      荒磯ひろみら
    • Organizer
      日本病院薬剤師東海ブロック・日本薬学会東海支部合同学術大会2012
    • Place of Presentation
      岐阜
    • Year and Date
      2012-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Amelioration of locomotor dysfunction after spinal cord injury by orally-administered 2-decenoic acid derivatives2012

    • Author(s)
      Ushiro D et al
    • Organizer
      第55回日本神経化学会
    • Place of Presentation
      神戸
    • Year and Date
      2012-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 2-デセン酸誘導体による脊髄損傷修復について2012

    • Author(s)
      後大輔ら
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] ピーナツ渋皮抽出物の抗うつ様作用2012

    • Author(s)
      森大輔、古川昭栄
    • Organizer
      日本農芸化学会 2012年度大会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] カフェイン酸フェネチルエステル(CAPE)の抗うつ作用2012

    • Author(s)
      古川昭栄ら
    • Organizer
      第3回岐阜薬科大学機能性健康食品研究講演会
    • Place of Presentation
      岐阜
    • Year and Date
      2012-02-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Morphology of neuronal cells is modified by pre-mRNA cleavage factor Im.2012

    • Author(s)
      Fukumitsu H
    • Organizer
      第55回日本神経化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Amelioration of locomotor dysfunction after spinal cord injury by orally-administered 2-decenoic acid derivatives.2012

    • Author(s)
      Ushiro D
    • Organizer
      第55回日本神経化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of whisker-trimming during the perinatal period on behavior of mice.2012

    • Author(s)
      Araiso H
    • Organizer
      第55回日本神経化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大豆ソヤサポニンによる脊髄損傷修復2011

    • Author(s)
      樹下洋輔ら
    • Organizer
      第2回岐阜薬科大学機能性健康食品研究講演会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ピーナッツ渋皮抽出物のアルツハイマー病予防作用に関する研究2011

    • Author(s)
      森大輔ら
    • Organizer
      第2回岐阜薬科大学機能性健康食品研究講演会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] PQQ の脳内マップキナーゼ活性化作用と抗うつ効果2011

    • Author(s)
      虎谷厚志ら
    • Organizer
      第2回岐阜薬科大学機能性健康食品研究講演会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 大豆成分ソヤサポニンの腹腔内投与による脊髄損傷修復2011

    • Author(s)
      樹下洋輔ら
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] FGF-2 induced fibronectin-positive cells retained the potential to repair spinal cord injury through several passages2010

    • Author(s)
      Kasai M et al
    • Organizer
      第53回日本神経化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Therapeutic effects of soybean isoflavone equol on depression of animal model via the activation of brain MAP kinases.2010

    • Author(s)
      Itoh S et al
    • Organizer
      第53回日本神経化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2012 Final Research Report
  • [Book] Propolis: Implications for the treatment of spinal cord injuries.in "Beneficial effects of propolis on human chronic diseases"2012

    • Author(s)
      Furukawa S, Kasai M, Fukumitsu H, Soumiya H, Furukawa Y
    • Publisher
      Tahira Farooqui, Akhlaq A.Farooqui, Nova Science Publishers
    • Related Report
      2012 Final Research Report
  • [Book] 5.増殖因子4)Neurotrophins. 臨床免疫・アレルギー科2012

    • Author(s)
      古川昭栄、福光秀文、古川美子
    • Publisher
      サイトカインのすべて
    • Related Report
      2012 Final Research Report
  • [Book] 臨床免疫・アレルギー科、サイトカインのすべて2012

    • Author(s)
      古川昭栄(分担執筆)
    • Total Pages
      861
    • Publisher
      科学評論社
    • Related Report
      2012 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.gifu-pu.ac.jp/research/research_bunsei.html

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 4-過酸化-トランス-2-デセン酸誘導体及びこれを含有する医薬2013

    • Inventor(s)
      飯沼宗和、古川昭栄、伊藤彰近
    • Industrial Property Rights Holder
      飯沼宗和、古川昭栄、伊藤彰近
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-054194
    • Filing Date
      2013-03-15
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] トランス-2-デセン酸誘導体及びこれを含有する医薬2012

    • Inventor(s)
      飯沼宗和、古川昭栄、内木充、松元智規、杉本八郎
    • Industrial Property Rights Holder
      中部 TLO、日本臓器株式会社
    • Industrial Property Number
      2012-513796
    • Acquisition Date
      2012-07-20
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 抗がん剤による末梢神経障害の予防又は治療剤2012

    • Inventor(s)
      飯沼宗和、古川昭栄、内木充、岡田智行、松元智規、澤田和好
    • Industrial Property Rights Holder
      中部 TLO、日本臓器株式会社
    • Industrial Property Number
      2012-516241
    • Acquisition Date
      2012-06-08
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 鎮痛剤2012

    • Inventor(s)
      飯沼宗和、古川昭栄、内木充、岡田智行、松元智規、澤田和好
    • Industrial Property Rights Holder
      中部 TLO、日本臓器株式会社
    • Industrial Property Number
      2012-516240
    • Acquisition Date
      2012-06-08
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] PCT 出願「トランス-2-デセン酸誘導体及びこれを含有する医薬」2011

    • Inventor(s)
      飯沼宗和、古川昭栄
    • Industrial Property Rights Holder
      中部 TLO
    • Filing Date
      2011-11-01
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許出願2011

    • Inventor(s)
      飯沼宗和、古川昭栄, 他3名
    • Industrial Property Rights Holder
      中部TLO日本臓器製薬
    • Filing Date
      2011-11-01
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許出願2010

    • Inventor(s)
      飯沼宗和、古川昭栄
    • Industrial Property Rights Holder
      名古屋産業科学研究所
    • Industrial Property Number
      2010-246503
    • Filing Date
      2010-11-03
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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