A cohort study on the relationship between oral and systemic health conditions of island inhabitants
| Project/Area Number |
22390402
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAITO Toshiyuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (10170515)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHIDA Hideaki 長崎大学, 病院(歯学系), 講師 (20238140)
KAWASAKI Koji 長崎大学, 病院(医学系), 准教授 (60161303)
MAEDA Takahiro 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40284674)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 歯周病 / 歯周疾患 / 動脈硬化 / 疫学 / 頸動脈超音波検査 / 血清抗体価 / 酸化ストレス / 慢性炎症 / 頸動脈内膜中膜複合体厚(IMT) / アディポカイン |
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| Outline of Final Research Achievements |
Recent studies suggested an association between periodontitis and atherosclerosis; however, the relationship between periodontal status and arterial alterations was not clarified. We examined associations between periodontal status and carotid intimaemedia thickness (cIMT) and arterial stiffness using the cardio-ankle vascular index (CAVI) in a total of 1053 community dwellers (>=40 years with 10 teeth or more).
As results, in multi-variate analyses adjusted for age, sex, number of present teeth, and other confounders, both deep pocket and severe attachment loss were related to cIMT and also CAVI, significantly.
A linear, dose-dependent relationship was found between periodontal pocket depth, cIMT, and arterial stiffness.
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Report
(5 results)
Research Products
(14 results)
