Therapeutic strategy for oral cancer based on hypoxia PET imaging
| Project/Area Number |
22390377
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Yutaka 北海道大学, 北海道大学病院, 講師 (90250464)
TAMAKI Nagara 北海道大学, 大学院・医学研究科, 教授 (30171888)
INUBUSHI Masayuki 放射線医学総合研究所, 分子イメージング 研究センター, 研究員 (70399830)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 分子イメージング / 遺伝子イメージング / 低酸素 / PET / 頭頸部癌 / 化学療法 / 放射線治療 / 治療抵抗性 / 核医学(PET) / FMISO / 口腔癌 / 臨床研究 / 動物モデル / 核医学(PET,SPECT) / 臨床試験 |
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| Research Abstract |
Establishment of genetic hypoxia imaging is very critical for the treatment of oral cancer. The expression of the human sodium-iodide symporter (hNIS) gene is visualized by positron emission tomography (PET) and single photon emission computed tomography (SPECT). Our group has already established cell lines stably expressing hNIS. We established the cancer cell line stably expressing hNIS (HCT116-hNIS line B), and succeeded in imaging the mouse xenograft model by 99mTcO4SPECT. In the future, this model will provide a tool to track tumor metastasis in vivo in mice so that the molecular mechanism involved in metastatic cascade will be elucidated.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] A case of oncocytic carcinoma arising from the submandibular gland with bilateral multiple cervical lymph node metastases2013
Author(s)
Kyan-Onodera M, Satoh C, Yamazaki Y, Satoh A, Sugiura C, Notani K, Iizuka T, Shindoh M, Kitagawa Y
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 25
Pages: 97-100
Related Report
Peer Reviewed
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