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Personalized immunochemotherapy for oral cancer basedon the genetic diagnosis

Research Project

Project/Area Number 22390386
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionEhime University

Principal Investigator

HAMAKAWA Hiroyuki  愛媛大学, 大学院・医学系研究科, 教授 (20127905)

Co-Investigator(Kenkyū-buntansha) NAKASHIRO Koichi  愛媛大学, 大学院・医学系研究科, 准教授 (90314880)
Co-Investigator(Renkei-kenkyūsha) OKAMOTO Masato  慶應大学, 医学部, 特任准教授 (10243718)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywords口腔癌 / 癌免疫療法 / 癌抗原 / OK-432 / 免疫療法 / 樹状細胞 / WT1
Research Abstract

Recently immunotherapy is a promising cancer therapy. And Dendritic cells (DC)-based vaccination is widely tested as a promising therapeutic cancer vaccine in multiple clinical trials. But there is no utility cancer antigen for oral cancer. We have identified Mucin 1 as a critical cancer antigen in oral cancer. Furthermore we conducted the in vitro experiments to examine whether or not chemotherapeutic drugs which are used for patients with oral cancer, may enhance T cell-stimulating ability of DCsvia regulation of the expression of PD-Ls. And then we identified IL-6, IL-8 and GCSFas a prognosis biomarker of oral cancer patients. The findings obtained from this study lead to development of personalized immunochemotherapy for oral cancer patients.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(52 results)

All 2013 2012 2011 2010

All Journal Article Presentation Patent(Industrial Property Rights)

  • [Journal Article] Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells2013

    • Author(s)
      Sumida T, Murase R, Onishi-Ishikawa A, McAllister SD, Hamakawa H, Desprez PY
    • Journal Title

      BMC Cancer

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting Aurora kinase A suppresses the growth of human oral squamous cell carcinoma cells in vitro and in vivo.2013

    • Author(s)
      Tanaka H, Nakashiro K, Iwamoto K, Tokuzen N, Fujita Y, Shirakawa R, Oka R,Goda H, Hamakawa H
    • Journal Title

      Oral Oncol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined TLR2/4-Activated Dendritic/Tumor Cell Fusions Induce Augmented Cytotoxic T Lymphocytes.2013

    • Author(s)
      Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, Odahara S, Tsukinaga S, Yukawa T, Mitobe J, Matsudaira H, Nagatsuma K, Uchiyama K, Kajihara M, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H
    • Journal Title

      PLoS One

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT). Impact of dendritic cell vaccines pulsed with Wilms' tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers.2013

    • Author(s)
      Takahashi H, Okamoto M, Shimodaira S, Tsujitani S, Nagaya M, Ishidao T, Kishimoto J, Yonemitsu Y
    • Journal Title

      Eur J Cancer

      Volume: 49(4) Pages: 852-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of expression of bcl-2 and bax genes in circulating immune cells derived from patients with head and neck carcinoma2013

    • Author(s)
      Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, Homma S, Sato M,Fujita T, Kawakami Y, Hamakawa H.
    • Journal Title

      Neoplasia

      Volume: 15(3) Pages: 305-14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epulis-like gingival angiosarcoma of the mandible: a case report.2012

    • Author(s)
      Sumida T, Murase R, Fujita Y, Ishikawa A, Hamakawa H.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 5(8) Pages: 830-3

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro2012

    • Author(s)
      Kan S, Hazama S, Maeda K, Inoue Y, Homma S, Koido S, Okamoto M, Oka M
    • Journal Title

      Anticancer Res

      Volume: 32(12) Pages: 5363-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective inhibition of NF-κB suppresses bone invasion by oral squamous cell carcinoma in vivo2012

    • Author(s)
      Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Khan M, Aoki K, Ohya K, Okamoto M, Tominaga K, Takahashi T, Nakanishi O, Jimi E.
    • Journal Title

      Int J Cancer

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinoma2012

    • Author(s)
      Goda H, Nakashiro K, Oka R, Tanaka H, Wakisaka H, Hato N, Hyodo M, Hamakawa H.
    • Journal Title

      Oral Oncol

      Volume: 48(10) Pages: 958-63

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes.2012

    • Author(s)
      Mayorca-Guiliani AE, Yano H, Nakashiro K, Hamakawa H, Tanaka J
    • Journal Title

      Oral Oncol

      Volume: 48(8) Pages: 663-70

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition and apoptosis by an active component of OK-432, a streptococcal agent, via Toll-like receptor 4 in human head and neck cancer cell lines2012

    • Author(s)
      Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Yamashita N, Kawakami Y, Hamakawa H.
    • Journal Title

      Oral Oncol

      Volume: 48(8) Pages: 678-85

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma.2012

    • Author(s)
      Kimura Y, Tsukada J, Tomoda T, Takahashi H, Imai K, Shimamura K, Sunamura M, Yonemitsu Y, Shimodaira S, Koido S, Homma S, Okamoto M
    • Journal Title

      Pancreas

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinoma.2012

    • Author(s)
      Goda H
    • Journal Title

      Oral Oncology

      Volume: 48 Pages: 958-63

    • DOI

      10.1016/j.oraloncology.2012.03.026

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes.2012

    • Author(s)
      Mayorca-Guiliani AE
    • Journal Title

      Oral Oncology

      Volume: 48 Pages: 663670-663670

    • DOI

      10.1016/j.oraloncology.2012.02.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition and apoptosis by an active component of OK-432, a streptococcal agent, via Toll-like receptor 4 in human head and neck cancer cell lines.2012

    • Author(s)
      Tano T
    • Journal Title

      Oral Oncol

      Volume: 48 Pages: 678-685

    • DOI

      10.1016/j.oraloncology.2012.02.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Premetastic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes2012

    • Author(s)
      Mayorca-Guilliani AE, Yano H, Nakashiro K, Hamakawa H, Tanaka J
    • Journal Title

      Oral Oncology

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition and apoptosis by an active component of OK-432, a streptococcal agent, via Toll-like receptor 4 in human head and neck cancer cell lines2012

    • Author(s)
      Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Yamashita N, Kawakami Y, Hamakawa H
    • Journal Title

      Oral Oncology

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells.2011

    • Author(s)
      Shin M, Matsuo K, Tada T, Fukushima H, Furuta H, Ozeki S, Kadowaki T, Yamamoto K, Okamoto M, Jimi E
    • Journal Title

      Carcinogenesis

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased telomerase activity and hTERT expression in human salivary gland carcinomas2011

    • Author(s)
      Shigeishi H, Sugiyama M, Tahara H, Ono S, Kumar Bhawal U, Okura M, Kogo M, Shinohara M, Shindoh M, Shintani S, Hamakawa H, Takata T, Kamata N.
    • Journal Title

      Oncol Lett 1

      Volume: 2(5) Pages: 845-850

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Oral Cancer Study Group of Chugoku-Shikoku. Effects of a concurrent chemoradiotherapy with S-1 for locally advanced oral cancer2011

    • Author(s)
      Hino S, Hamakawa H, Miyamoto Y, Ryoke K, Sekine J, Sasaki A, Yamamoto T
    • Journal Title

      Oncol Lett 1

      Volume: 2(5) Pages: 839-843

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel Therapeutic Strategies for Malignant Salivary Gland Tumors : Lessons Learned from Breast Cancer (Review)2011

    • Author(s)
      Murase R, Sumida T, Ishikawa A, Murase R, McAllister SD, Hamakawa H, Desprez PY
    • Journal Title

      International Journal of Otolaryngology

    • DOI

      10.1155/2011/187623

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin.2011

    • Author(s)
      Nishikawa Y, Miyazaki T, Nakashiro K, Yamagata H, Isokane M, Goda H, Tanaka H, Oka R, Hamakawa H.
    • Journal Title

      Oncol Rep

      Volume: 26(3) Pages: 587-92

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells2011

    • Author(s)
      Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H
    • Journal Title

      Oncol Rep

      Volume: 25(3) Pages: 795-802

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Silencing Id-1 inhibits lymphangiogenesis through down-regulation of VEGF-C in oral squamous cell carcinoma.2011

    • Author(s)
      Dong Z, Wei F, Zhou C, Sumida T, Hamakawa H, Hu Y, Liu S
    • Journal Title

      Oral Oncol

      Volume: 47(1) Pages: 27-32

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Silencing Id-1 with RNA interference inhibits adenoid cystic carcinoma in mice2011

    • Author(s)
      Chen Z, Liu S, Sumida T, Sun S, Wei Y, Liu M, Dong Z, Zhang F, Hamakawa H, Wei F.
    • Journal Title

      J Surg Res

      Volume: 169(1) Pages: 57-66

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic strategies for malignant salivary gland tumors : lesson learned from breast cancer2011

    • Author(s)
      Murase R, Sumida T, Ishikawa A, Murase R, McAllister SD, Hamakawa H, Desprez PY
    • Journal Title

      International Journal of Otolaryngology

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin.2011

    • Author(s)
      Nishikawa, Y.
    • Journal Title

      Oncology Report

      Volume: 26(3) Pages: 587-592

    • DOI

      10.3892/or.2011.1324

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy for head and neck squamous carcinoma cells by IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells2011

    • Author(s)
      Zhang T, et al
    • Journal Title

      Oncol Rep

      Volume: 25 Pages: 795-802

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silencing Id-1 inhibits lymphangiogenesis through down-regulation of VEGF-C in oral squamous cell carcinoma2011

    • Author(s)
      Dong Z, et al
    • Journal Title

      Oral Oncol

      Volume: 47 Pages: 27-32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo.2010

    • Author(s)
      Sasaki T, Nakashiro K, Tanaka H, Azuma K, Goda H, Hara S, Onodera J, Fujimoto I, Tanji N, Yokoyama M, Hamakawa H
    • Journal Title

      Biochem Biophys Res Commun 13

      Volume: 399(1) Pages: 79-83

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carrier cell-mediated cell lysis of squamous cell carcinoma cells by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus2010

    • Author(s)
      Hamada K, Zhang T, Desaki J, Nakashiro K, Itoh H, Tani K, Koyama Y, Hamakawa H
    • Journal Title

      J Gene Med

      Volume: 12(6) Pages: 545-54

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Massive subcutaneous emphysema developing before surgery for mandibular fracture: a case report2010

    • Author(s)
      Sumida T, Kobayashi A, Oka R, Yorozuya T, Nagaro T, Hamakawa H
    • Journal Title

      Dent Traumatol

      Volume: 26(4) Pages: 363-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carrier cell-mediated cell lysis of squamous cell carcinoma cells by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus2010

    • Author(s)
      Hamada K, et al
    • Journal Title

      J Gene Med

      Volume: 12 Pages: 545-554

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔扁平上皮癌における癌抗原 WT1 および MUC1 の発現2013

    • Author(s)
      藤田陽平、中城公一、合田啓之、田野智之、浜川裕之
    • Organizer
      第31回日本口腔腫瘍学会総会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 5-FU による樹状細胞の SOCS 発現の抑制と T 細胞活性化能の増強2012

    • Author(s)
      田野智之、岡本正人、合田啓之、藤田陽平、中城公一、浜川裕之
    • Organizer
      第60回日本口腔科学会中四国地方部会
    • Place of Presentation
      広島
    • Year and Date
      2012-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 本院における化学療法を併用したペプチドパルス樹状細胞がんワクチン療法の臨床試験2012

    • Author(s)
      岡本正人、藤田知信、河上 裕
    • Organizer
      第22回日本樹状細胞研究会
    • Place of Presentation
      福島
    • Year and Date
      2012-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 化学療法を併用した樹状細胞がんワクチン療法の臨床試験への取り組み2012

    • Author(s)
      岡本正人、藤田知信、竹内裕也、船越 健、真柳修平、高石官均、田口淳一、砂村真琴、日比紀文、天谷雅行、北川雄光、河上 裕
    • Organizer
      第25回日本バイオセラピィ学会学術集会
    • Place of Presentation
      倉敷
    • Related Report
      2012 Final Research Report
  • [Presentation] 化学療法剤による樹状細胞の SOCS-1, -2 発現の抑制と T 細胞活性化能の増強2012

    • Author(s)
      田野智之、岡本正人、合田啓之、藤田陽平、中城公一、浜川裕之
    • Organizer
      第25回日本バイオセラピィ学会学術集会
    • Place of Presentation
      倉敷
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌SNNSの検証と新戦略2011

    • Author(s)
      浜川裕之
    • Organizer
      第13回SNNS研究会学術集会
    • Place of Presentation
      浜離宮朝日ホール・東京
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 樹状細胞がんワクチンの現状2011

    • Author(s)
      岡本正人
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 成熟樹状細胞の貪食能ならびに樹状細胞局所投与療法への応用に関する検討2011

    • Author(s)
      岡本正人、塚田 旬 、カンシン、木村 幸乃
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 治療経験のある進行膵癌に対する樹状細胞ワクチン療法~臨床的・免疫学的検討~2011

    • Author(s)
      岡本正人、木村幸乃、今井一弘、嶋村香苗、塚田 旬、石田尾武文、高橋秀徳、砂村真琴、下平繁隆、小井戸繁雄、本間 定
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] Immuno-chemoradiotherapy for head and neck cancer: Augmentation of OK-432- induced anti-tumor immunity by tegafur and radiation.2011

    • Author(s)
      Okamoto M, Tano T, Kan S, Sato M.
    • Organizer
      102ndAmerican Association for Cancer Research Annual Meeting
    • Place of Presentation
      Orlando, FL
    • Related Report
      2012 Final Research Report
  • [Presentation] 樹状細胞を用いた癌ワクチン療法~基礎から臨床へ~2011

    • Author(s)
      岡本正人
    • Organizer
      第29回日本口腔腫瘍学会総会
    • Place of Presentation
      熊本
    • Related Report
      2012 Final Research Report
  • [Presentation] One-step nucleic acid amplification (OSNA) method for detecting metastasis of oral cancer2010

    • Author(s)
      浜川裕之
    • Organizer
      The 7^<th> International Sentinel Node Meeting
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] アンドロゲン受容体遺伝子に特異的な siRNA2012

    • Inventor(s)
      中城公一、浜川裕之
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Acquisition Date
      2012-04-06
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 頭頸部癌の腫瘍マーカー2012

    • Inventor(s)
      中城公一、浜川裕之
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Acquisition Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ADAT1 遺伝子に特異的な siRNA2012

    • Inventor(s)
      中城公一、浜川裕之
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Acquisition Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] マイクロ RNA 又はその発現系を含む組成物2011

    • Inventor(s)
      中城公一、浜川裕之、田中宏史
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Industrial Property Number
      2011-113348
    • Filing Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] マイクロRNA又はその発現系を含む組成物2011

    • Inventor(s)
      中城公一、浜川裕之、田中宏史
    • Industrial Property Rights Holder
      愛媛大学
    • Industrial Property Number
      2011-113348
    • Filing Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロRNAのアンチセンスオリゴヌクレオチドを含む組成物2010

    • Inventor(s)
      中城公一、浜川裕之、田中宏史
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Industrial Property Number
      2010-254021
    • Filing Date
      2010-11-12
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] マイクロRNAのアンチセンスオリゴヌクレオチドを含む組成物2010

    • Inventor(s)
      中城公一, 浜川裕之, 田中宏史
    • Industrial Property Rights Holder
      愛媛大学
    • Industrial Property Number
      2010-254021
    • Filing Date
      2010-11-12
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-22   Modified: 2019-07-29  

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