Tailor-made medicine based on genetic polymorphism analyses in relation to biological and immunological responses
| Project/Area Number |
22390335
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Chiba University |
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Principal Investigator |
ODA Shigeto 千葉大学, 大学院・医学研究院, 教授 (90204205)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 生体反応 / 遺伝子多型 / DNAアレイ / 表現型 / サイトカイン / 個別化治療 |
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| Research Abstract |
This study aims to establish the tailor-made medicine based on genetic polymorphism analysis in Japanese population. To determine the genetic effects on pathophysiology of severe sepsis, we investigated whether IL-1RA 2nd intron variable number of tandem repeat (VNTR) polymorphism bears influences on the susceptibility to and the outcome of severe sepsis. And, we also evaluated association between the VNTR and ex vivo expression of cytokines. Two hundred and sixty one patients who had admitted to an ICU (intensive care unit) were enrolled into a discovery cohort and 793 ICU patients admitted to the 5 different institutes were enrolled into a validation cohort. The IL1RA RN^*2, which was suggested to be a less IL-1ra producer, was associated with adverse outcome of severe sepsis via lower regulatory potential against some inflammatory cytokine production in Japanese population.
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Report
(4 results)
Research Products
(21 results)
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[Presentation] 重症患者における遺伝子多型の多施設共同前向き研究と新規敗血症関連遺伝子多型の検索2011
Author(s)
渡邉栄三,織田成人,木村友則,寺谷綾子,貞広智仁,仲村将高,平山陽,立石順久,服部憲幸,瀬戸口大典,仲村志芳,高橋和香,高井信幸,今枝太郎,内山なつみ,島居傑,島田忠長,大谷俊介,北村伸哉,平澤博之
Organizer
日本外科代謝栄養学会第48回学術集会
Place of Presentation
愛知
Related Report
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