• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Tailor-made medicine based on genetic polymorphism analyses in relation to biological and immunological responses

Research Project

Project/Area Number 22390335
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionChiba University

Principal Investigator

ODA Shigeto  千葉大学, 大学院・医学研究院, 教授 (90204205)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords生体反応 / 遺伝子多型 / DNAアレイ / 表現型 / サイトカイン / 個別化治療
Research Abstract

This study aims to establish the tailor-made medicine based on genetic polymorphism analysis in Japanese population. To determine the genetic effects on pathophysiology of severe sepsis, we investigated whether IL-1RA 2nd intron variable number of tandem repeat (VNTR) polymorphism bears influences on the susceptibility to and the outcome of severe sepsis. And, we also evaluated association between the VNTR and ex vivo expression of cytokines. Two hundred and sixty one patients who had admitted to an ICU (intensive care unit) were enrolled into a discovery cohort and 793 ICU patients admitted to the 5 different institutes were enrolled into a validation cohort. The IL1RA RN^*2, which was suggested to be a less IL-1ra producer, was associated with adverse outcome of severe sepsis via lower regulatory potential against some inflammatory cytokine production in Japanese population.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (14 results)

  • [Journal Article] 敗血症の転帰に影響を与える遺伝子多型2013

    • Author(s)
      島田忠長,中田孝明,織田成人
    • Journal Title

      日救急医会誌

      Volume: 24 Pages: 1-11

    • NAID

      130004840941

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients2012

    • Author(s)
      Watanabe E, Zehnbauer BA, Oda S, Sato Y, Hirasawa H, Buchman TG
    • Journal Title

      Cytokine

      Volume: 60 Pages: 249-56

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体反応と個体差;遺伝子多型と性差2012

    • Author(s)
      渡邉栄三
    • Journal Title

      救急医学

      Volume: 36 Pages: 1110-1115

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 遺伝子多型と生体反応-全身性炎症反応症候群(SIRS)関連疾患のゲノム情報によるテーラーメード医療実践へ向けて-特集:侵襲に対する生体反応の個体差2011

    • Author(s)
      渡邉栄三,木村友則,織田成人
    • Journal Title

      侵襲と免疫

      Volume: 20 Pages: 69-77

    • Related Report
      2012 Final Research Report
  • [Journal Article] 遺伝子多型と生体反応-全身性炎症反応症候群(SIRS)関連疾患のゲノム情報によるテーラーメード医療実践へ向けて-特集:侵襲に対する生体反応の個体差2011

    • Author(s)
      渡邊栄三, 木村友則, 織田成人
    • Journal Title

      侵襲と免疫

      Volume: 20 Pages: 67-77

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Outcome prediction in sepsis combined use of genetic polymorphisms-A study in Japanese Population2011

    • Author(s)
      Shimada T, Oda S, Sadahiro T, et al
    • Journal Title

      Cytokine

      Volume: 54 Pages: 79-84

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子多型と生体反応.特集:生体防御と自然免疫-最近の知見-2010

    • Author(s)
      渡邉栄三,織田成人,島田忠長
    • Journal Title

      侵襲と免疫

      Volume: 19 Pages: 87-90

    • Related Report
      2012 Final Research Report
  • [Presentation] インターロイキン(IL-1)関連遺伝子多型のsepsisの転帰およびサイトカイン産生能におよぼす影響2012

    • Author(s)
      木村友則,渡邉栄三,織田成人,寺谷綾子
    • Organizer
      第25回日本外科感染症学会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] IRGM polymorphismswere associated with mortality and IL-6 blood levels of severely septic patients2012

    • Author(s)
      Watanabe E, Kimura T, Teratani A, Sakamoto T, Ikeda T, Ikeda K, Kotani J, Kitamura N, Oda S
    • Organizer
      The 6th International Symposium on Autophagy 2012
    • Place of Presentation
      沖縄
    • Related Report
      2012 Final Research Report
  • [Presentation] Tumor necrosis factor -308 polymorphism is associated with mortality and ventilator free days in1057 Caucasian patients2012

    • Author(s)
      Watanabe E, Zehnbauer BA, Buchman TG, Hirasawa H, Oda S
    • Organizer
      The ShockSociety's 35th Annual Conference on Shock
    • Place of Presentation
      Miami U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] IRGM polymorphisms were associated with mortality and IL-6 blood levels of severely septic patients2012

    • Author(s)
      Eizo Watanabe, Tomonori Kimura, Ayako Teratani, Teruo Sakamoto, Toshiaki Ikeda, Kazumi Ikeda, Joji Kotani, Nobuya Kitamura, Shigeto Oda
    • Organizer
      The 6th International Symposium on Autophagy 2012
    • Place of Presentation
      Okinawa
    • Related Report
      2012 Annual Research Report
  • [Presentation] インターロイキン(IL-1)関連遺伝子多型のsepsisの転帰およびサイトカイン産生能におよぼす影響2012

    • Author(s)
      木村 友則,渡邉 栄三,織田 成人,寺谷 綾子
    • Organizer
      第25回日本外科感染症学会総会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 木村 友則,渡邉 栄三,織田 成人,貞広智仁,仲村将高,立石順久,篠崎広一郎,平澤 博之2012

    • Author(s)
      インターロイキン(IL)-1関連遺伝子多型のsepsisの転帰およびIL-6血中濃度におよぼす影響
    • Organizer
      第49回日本外科代謝栄養学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 重症患者における遺伝子多型の多施設共同前向き研究と新規敗血症関連遺伝子多型の検索2011

    • Author(s)
      渡邊栄三、織田成人、木村友則, 他
    • Organizer
      第39回日本救急医学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重症外傷例の転帰に影響を与える敗血症関連遺伝子多型-Critical Care Genomics-2011

    • Author(s)
      渡邊栄三、織田成人、木村友則, 他
    • Organizer
      第25回日本外傷学会
    • Place of Presentation
      堺市
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重症患者における遺伝子多型の多施設共同前向き研究と新規敗血症関連遺伝子多型の検索2011

    • Author(s)
      渡邉栄三,織田成人,木村友則,寺谷綾子,貞広智仁,仲村将高,安部隆三,中田孝明,島田忠長,大谷俊介
    • Organizer
      第39回日本救急医学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 重症患者における遺伝子多型の多施設共同前向き研究と新規敗血症関連遺伝子多型の検索2011

    • Author(s)
      渡邉栄三,織田成人,木村友則,寺谷綾子,貞広智仁,仲村将高,平山陽,立石順久,服部憲幸,瀬戸口大典,仲村志芳,高橋和香,高井信幸,今枝太郎,内山なつみ,島居傑,島田忠長,大谷俊介,北村伸哉,平澤博之
    • Organizer
      日本外科代謝栄養学会第48回学術集会
    • Place of Presentation
      愛知
    • Related Report
      2012 Final Research Report
  • [Presentation] 重症外傷症例の転帰に影響を与える敗血症関連遺伝子多型-Critical Care Genomics-2011

    • Author(s)
      渡邉栄三,織田成人,木村友則,佐藤泰憲,平澤博之,Timothy G. Buchman
    • Organizer
      第25回日本外傷学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 敗血症症例におけるautophagy関連遺伝子多型の炎症反応に対する影響2011

    • Author(s)
      木村友則,渡邉栄三,織田成人,貞広智仁,仲村将高,平山陽,立石順久,高橋和香,中田孝明,島田忠長
    • Organizer
      第38回日本集中治療医学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of heritable and acquired conditions on Mortality of 854 US patients with severe sepsis2010

    • Author(s)
      Watanabe E
    • Organizer
      33^<rd> Annual Conference on Shock
    • Place of Presentation
      Portland Oregon
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of heritable and acquired conditions on mortality of 854 US patients with severe sepsis2010

    • Author(s)
      Watanabe E, Zehnbauer BA, Oda S,Hirasawa H, Shimada T, Buchman TG
    • Organizer
      The Shock Society's 33rd Annual Conference on Shock
    • Place of Presentation
      Oregon, U.S.A.
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi