Investigations into the role of uro-genital interstitial cells as a metabolic sensor in physiology and disease
| Project/Area Number |
22390304
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
HASHITANI Hikaru 名古屋市立大学, 大学院・医学研究科, 教授 (10315905)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Hikaru 名古屋市立大学, 大学院・医学研究科, 名誉教授 (80037548)
KUBOTA Yasue 名古屋市立大学, 大学院・医学研究科, 講師 (00381830)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
MITSUI Retsu 名古屋市立大学, 大学院・医学研究科, 助教 (90434092)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMURO Terumasa 早稲田大学, 人間科学学術院, 名誉教授 (20037386)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 間質細胞 / ミトコンドリア / ペリサイト / 平滑筋 / 細胞内カルシウムオシレーター / 電位依存性 / 微小循環 / 過活動膀胱 / 細胞内カルシウム / 自発活動 / 細胞代謝 / 下部尿路症状 / メタボリック症候群 / 虚血 |
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| Research Abstract |
Perinuclear mitochondria in interstitial cells may regulate endoplasmic reticulum Ca^<2+> release by buffering Ca^<2+> within microdomains between both organelles, and play a dominant role in the spatial regulation of Ca^<2+> wave generation. Pericytes in bladder suburothelium generate spontaneous Ca^<2+> transients and associatedcontractions relying on cytosolic Ca^<2+> oscillator and voltage-dependent synchrony, and thus may function as active drainage machinery of tissue metabolites.
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Report
(4 results)
Research Products
(70 results)
