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CXCL14/BRAK is a multifunctional tumor suppressor

Research Project

Project/Area Number 22390353
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKanagawa Dental College

Principal Investigator

HATA Ryu-ichiro  神奈川歯科大学, 歯学部, 特任教授 (10014276)

Co-Investigator(Kenkyū-buntansha) MAEHATA Youjirou  神奈川歯科大学, 歯学部, 講師 (80410009)
IZUKURI Kazuhito  神奈川歯科大学, 歯学部, 講師 (90257296)
KATO Yasumasa  奥羽大学, 歯学部, 教授 (50214408)
KURATA Shunichi  東京医科歯科大学, 難治疾患研究所, 准教授 (60140901)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywords癌抑制因子 / ケモカイン / 転移抑制 / 副作用のない癌抑制法 / 腫瘍抑制 / CXCL14/BRAK / BRAK / CXCL14 / ドーマントセラピー / 血管新生阻害 / NK細胞
Research Abstract

Objectives: The aim of this study was to determine whether or not chemokine BRAK/ CXCL14 transgenic (Tg) mice would show resistance to carcinogenesis, tumor growth and tumor metastasis. Methods: Wild type C57BL/6 (Wt) or Tg mice were injected intraperitoneally with 12 mg/kg body weight azoxymethane followed by intermittent addition of 3 % dextran sodium sulfate in the drinking water. We also injected tumor cells subcutaneously or via a tail vein of the mice. Results: No difference of body weight was observed between Wt and Tg mice but the rate of colorectal cancer was nearly ten times higher (P<0.001) in Wt mice than in Tg ones. Size of transplanted tumors and the number of metastatic foci on the lung of the animals were always significantly lower in the Tg that those in the Wt. Survival rates of the melanoma cell injected Tg mice were significantly higher than those of Wt. Conclusion: The Tg mice showed resistance to carcinogenesis, tumor growth and tumor cell metastasis, indicating BRAK/ CXCL14 has multifunctional effects on tumor suppression.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(84 results)

All 2013 2012 2011 2010

All Journal Article Presentation Book Patent(Industrial Property Rights)

  • [Journal Article] Chemokine CXCL14/BRAK is a multifunctional tumor suppressor for head and neck squamous cell carcinoma.2012

    • Author(s)
      Hata R: A new strategy to find targets for anticancer therapy
    • Journal Title

      ISRN Otolaryngology

      Volume: ID797619 Pages: 1-12

    • URL

      http://www.hindawi.com/isrn/otolaryngology/2012/797619/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK.2012

    • Author(s)
      Miyamoto C, Maehata Y, Ozawa S, Ikoma T, Kubota E, Izukuri K, Kato Y, Hata R, Lee M-C
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 120 Pages: 241-249

    • NAID

      10031147570

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium-calmodulin signaling induced by epithelial cell differentiation upregulates BRAK/CXCL14 expression via the binding of SP1 to the BRAK promoter region.2012

    • Author(s)
      Ikoma T., Ozawa S., Suzuki K., Kondo T., Maehata Y., Lee MC., Hata R., Kubota E.
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 420 Pages: 217-222

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2012.01.157

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new strategy to find targets for anticancer therapy: Chemokine CXCL14/BRAK is a multifunctional tumor suppressor for head and neck squamous cell carcinoma.2012

    • Author(s)
      Hata R.
    • Journal Title

      ISRN Otolaryngology

      Volume: 2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine CXCL14/BRAK stimulates differentiation of cancer stem cells2012

    • Author(s)
      Ryu-Ichiro Hata, Kaori Sato-Kusubata, Shigeyuki Ozawa, Yasumasa Kato, Miho Kusuda Furue
    • Journal Title

      Connective Tissue

      Volume: 53 Pages: 70-71

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MAPキナーゼのサブタイプ特異的シグナルクロストークによるがん抑制性ケモカインCXCL14/BRAKの発現制御.2011

    • Author(s)
      畑隆一郎
    • Journal Title

      生化学

      Volume: 83(8) Pages: 731-736

    • NAID

      10029575089

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of chemokine CXCL14 in rat hypothalamic neurons.2011

    • Author(s)
      Yamamoto T, Yamashita A, Yamada K,Hata R.
    • Journal Title

      Neurosci Lett.

      Volume: 487(3) Pages: 335-340

    • URL

      http://dx.doi.org/10.1016/j.neulet.2010.10.051

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MAPキナーゼのサブタイプ特異的シグナルクロストークによるがん抑制性ケモカインCXCL14/BRAKの発現制御2011

    • Author(s)
      畑隆一郎
    • Journal Title

      生化学

      Volume: 83 Pages: 731-736

    • NAID

      10029575089

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] InductionofdNp63bythe newly identified keratinocyte-specific transforming growth factor b signaling pathway with smad2 and IkB kinase α in squamous cell carcinoma.2010

    • Author(s)
      Fukunishi N, Katoh I, Tomomori Y, Tsukinoki K, Hata R, Nakano A, Ikawa Y,Kurata S
    • Journal Title

      Neoplasia

      Volume: 12(12) Pages: 969-979

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003132/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production of conditional knockout mice for chemokine BMAC/cxcl14 gene by Cre/loxP system.2010

    • Author(s)
      Yajima N, Izukuri K, Hata R
    • Journal Title

      Inflammation and Regeneration

      Volume: 30(6) Pages: 536-541

    • NAID

      130004482274

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reactive Oxygen Species (ROS) Reduce the Expression of BRAK/CXCL14 in Human Head and Neck Squamous Cell Carcinoma Cells.2010

    • Author(s)
      Maehata Y, Ozawa S, Kobayashi K, Kato Y, Yoshino F, Miyamoto C, Izukuri K, Kubota E, Hata R, Lee MC
    • Journal Title

      Free Radical Research

      Volume: 44(8) Pages: 913-924

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of serum BRAK/CXCL14 levels in healthy volunteers.2010

    • Author(s)
      Izukuri K, Ito S, Nozaki N, Yajima N, Iwamiya M, Kawahara S, Suzuki K, Kubota E, Hata R
    • Journal Title

      Laboratory Medicine

      Volume: 41(8) Pages: 478-482

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a chemokine BRAK/CXCL14 in oral floor carcinoma cells reduces the settlement rate of the cells and suppresses their proliferation in vivo.2010

    • Author(s)
      Ito S, Ozawa S, Ikoma T, Yajima N, Kiyono T, Hata R.
    • Journal Title

      Biomedical Research

      Volume: 31(3) Pages: 199-206

    • URL

      https://www.jstage.jst.go.jp/article/biomedres/31/3/31_3_199/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine CXCL14/BRAK transgenic mice suppress growth of carcinoma cell transplants.2010

    • Author(s)
      Izukuri K, Suzuki K, Yajima N, Ozawa S, Ito S, Kubota E, Hata R
    • Journal Title

      Transgenic Research

      Volume: 19(6) Pages: 1109-17

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Humanp38deltaMAPkinasemediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14.2010

    • Author(s)
      OzawaS,ItoS,KatoY,KubotaE,Hata R
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 396(4) Pages: 1060-1064

    • URL

      http://www.sciencedirect.com/science/article/pii/S0006291X10009630

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of proximal promoter of gene for human BRAK/CXCL14, a tumor-suppressing chemokine.2010

    • Author(s)
      Komori R., Ozawa S., Kato Y., Shinji H., Kimoto S, Hata R.
    • Journal Title

      Biomedical Research

      Volume: 31(2) Pages: 123-31

    • URL

      https://www.jstage.jst.go.jp/article/biomedres/31/2/31_2_123/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of tumor-suppressing chemokine BRAK/CXCL14 reduces cell migration rate of HSC-3 tongue carcinoma cells and stimulates attachment to collagen and formation of elongated focal adhesions in vitro.2010

    • Author(s)
      Sato K, Ozawa S, Izukuri K, Kato Y, Hata R
    • Journal Title

      Cell Biology International

      Volume: 348(5) Pages: 513-22

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of tumor-suppressing chemokine BRAK/CXCL14 reduces cell migration rate of HSC-3 tongue carcinoma cells and stimulates attachment to collagen and formation of elongated focal adhesions in vitro2010

    • Author(s)
      Sato K, Ozawa S, Izukuri K, Kato Y, Hata R
    • Journal Title

      Cell Biology International

      Volume: 348 Pages: 513-522

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of proximal promoter of gene for human BRAK/CXCL14, a tumor-suppressing chemokine2010

    • Author(s)
      Komori R., Ozawa S., Kato Y., Shinji H., Kimoto S, Hata RI.
    • Journal Title

      Biomedical Research

      Volume: 31 Pages: 123-131

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p38delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL142010

    • Author(s)
      Ozawa S, Ito S, Kato Y, Kubota E, Hata R
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 396 Pages: 1060-1064

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine CXCL14/BRAK transgenic mice suppress growth of carcinoma cell transplants2010

    • Author(s)
      Izukuri K, Suzuki K, Yajima N, Ozawa S, Ito S, Kubota E, Hata R
    • Journal Title

      Transgenic Research

      Volume: 19 Pages: 1109-1117

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a chemokine BRAK/CXCL14 in oral floor carcinoma cells reduces the settlement rate of the cells and suppresses their proliferation in vivo2010

    • Author(s)
      Ito S, Ozawa S, Ikoma T, Yajima N, Kiyono T, Hata R
    • Journal Title

      Biomedical Research

      Volume: 31 Pages: 199-206

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of serum BRAK/CXCL14 levels in healthy volunteers2010

    • Author(s)
      Izukuri K, Ito S, Nozaki N, Yajima N, Iwamiya M, Kawahara S, Suzuki K, Kubota E, Hata R
    • Journal Title

      Laboratory Medicine

      Volume: 41 Pages: 478-482

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive Oxygen Species (ROS) Reduce the Expression of BRAK/CXCL14 in Human Head and Neck Squamous Cell Carcinoma Cells2010

    • Author(s)
      Maehata Y, Ozawa S, Kobayashi K, Kato Y, Yoshino F, Miyamoto C, Izukuri K, Kubota E, Hata R, Lee MC
    • Journal Title

      Free Radical Research

      Volume: 44 Pages: 913-924

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of conditional knockout mice for chemokine BMAC/cxcl14 gene by Cre/loxP system2010

    • Author(s)
      Yajima N, Izukuri K, Hata R
    • Journal Title

      Inflammation and Regeneration

      Volume: 30 Pages: 536-541

    • NAID

      130004482274

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of dNp63 by the newly identified keratinocyte-specific transforming growth factor b signaling pathway with smad2 and IkB kinase a in squamous cell carcinoma2010

    • Author(s)
      Fukunishi N, Katoh I, Tomomori Y, Tsukinoki K, Hata R, Nakano A, Ikawa Y, Kurata S
    • Journal Title

      Neoplasia

      Volume: 12 Pages: 969-979

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of chemokine CXCL14 in rat hypothalamic neurons2010

    • Author(s)
      Yamamoto T, Yamashita A, Yamada K, Hata R
    • Journal Title

      Neuroscience Letter

      Volume: 487 Pages: 335-340

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of chemokine BRAK/CXCL14 suppresses tumor growth and metastasis NK cell dependently and increases survival rate of tumor-bearing mice.2013

    • Author(s)
      Hata R, Izukuri K, Kato Y, Takeda K,Kiyono T, Mukaida N, Taniguchi M
    • Organizer
      9th AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Maui, Hawaii, USA
    • Year and Date
      2013-02-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of chemokine BRAK/CXCL14 suppresses tumor growth and metastasis NK cell dependently and metastasis NK cell dependently and increases survival rate of tumor-bearing mice.2013

    • Author(s)
      Hata R,
    • Organizer
      9th AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Maui, Hawaii
    • Related Report
      2012 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌における ROCK 阻害剤 Fasudil による抗腫瘍ケモカイン CXCL14/BRAK への影 響の検討.2013

    • Author(s)
      宮本千央
    • Organizer
      神奈川歯科大学学会 第 140 回例会
    • Place of Presentation
      横須賀,神奈川
    • Related Report
      2012 Annual Research Report
  • [Presentation] Expression of chemokine CXCL14/BRAK suppresses tumor cell metastasis.2012

    • Author(s)
      Hata R, Izukuri K, Kato Y
    • Organizer
      90th International Association for Dental Research, Iguassu Falls
    • Place of Presentation
      Brazil
    • Year and Date
      2012-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] NK cells are indispensable for suppression of tumor growth and metastasis in transgenic mice over-expressing chemokine CXCL14/BRAK.2012

    • Author(s)
      Hata R, Izukuri K, Kato Y, Takeda K, Kiyono T, Mukaida N, Taniguchi M
    • Organizer
      American Association for Cancer Research Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2012-04-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Reactive oxygen species reduce the production of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells.2012

    • Author(s)
      Maehata Y, Ozawa S, Yoshino F, KobayashiK,MiyamotoC,KatoY.,Hata R, Lee M-C
    • Organizer
      The EMBO Meeting, Nice
    • Place of Presentation
      France
    • Related Report
      2012 Final Research Report
  • [Presentation] Lee M-C: ROCK Inhibitor Fasudil suppresses growth of fibrosarcoma by stimulating secretion of chemokine2012

    • Author(s)
      Miyamoto C., Maehata Y, Ozawa S.,Ikoma T., Hata R.
    • Organizer
      CXCL14/BRAK. The EMBO Meeting, Nice
    • Place of Presentation
      France.
    • Related Report
      2012 Final Research Report
  • [Presentation] A new strategy to find targets for anticancer therapy: Chemokine CXCL14/ BRAK is a multifunctional tumor suppressor2012

    • Author(s)
      Hata R
    • Organizer
      Bit’s 5th Annual World Cancer Congress(招待講演)
    • Place of Presentation
      Beijng, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NK cells are indispensable for suppression of tumor growth and metastasis in transgenic mice overexpressing chemokine CXCL14/BRAK.2012

    • Author(s)
      Hata R
    • Organizer
      American Association for Cancer Research Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Expression of chemokine CXCL14/BRAK suppresses tumor cell metastasis.2012

    • Author(s)
      Hata R,
    • Organizer
      90th International Association for Dental Research
    • Place of Presentation
      Iguassu Falls, Brazi
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reactive oxygen species reduce the production of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells.2012

    • Author(s)
      Maehata Y,
    • Organizer
      The EMBO Meeting
    • Place of Presentation
      Nice, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] Fasudil suppresses growth of fibrosarcoma by stimulating secretion of chemokine CXCL14/BRAK.2012

    • Author(s)
      Miyamoto C.
    • Organizer
      The EMBO Meeting
    • Place of Presentation
      Nice, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] ケモカインCXCL14/BRAKは癌細胞の肺転移を抑制する.2012

    • Author(s)
      畑隆一郎
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山, 福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] ROCK 阻害剤(fasudil)による抗腫瘍性ケモカイン(CXCL14/BRAK)の分泌促進作用を応用した新規抗 腫瘍療法の研究開発.2012

    • Author(s)
      宮本千央
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山, 福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌細胞において酸化ストレスは腫瘍抑制性ケモカインBRAK/CXCL14の発現を抑制 する.2012

    • Author(s)
      前畑洋次郎,
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山, 福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] p63 (TP63) activates Wnt target gene expression by directly interacting with TCF2012

    • Author(s)
      Katoh I,
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Annual Research Report
  • [Presentation] Expression of CXCL14/BRAK suppresses tumor growth and metastasis and prolongs the life span of tumor-burden mice.2012

    • Author(s)
      Hata R,
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Annual Research Report
  • [Presentation] NK cell-dependent suppression of tumor growth and metastasis in CXCL14/BRAK transgenic mice2011

    • Author(s)
      Ryu-Ichiro Hata, Yasumasa Kato, Kazuyoshi Takeda, Masaru Taniguchi
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ROCK阻害剤fasudi1によるCXCL14/BRACK分泌促進を介した抗腫〓効果の検討2011

    • Author(s)
      宮本千央, 前畑洋次郎, 小澤重幸, 生駒丈晴, 居作和人, 畑隆一郎, 李昌一
    • Organizer
      神奈川歯科大学学会第46回総会
    • Place of Presentation
      横須賀
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ケモカインCXCL14/BRAK遺伝子トランスジェニックマウスの腫瘍抑制・転移抑制機構の解明2011

    • Author(s)
      居作和人, 畑隆一郎
    • Organizer
      神奈川歯科大学学会第46回総会
    • Place of Presentation
      横須賀
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRPM-5は.酸性細胞外pHシグナルに関与し.メラノーマの肺転移に関与する2011

    • Author(s)
      加藤靖正.畑隆一郎.佃守.宮崎香.長嶋洋治
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 扁平上皮癌でのp63による核内GSK-3bシグナルを介したb-cateninの制御2011

    • Author(s)
      加藤伊陽子.福西菜穂子.畑隆一郎.井川洋二.倉田俊一
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] オステオネクチンノックアウトマウスの肺における遺伝子発現プロファイリング2011

    • Author(s)
      加藤靖正, 前畑洋次郎, 前田豊信, 畑隆一郎
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] ROCK阻害剤(Fasudi1)は抗腫瘍性ケモカイン(CXCL14/BRAK)の細胞外分泌促進を介して腫瘍進展を抑制する2011

    • Author(s)
      宮本千央, 前畑洋次郎, 小澤重幸, 生駒丈晴, 小森令賀, 居作和人, 加藤靖正, 畑隆一郎, 李昌一
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fasudil, a specific inhibitor of ROCK, stimulates secretion of CXCL14/BRAK and suppresses tumor growth in vivo2011

    • Author(s)
      Miyamoto C., Maehata Y., Ozawa S., Ikoma T., Komori R., Hata R.-I., Lee M-C.
    • Organizer
      The EMBO meeting
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] NK cell-dependent suppression of tumor growth and metastasis in CXCL14/BRAK transgenic mice2011

    • Author(s)
      Ryu-Ichiro Hata, Kazuhito Izukuri, Yasumasa Kato
    • Organizer
      Roche/Nature Medicine Symposium on Cancer Immunology and Immunotherapy
    • Place of Presentation
      New Jersey, USA
    • Year and Date
      2011-09-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌に強いマウスを作る-副作用のない癌の治療法を目指して-2011

    • Author(s)
      畑隆一郎.居作和人.加藤靖正.小澤重幸.鈴木健司.生駒丈晴.前畑洋次郎.宮本千央.椎木直人.矢島伸之.久保田英朗.李昌一.槻木恵一
    • Organizer
      バイオアカデミックフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ケモカインCXCL14/BRAKは幹細胞分化因子か?2011

    • Author(s)
      畑隆一郎.佐藤-楠畑かおり.小澤重幸.加藤靖正
    • Organizer
      第43回日本結合組織学会学術大会・第58回マトリックス研究会大会合同学術集会
    • Place of Presentation
      別府
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Production of transgenic mice resistant to cancer cell growth and metastasis -Toward Cancer Therapy using Endogenous Tumor Suppressing Chemokines-.2011

    • Author(s)
      Hata R, Izukuri K, Kato Y.
    • Organizer
      2nd International Conference on Cancer Immunotherapy and Immunomonitoring
    • Place of Presentation
      Budapest,Hungary
    • Year and Date
      2011-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Production of transgenic mice resistant to cancer cell growth and metastasis-Toward Cancer Therapy using Endogenous Tumor Suppressing Chemokines-. (Received The Outstanding Abstract and Selected Oral Presentation Award)2011

    • Author(s)
      Ryu-Ichiro Hata, Kazuhito Izukuri, Yasumasa Kato
    • Organizer
      2nd International Conference on Cancer Immunotherapy and Immunomonitoring
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2011-05-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fasudil, an inhibitor of ROCK, suppresses tumor growth in vivo2011

    • Author(s)
      Miyamoto C, Maehata Y, Komori R, Kobayashi K, Hata R, Lee M
    • Organizer
      89^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2011-03-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of promoter region of human BRAK/CXCL14 in SCC cells2011

    • Author(s)
      Komori R, Ozawa S, Kato Y, Maehata Y, Shinji H, Hata R, Kimoto S
    • Organizer
      89^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2011-03-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oxidative stress reduces expression of CXCL14/BRAK in human SCC cells2011

    • Author(s)
      Maehata Y, Ozawa S, Miyamoto C, Kobayashi K, Komori R, Hata R, Lee M
    • Organizer
      89^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transgenic mice are resistant to carcinoma growth and metastasis2011

    • Author(s)
      Hata R, Izukuri K, Kato Y
    • Organizer
      89^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] NK cell-dependent suppression of tumor growth and metastasis in CXCL14/BRAK transgenic mice.2011

    • Author(s)
      Hata R, Izukuri K, Kato Y.
    • Organizer
      Roche/Nature Medicine Symposium on Cancer Immunology and Immunotherapy
    • Place of Presentation
      Nutley New Jersey, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Fasudil, a specific inhibitor of ROCK, stimulates secretion of CXCL14/BRAK and suppresses tumor growth in vivo.2011

    • Author(s)
      Miyamoto C., Maehata Y., Ozawa S., Ikoma T., Komori R., Hata R. Lee M- C
    • Organizer
      The EMBO meeting
    • Place of Presentation
      Vienna, Austria.
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規抗腫瘍性ケモカインBRAK/CXCL14の発現および分泌制御機構の解明~酸化ストレスはBRAKの発現と細胞外分泌を抑制する~2010

    • Author(s)
      前畑洋次郎, 宮本千央, 小澤重幸, 吉野文彦, 小林杏, 高橋聡子, 高橋俊介, 畑隆一郎, 李昌一
    • Organizer
      第25回日本酸化ストレス学会関東支部会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 選択的ROCK阻害剤による抗腫瘍性ケモカインBRAK/CXCL14を介した腫瘍進展抑制の検討2010

    • Author(s)
      宮本千央, 前畑洋次郎, 小澤重幸, 生駒田丈晴, 居作和人, 小林杏, 高橋聡子, 高橋俊介, 吉野文彦, 杉山秀太, 吉田彩佳, 畑隆一郎, 李昌一
    • Organizer
      第45回神奈川歯科大学学会総会
    • Place of Presentation
      横須賀(最優秀演題賞受賞)
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] ROCK阻害剤Fasudilによる抗腫瘍性ケモカインBRAK/CXCL14の細胞外分泌促進と腫瘍進展抑制の検討2010

    • Author(s)
      宮本千央, 前畑洋次郎, 小澤重幸, 生駒丈晴, 小森令賀, 居作和人, 加藤靖正, 畑隆一郎, 李昌一
    • Organizer
      第123回日本薬理学会関東部会
    • Place of Presentation
      下野,栃木
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 選択的ROCK阻害剤による抗腫瘍性ケモカインBRAK/CXCL14の腫瘍進展抑制の検討2010

    • Author(s)
      宮本千央, 前畑洋次郎, 小澤重幸, 生駒丈晴, 居作和人, 畑隆一郎, 李昌一
    • Organizer
      133回神奈川歯科大学学会例会
    • Place of Presentation
      横須賀
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌進展抑制因子BRAK/CXCL14遺伝子の発現制御機構-MAPキナーゼシグナルのクロストークによる制御-2010

    • Author(s)
      畑隆一郎, 居作和人, 加藤靖正
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] BRAK/CXCL14遺伝子トランスジェニックマウスの腫瘍抑制・転移抑制機構の解明2010

    • Author(s)
      居作和人, 加藤靖正, 畑隆一郎
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ROCK阻害剤はBRAK/CXCL14の細胞外分泌を促進し抗腫瘍効果を発揮する2010

    • Author(s)
      宮本千央, 前畑洋次郎, 高橋聡子, 高橋俊介, 杉山秀太, 徳富文彬, 加藤靖正, 畑隆一郎, 李昌一
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemokine CXCL14/BRAK transgenic mice suppress growth and metastasis of carcinoma cells.2010

    • Author(s)
      Hata R, Izukuri K, Suzuki K, Kato Y, Yajima N, Ozawa S, Ito S, Kubota E
    • Organizer
      14th International Congress of Immunology.
    • Year and Date
      2010-08-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Chemokine CXCL14/BRAK transgenic mice suppress growth and metastasis of carcinoma cells2010

    • Author(s)
      Hata R, Izukuri K, Suzuki K, Kato Y, Yajima N, Ozawa S, Ito S, Kubota E
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] BRAKに魅せられて2010

    • Author(s)
      畑隆一郎
    • Organizer
      第42回結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2010-08-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemokine BRAK/CXCL14 is a multifunctional tumor suppressor.2010

    • Author(s)
      Hata R, Izukuri K, Suzuki K, Yajima N, Ozawa S, Ito S, Kubota E
    • Organizer
      88th General Session & Exhibition of the IADR- 5th General Session of the Pan European Region of the IADR
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Chemokine BRAX/CXCL14 is a multifunctional tumor suppressor2010

    • Author(s)
      Hata R, Izukuri K, Suzuki K, Yajima N, Ozawa S, Ito S, Kubota E
    • Organizer
      88^<th> General Session & Exhibition of the IADR・5^<th> General Session of the Pan European Region of the IADR
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gene expression signatures at acidic extracellular pH in metastatic melanoma cells.2010

    • Author(s)
      Kato Y, Ozawa S, Maehata Y, Maeda T, Kubota E, Tsukuda M, Miyazaki K, Hata R.
    • Organizer
      Joint MRS-AACR Conference: Metastasis and the Tumor Microenvironment.
    • Place of Presentation
      Philadelphia, PA.
    • Related Report
      2012 Final Research Report
  • [Presentation] NK cell-dependent suppression of tumor growth and metastasis in CXCL14/BRAK transgenic mice.2010

    • Author(s)
      Hata R, Izukuri K, Kato Y
    • Organizer
      Tumor Immunology: Basic and Clinical Advances
    • Place of Presentation
      Miami Beach, FL.
    • Related Report
      2012 Final Research Report
  • [Presentation] Gene expression signatures at acidic extracellular pH in metastatic melanoma cells2010

    • Author(s)
      Kato Y, Ozawa S, Maehata Y, Maeda T, Kubota E, Tsukuda M, Miyazaki K, Hata R
    • Organizer
      Joint MRS-AACR Conference : Metastasis and the Tumor Microenvironment
    • Place of Presentation
      Philadelphia, PA
    • Related Report
      2010 Annual Research Report
  • [Presentation] NK cell-dependent suppression of tumor growth and metastasis in CXCL14/BRAK transgenic mice2010

    • Author(s)
      Hata R, Izukuri K, Kato Y
    • Organizer
      Tumor Immunology : Basic and Clinical Advances
    • Place of Presentation
      Miami Beach, FL
    • Related Report
      2010 Annual Research Report
  • [Presentation] ROCK阻害剤FasudilはケモカインBRAK/CXCL14の細胞外分泌を促進し抗腫瘍効果を発揮する2010

    • Author(s)
      宮本千央, 前畑洋次郎, 小澤重幸, 加藤靖正, 畑隆一郎, 李昌一
    • Organizer
      第42回結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田(Young Investigator Award受賞)
    • Related Report
      2010 Annual Research Report
  • [Presentation] BRAK発現制御機構と口腔扁平上皮癌に対する抗腫瘍効果についての基礎的研究2010

    • Author(s)
      小澤重幸, 鈴木健司, 生駒丈晴, 近藤忠雄, 畑隆一郎, 久保田英朗
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張,千葉(ゴールドメダル受賞)
    • Related Report
      2010 Annual Research Report
  • [Presentation] CXCL14/BRAKの口腔扁平上皮癌に対する抗腫瘍効果について2010

    • Author(s)
      久保田英朗, 小澤重幸, 鈴木健司, 生駒丈晴, 近藤忠雄, 畑隆一郎
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張,千葉
    • Related Report
      2010 Annual Research Report
  • [Book] 口腔生化学第5版2011

    • Author(s)
      畑隆一郎.高橋信博.宇田川信之.東俊文.上條竜太郎.石崎明.加藤靖正[編著], 早川太郎.須田立雄.木崎治俊[監修]
    • Total Pages
      352
    • Publisher
      医師薬出版
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌転移抑制剤及び医薬組成物2010

    • Inventor(s)
      畑隆一郎
    • Industrial Property Rights Holder
      神奈川歯科大学
    • Patent Publication Number
      2012-012330
    • Filing Date
      2010-06-30
    • Related Report
      2012 Final Research Report

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Published: 2010-08-22   Modified: 2019-07-29  

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